Gastroesophageal Junction Adenocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: SHR-1701 + Rivoceranib (± SHR-2554) in Advanced GC After First-Line Immunotherapy Failure [Phase 2]
Phase 2 clinical trial evaluating SHR-1701 in combination with rivoceranib (± SHR-2554) for advanced gastric cancer and gastroesophageal jun…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer [Phase 2]
Phase II trial (RAINSPOT) evaluating zolbetuximab combined with paclitaxel and ramucirumab in CLDN18.2-positive gastric and gastroesophageal…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Iparomlimab and Tuvonralimab Combined With Apatinib and Irinotecan Hydrochloride for the Treatment of Advanced Alpha-fetoprotein-producing Gastric Cancer (AFPGC) [Phase 2]
Phase 2 trial investigating a quadruple combination of Iparomlimab, Tuvonralimab, Apatinib, and Irinotecan hydrochloride for advanced Alpha-…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Propranolol in Combination With Pembrolizumab and Standard Chemotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Adenocarcinoma [Phase 2]
Phase 2 clinical trial evaluating propranolol in combination with pembrolizumab and standard chemotherapy for unresectable or metastatic eso…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer) [Phase 1, Phase 2]
A Roche-sponsored Phase 1/2 clinical trial evaluating multiple immunotherapy-based treatment combinations in patients with locally advanced …
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Zanidatamab Combined With Chemotherapy as Neoadjuvant Therapy for HER2-high Expression G/GEJC [Phase 2]
A Phase 2 neoadjuvant trial is evaluating Zanidatamab in combination with chemotherapy for HER2-high gastric/gastroesophageal junction adeno…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Feasibility of Circulating Tumor DNA Based Minimal Residual Disease-Guided Adjuvant Therapy in Locally Advanced Gastric Cancer With Neoadjuvant Treatment: An Adaptive Trial (MRD-ATLAS) [Phase 2]
This Phase 2 study (MRD-ATLAS) is evaluating whether circulating tumor DNA–based minimal residual disease guidance can inform adjuvant thera…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Hypofractionated Radiotherapy Combined With Immunochemotherapy for Conversion Treatment of Gastroesophageal Junction Adenocarcinoma [Phase 1, Phase 2]
An ongoing phase 1/2 trial evaluating hypofractionated radiotherapy combined with immunochemotherapy as conversion therapy for gastroesophag…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Phase II Basket Trial: Zanidatamab Plus Tislelizumab in HER2-Positive GI Tumors (UNION-HER2-BASKET) [Phase 2]
A Phase II basket trial is evaluating Zanidatamab in combination with Tislelizumab for HER2-positive gastrointestinal tumors, including rect…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: A Study of AK109 and AK104 in Advanced Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma [Phase 1, Phase 2]
This clinical trial update reports ongoing Phase 1/2 studies evaluating AK109 and AK104 in advanced gastric cancer and gastroesophageal junc…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: A Phase II Clinical Study Evaluating SSGJ-706 in Combination Therapy for Advanced Gastrointestinal Cancers [Phase 2]
Phase II clinical study evaluating SSGJ-706 in combination therapy for advanced gastrointestinal cancers is not yet recruiting. The study in…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Phase II, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of HLX43 (an Anti-PD-L1 ADC) in Subjects With Advanced Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 2]
Phase II open-label study evaluating HLX43, an anti-PD-L1 ADC, for advanced gastric or gastroesophageal junction adenocarcinoma; recruitment…
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: A Study of BL-M07D1 Versus Investigator's Choice of Chemotherapy in Patients With HER2-positive Locally Advanced or Metastatic Gastric or Gastro-esophageal Junction Adenocarcinoma [Phase 3]
