Gastroesophageal Junction Adenocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Dual-target CLDN18.2/HER2 CAR-NK Cells for Advanced Gastric/GEJ Cancer [Phase 1, Phase 2]
A Phase 1/2 clinical trial is recruiting to evaluate CLDN18.2/HER2-targeted CAR-NK cells for advanced gastric cancer and advanced gastroesop…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Adebrelimab Combined With Nab-paclitaxel, Oxaliplatin and Tegafur (AOS) for Perioperative Treatment of Locally Advanced Resectable GC/GEJ [Phase 2]
This Phase 2 trial investigates adebrelimab with nab-paclitaxel, oxaliplatin and tegafur (AOS) as perioperative therapy for locally advanced…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer [Phase 1]
A Phase 1 clinical trial evaluating ASP2138 given alone or with other cancer therapies in adults with gastric adenocarcinoma, gastroesophage…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 3]
Phase 3 trial updating the design of a study comparing subcutaneous tislelizumab versus intravenous tislelizumab plus chemotherapy in unrese…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer [Phase 2]
Phase 2 trial evaluating atezolizumab with or without chemotherapy for locoregional MSI-H/dMMR gastric and gastroesophageal junction cancers…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Fruquintinib and Albumin-paclitaxel Combined With or Without PD-1 Antibody in 2nd-line Treatment of G/GEJ Adenocarcinoma
This clinical trial update describes a study evaluating fruquintinib plus albumin-bound paclitaxel with or without a PD-1 antibody as second…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial is evaluating nivolumab added to standard therapy for advanced gastric and esophageal adenocarcinomas, incl…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study of Sigvotatug Vedotin in Advanced Solid Tumors [Phase 1]
Phase 1 study of Sigvotatug Vedotin in advanced solid tumors is currently recruiting. The trial targets multiple indications, including non-…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors [Phase 1]
Phase 1 study evaluating SGN-CEACAM5C in adults with advanced solid tumors is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Safety and Efficacy of CT0494BCP in Participants With Advanced Gastric/Esophagogastric Junction Adenocarcinoma
A clinical trial update describes the planned safety and efficacy assessment of CT0494BCP in adults with advanced gastric or gastroesophagea…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma [Phase 2]
A Phase 2 clinical trial evaluating preoperative hypofractionated radiotherapy in combination with the FOLFOX regimen for esophageal or gast…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: NBTXR3, Chemotherapy, and Radiation Therapy for the Treatment of Esophageal Cancer [Phase 1]
Phase 1 trial evaluating NBTXR3 in combination with chemotherapy and radiation therapy for esophageal cancer; recruitment is ongoing across …
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Paclitaxel for the Treatment of Gastric or Gastroesophageal Cancer [Phase 1]
Phase 1 study evaluating paclitaxel for gastric cancer and gastroesophageal junction adenocarcinoma; the trial includes metastatic/stage IV …
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating ASP546C in adults with gastric/GEJ adenocarcinoma, pancreatic adenocarcinoma, or other solid tumors is…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread [Phase 1, Phase 2]
A Phase 1/2 trial evaluating the dose of Zongertinib used alone or with other therapies in HER2-positive metastatic cancers, including breas…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Nivolumab, Ipilimumab and Chemoradiation in Treating Patients With Resectable Gastric Cancer [Phase 2]
A Phase 2 clinical trial evaluating nivolumab and ipilimumab in combination with chemoradiation for resectable gastric cancer and gastroesop…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: A Phase Ib/II Study of ATG-022 Plus Pembrolizumab With/Without Chemotherapy in Participants With Claudin (CLDN) 18.2-positive, HER2-negative, Unresectable or Metastatic Gastric or Gastroesophageal Junction AdenocarcinomaUnresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 1, Phase 2]
A Phase Ib/II clinical trial evaluating ATG-022 in combination with pembrolizumab, with or without chemotherapy, for CLDN18.2-positive, HER2…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2 [Phase 3]
Phase 3 trial evaluating Sonesitatug Vedotin with Capecitabine, with or without Rilvegostomig, in advanced or metastatic Claudin18.2-express…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors [Phase 1]
Plexium, Inc. is conducting a first-in-human Phase 1 study of PLX-61639 in locally advanced or metastatic solid tumors, and the trial is cur…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial [Phase 1]
This is an early-stage (Phase 1) clinical trial evaluating the combination of DS-8201a (trastuzumab deruxtecan) and AZD6738 (camonsertib) fo…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer [Phase 3]
This Phase 3 trial is evaluating rilvegostomig in combination with a fluoropyrimidine and trastuzumab deruxtecan as first-line therapy for H…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Phase 2 Study of Trastuzumab Deruxtecan in the Neoadjuvant Treatment, or Trastuzumab Deruxtecan Plus Capecitabine Plus Durvalumab(MEDI4736) in the Preoperative and Postoperative Adjuvant Treatment for Patients With HER2 Positive Gastric and Gastroesophageal Junction Adenocarcinoma [Phase 2]
This clinical trial update describes a Phase 2 study evaluating trastuzumab deruxtecan, with or without capecitabine and durvalumab, as neoa…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study [Phase 2]
A Phase 2 trial (ROBO-CHIP) from Mayo Clinic is evaluating robotic cytoreduction followed by hyperthermic intraperitoneal chemotherapy for g…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Study Comparing BL-M05D1 With the Investigator's Choice of Treatment Regimen in Patients With Claudin (CLDN)18.2-Positive Advanced Gastric Cancer or Gastroesophageal Junction Adenocarcinoma (GC/GEJC) Who Have Received Prior First-Line Treatment [Phase 3]
ClinicalTrials.gov entry for a Phase 3 study of BL-M05D1 vs investigator's choice in CLDN18.2-positive advanced gastric cancer or gastroesop…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Prospective Study of Physical Function in Adults Who Receive Systemic Therapy for Stage I-III Gastroesophageal Cancer, FAST-GO Study
This Clinical Trials update describes the FAST-GO prospective study evaluating physical function in adults receiving systemic therapy for st…