Gastroesophageal Junction Adenocarcinoma

• CLINICAL_TRIALS research · 2025-09-10
  Clinical Trial Update: The Efficacy and Safety of Iparomlimab/Tuvonralimab (Anti PD-1/CTLA-4) Combined With Albumin-bound Paclitaxel in Second-line Treatment of Patients With Advanced Gastric/Gastroesophageal Junction Adenocarcinoma [NA]

  Clinical trial update for a second-line combination of Iparomlimab and Tuvonralimab with albumin-bound paclitaxel in advanced gastric or gas…

• CLINICAL_TRIALS trial_result · 2025-09-09
  Clinical Trial Update: Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers [Phase 2]

  Phase 2 trial evaluating tucatinib plus trastuzumab with oxaliplatin-based chemotherapy or pembrolizumab-containing regimens for HER2-positi…

• CLINICAL_TRIALS research · 2025-09-08
  Clinical Trial Update: Safety and Efficacy of Glumetinib Combined With Docetaxel for Injection (Albumin-bound) in Patients With Advanced Gastric Cancer/Gastroesophageal Junction Adenocarcinoma and Other Solid Tumors [Phase 2]

  Phase 2 clinical trial evaluating Glumetinib in combination with Nab-docetaxel for advanced gastric/gastroesophageal junction cancers and ot…

• CLINICAL_TRIALS trial_result · 2025-09-05
  Clinical Trial Update: Durvalumab, an Anti-PDLI Antibody, and Tremelimumab, an Anti-CTLA4 Antibody, and Chemoradiation Before Surgery for Esophageal Cancer [Phase 1, Phase 2]

  A phase 1/2 trial is evaluating durvalumab and tremelimumab with chemoradiation before surgery for esophageal and gastroesophageal junction …

• CLINICAL_TRIALS trial_result · 2025-08-29
  Clinical Trial Update: Comparing the Efficacy and Safety of Chemotherapy Combined With or Without Immunotherapy as Postoperative Adjuvant Regimens in Patients With Resectable Gastric Cancer/Adenocarcinoma of the Esophagogastric Junction After Radical Surgery [Phase 4]

  A Phase 4 trial update describing a study that compares postoperative adjuvant regimens of chemotherapy with or without immunotherapy in pat…

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• CLINICAL_TRIALS research · 2025-08-28
  Clinical Trial Update: MAIC of Fruquintinib Plus Paclitaxel Versus Ramucirumab Plus Paclitaxel in Advanced G/GEJ Adenocarcinoma

  Clinical trial update describing a matching-adjusted indirect comparison (MAIC) of Fruquintinib plus paclitaxel versus ramucirumab plus pacl…

• CLINICAL_TRIALS research · 2025-08-26
  Clinical Trial Update: An Open Label Phase 2 Study of Total Neoadjuvant Therapy (TNT) Consisting of FLOT With Pembrolizumab and Short Radiation for Patients With Locally Advanced Gastroesophageal Junction Adenocarcinoma [Phase 2]

  An open-label Phase 2 trial evaluating total neoadjuvant therapy with FLOT chemotherapy plus pembrolizumab and short radiation for locally a…

• CLINICAL_TRIALS research · 2025-08-24
  Clinical Trial Update: A Multicenter, Phase 3 Study of IBI343 Monotherapy Versus Treatment of Investigator's Choice in Subjects With Previously Treated, Claudin (CLDN) 18.2-positive, HER2-negative, Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 3]

  Phase 3 multicenter trial evaluating IBI343 monotherapy versus investigator's choice in previously treated CLDN18.2-positive, HER2-negative …

• CLINICAL_TRIALS research · 2025-08-17
  Clinical Trial Update: Assessing Iparomlimab and Tuvonralimab in Recurrent or Metastatic MSI-H/dMMR Gastric Cancer [Phase 2]

  Phase 2 clinical trial update for iparomlimab and tuvonralimab in MSI-H gastric/gastroesophageal junction adenocarcinoma; the study is curre…

• CLINICAL_TRIALS research · 2025-08-14
  Clinical Trial Update: Pan-tumor MRD Study

  Paradigm Health's Pan-tumor MRD study (NCT06605404) is currently recruiting across several solid tumor indications including bladder, esopha…

• CLINICAL_TRIALS research · 2025-08-07
  Clinical Trial Update: A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06) [Phase 2, Phase 3]

  Clinical trial update on evorpacept (ALX148) for advanced HER2-positive gastric cancer (ASPEN-06) noting that Phase 2 and Phase 3 cohorts ar…

• CLINICAL_TRIALS research · 2025-08-03
  Clinical Trial Update: A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer [Phase 2]

  Phase 2 clinical trial evaluating TRK-950 in combination with ramucirumab and paclitaxel for gastric cancer in recruiting status.