This is a Phase 3 clinical trial comparing BL-M07D1 to investigator's choice chemotherapy in HER2-positive locally advanced or metastatic ga…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Folfox+Irinotecan+Chemort In Esophageal Cancer [Phase 2]
Phase 2 clinical trial evaluating a FOLFOX plus Irinotecan regimen with chemotherapy for gastroesophageal junction adenocarcinoma and esopha…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: Tadalafil Effect + Chemotherapy in Resectable Gastric/GEJ Cancer [Phase 2]
Phase 2 trial evaluating tadalafil in combination with chemotherapy for resectable gastric or gastroesophageal junction adenocarcinoma; curr…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: To Evaluate the Efficacy of CT041 in Sequential Treatment After First-line Treatment of Advanced Gastric/Esophagogastric Junction Adenocarcinoma
A clinical trial evaluating the efficacy of CT041 in sequential treatment after first-line therapy for advanced gastric cancer and gastroeso…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Safety of Combining Irinotecan With 5-FU, Leucovorin/Folinic Acid, Oxaliplatin, and Docetaxel Chemotherapies [Phase 1]
A Phase 1 clinical trial update evaluating the safety of a quadruple chemotherapy combination (irinotecan with 5-FU/leucovorin, oxaliplatin,…
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: Early Access Program for Zolbetuximab
It provides an update on the Early Access Program for zolbetuximab in patients with locally advanced unresectable or metastatic gastric or g…
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: Safety and Efficacy of SHR2554 Combined With Other Antitumor Therapies in Gastric or Gastro-oesophageal Junction Adenocarcinoma [Phase 2]
A Phase 2 clinical trial is assessing SHR2554 in combination with other antitumor therapies for advanced/metastatic gastric cancer and gastr…
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: The Efficacy and Safety of Iparomlimab/Tuvonralimab (Anti PD-1/CTLA-4) Combined With Albumin-bound Paclitaxel in Second-line Treatment of Patients With Advanced Gastric/Gastroesophageal Junction Adenocarcinoma [NA]
Clinical trial update for a second-line combination of Iparomlimab and Tuvonralimab with albumin-bound paclitaxel in advanced gastric or gas…
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CLINICAL_TRIALS research · 2025-09-08Clinical Trial Update: Safety and Efficacy of Glumetinib Combined With Docetaxel for Injection (Albumin-bound) in Patients With Advanced Gastric Cancer/Gastroesophageal Junction Adenocarcinoma and Other Solid Tumors [Phase 2]
Phase 2 clinical trial evaluating Glumetinib in combination with Nab-docetaxel for advanced gastric/gastroesophageal junction cancers and ot…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: MAIC of Fruquintinib Plus Paclitaxel Versus Ramucirumab Plus Paclitaxel in Advanced G/GEJ Adenocarcinoma
Clinical trial update describing a matching-adjusted indirect comparison (MAIC) of Fruquintinib plus paclitaxel versus ramucirumab plus pacl…
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: An Open Label Phase 2 Study of Total Neoadjuvant Therapy (TNT) Consisting of FLOT With Pembrolizumab and Short Radiation for Patients With Locally Advanced Gastroesophageal Junction Adenocarcinoma [Phase 2]
An open-label Phase 2 trial evaluating total neoadjuvant therapy with FLOT chemotherapy plus pembrolizumab and short radiation for locally a…
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CLINICAL_TRIALS research · 2025-08-24Clinical Trial Update: A Multicenter, Phase 3 Study of IBI343 Monotherapy Versus Treatment of Investigator's Choice in Subjects With Previously Treated, Claudin (CLDN) 18.2-positive, HER2-negative, Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 3]
Phase 3 multicenter trial evaluating IBI343 monotherapy versus investigator's choice in previously treated CLDN18.2-positive, HER2-negative …
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: Assessing Iparomlimab and Tuvonralimab in Recurrent or Metastatic MSI-H/dMMR Gastric Cancer [Phase 2]
Phase 2 clinical trial update for iparomlimab and tuvonralimab in MSI-H gastric/gastroesophageal junction adenocarcinoma; the study is curre…