• CLINICAL_TRIALS trial_result · 2025-07-31
  Clinical Trial Update: Neoadjuvant Study Using Trastuzumab or Trastuzumab With Pertuzumab in Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 2]

  A Phase 2 neoadjuvant trial evaluating trastuzumab, with or without pertuzumab, in patients with gastric or gastroesophageal junction adenoc…

• CLINICAL_TRIALS research · 2025-07-31
  Clinical Trial Update: Novel SEQUEnced Immunotherapy With Anti-angiogenesis and Chemotherapy in Advanced gastroesophageaL Adenocarcinoma [Phase 2]

  A Phase 2 clinical trial update for sequential immunotherapy combining anti-angiogenesis and chemotherapy in advanced gastroesophageal junct…

• CLINICAL_TRIALS withdrawal · 2025-07-30
  Clinical Trial Update: A Clinical Trial of the Safety and Anti-Tumor Activity of AB-201 in Subjects With Advanced HER2+ Solid Tumors [Phase 1, Phase 2]

  The Phase 1/2 trial of AB-201 for HER2-positive solid tumors has been withdrawn, with the study status updated to withdrawn.

• CLINICAL_TRIALS research · 2025-07-25
  Clinical Trial Update: Study of Atezolizumab + FLOT vs. FLOT Alone in Patients With GC/GEJ and High Immune Responsiveness [Phase 2]

  Phase 2 study evaluating atezolizumab added to the FLOT chemotherapy regimen versus FLOT alone in patients with gastric cancer or gastroesop…

• CLINICAL_TRIALS research · 2025-07-22
  Clinical Trial Update: A Study of Minimally Invasive Proximal Gastrectomy Versus Minimally Invasive Total Gastrectomy for Gastric and Gastroesophageal Junction Cancers

  A clinical trial comparing minimally invasive proximal gastrectomy versus minimally invasive total gastrectomy for gastric and gastroesophag…

• CLINICAL_TRIALS research · 2025-07-20
  Clinical Trial Update: Tislelizumab Plus FOLFOX Versus POF in the Treatment of Locally Advanced: a Multicenter, Open-label, Randomized Phase III Studyunresectable or Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma [Phase 3]

  A multicenter, open-label Phase III study randomizes tislelizumab plus FOLFOX versus POF in locally advanced or metastatic gastric and gastr…

• CLINICAL_TRIALS research · 2025-07-17
  Clinical Trial Update: Fruquintinib in Combination With Sintilimab and CAPEOX as First-line Treatment for G/GEJ Cancer [Phase 1, Phase 2]

  A Phase 1/2 clinical trial is evaluating a triplet of Fruquintinib, Sintilimab, and the CAPEOX chemotherapy regimen as first-line therapy fo…

• CLINICAL_TRIALS research · 2025-07-11
  Clinical Trial Update: Pembrolizumab and Trifluridine/Tipiracil With Previously Treated Advanced Gastric Cancer [Phase 1, Phase 2]

  This clinical trial evaluates the combination of pembrolizumab with trifluridine/tipiracil in patients with previously treated advanced gast…

• CLINICAL_TRIALS research · 2025-07-10
  Clinical Trial Update: Neoadjuvant Cadonilimab Combined With Perioperative Oxaliplatin Plus S1 for Diffuse or Mixed Type of Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma [Phase 3]

  Phase 3 trial evaluating neoadjuvant cadonilimab plus perioperative oxaliplatin and S-1 for diffuse or mixed-type locally advanced gastric/G…

• CLINICAL_TRIALS trial_result · 2025-07-08
  Clinical Trial Update: Berzosertib and Irinotecan in Treating Patients With Progressive, Metastatic, or Unresectable TP53 Mutant Gastric or Gastroesophageal Junction Cancer [Phase 2]

  Phase 2 trial evaluating the combination of berzosertib with irinotecan for TP53-mutant advanced gastric or gastroesophageal junction cancer…

• CLINICAL_TRIALS research · 2025-07-08
  Clinical Trial Update: Real-world Effectiveness and Safety of Trastuzumab Deruxtecan in Patients With Locally Advanced or Metastatic HER2-positive Gastric or Gastroesophageal Junction Adenocarcinoma in China

  This clinical trial update describes a real-world evaluation of trastuzumab deruxtecan in Chinese patients with HER2-positive gastric or gas…

• CLINICAL_TRIALS research · 2025-06-27
  Clinical Trial Update: APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors [Phase 2]

  Phase 2 study evaluating APL-101 in non-small cell lung cancer with MET exon 14 skipping mutations and MET dysregulation, as well as other M…

• CLINICAL_TRIALS research · 2025-06-18
  Clinical Trial Update: Perioperative Treatment of Combined Radiotherapy With SOX, Apatinib and Camrelizumab for Oesophagogastric Cancer [Phase 2]

  Phase 2 trial evaluating perioperative radiotherapy combined with SOX (S-1 and oxaliplatin), apatinib, and camrelizumab for gastric and gast…