Gastroesophageal Cancer

• CLINICAL_TRIALS research · 2026-04-24
  Clinical Trial Update: Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06) [Phase 1, Phase 2]

  This is a clinical trial update indicating that Substudy 06C is evaluating pembrolizumab in combination with chemotherapy for first-line loc…

• CLINICAL_TRIALS research · 2026-04-21
  Clinical Trial Update: Supportive Oncology Care At Home RCT [NA]

  Clinical trial update on an at-home supportive oncology care program; the study is currently active but not recruiting.

• CLINICAL_TRIALS trial_result · 2026-04-15
  Clinical Trial Update: Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma [Phase 1, Phase 2]

  Clinical trial update indicates a Phase 1/2 study of BHB810 in advanced gastric and GEJ adenocarcinoma, with the trial currently not yet rec…

• CLINICAL_TRIALS research · 2026-04-14
  Clinical Trial Update: Simvastatin Efficacy in ARID1A Mutated Advanced gastroESophageal Carcinoma Treated With Immunotherapy [Phase 2]

  Phase 2 clinical trial exploring simvastatin efficacy in ARID1A-mutated advanced gastroesophageal cancer treated with immunotherapy; current…

• CLINICAL_TRIALS trial_result · 2026-04-09
  Clinical Trial Update: A Phase 1 Study of the Safety and Tolerability of CTX-10726 [Phase 1]

  Phase 1 study update on the safety and tolerability of CTX-10726, currently recruiting across gastroesophageal cancer, hepatocellular carcin…

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• CLINICAL_TRIALS trial_result · 2026-04-01
  Clinical Trial Update: Gevokizumab With Standard of Care Anti-cancer Therapies for Metastatic Colorectal, Gastroesophageal, and Renal Cancers [Phase 1]

  This Phase 1 trial evaluates gevokizumab in combination with standard-of-care anticancer therapies for metastatic colorectal cancer, gastroe…

• CLINICAL_TRIALS research · 2026-04-01
  Clinical Trial Update: Support Through Remote Observation and Nutrition Guidance Program for Individuals With Gastroesophageal Cancer [NA]

  A study evaluating a remote observation and nutrition guidance program for individuals with gastroesophageal cancer is currently recruiting.

• CLINICAL_TRIALS research · 2026-03-20
  Clinical Trial Update: Perioperative Zanidatamab and Chemotherapy for HER2 Positive Gastroesophageal Cancer [Phase 1, Phase 2]

  Phase 1/2 study evaluating perioperative zanidatamab with chemotherapy for HER2-positive gastroesophageal cancer; the trial is currently not…

• CLINICAL_TRIALS research · 2026-03-18
  Clinical Trial Update: A First-In-Human Phase I/IIa Study to Evaluate DA 3501 in Patients With Advanced Gastric or Gastro-esophageal Junction Adenocarcinoma and Pancreatic Ductal Adenocarcinoma [Phase 1]

  First-in-human phase I/IIa trial evaluating DA 3501 in advanced gastric or gastroesophageal cancer and pancreatic ductal adenocarcinoma; cur…

• CLINICAL_TRIALS research · 2026-02-27
  Clinical Trial Update: A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015) [Phase 3]

  A Phase 3 trial evaluating Sacituzumab Tirumotecan (MK-2870) in advanced/metastatic gastroesophageal adenocarcinoma is currently active but …

• CLINICAL_TRIALS trial_result · 2026-02-25
  Clinical Trial Update: PRO1107 in Patients With Advanced Solid Tumors [Phase 1, Phase 2]

  The Phase 1/2 PRO1107 trial in advanced solid tumors, including endometrial and ovarian cancers, has been terminated.

• CLINICAL_TRIALS trial_result · 2026-02-11
  Clinical Trial Update: A Systems Approach to Immunotherapy Biomarker Identification Within the Postoperative Wound-Healing Microenvironment in Patients With Gastroesophageal Cancer

  This completed clinical study uses a systems approach to identify immunotherapy biomarkers within the postoperative wound-healing microenvir…

• CLINICAL_TRIALS research · 2026-02-09
  Clinical Trial Update: Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal Cancer [Phase 2]

  Phase 2 trial evaluating neratinib in combination with chemotherapy, trastuzumab, and pembrolizumab for HER2-positive gastroesophageal cance…

• CLINICAL_TRIALS research · 2026-01-21
  Clinical Trial Update: Synergistic Effects of PD-1 Antibody and Chemotherapy/Targeted Therapy Followed by Surgery-centric Local Treatment in Patients With Limited-metastatic Gastric Cancer [Phase 2]

  Phase 2 clinical trial evaluating a PD-1 antibody in combination with chemotherapy or targeted therapy, followed by a surgery-centric local …

• CLINICAL_TRIALS research · 2026-01-15
  Clinical Trial Update: Sample Collection for Ongoing Research and Product Evaluation Study

  Natera reports an ongoing study update focused on sample collection for ongoing research and product evaluation; the trial is currently recr…

• CLINICAL_TRIALS trial_result · 2026-01-13
  Clinical Trial Update: Impact of Pretreatment Emotional Distress on Survival and the Predictive Role of Peripheral Biomarkers in Immunotherapy Response Among Gastroesophageal and Lung Cancer Patients

  A completed clinical trial investigates whether pretreatment emotional distress affects survival in patients receiving immunotherapy. It als…

• CLINICAL_TRIALS research · 2026-01-07
  Clinical Trial Update: sFOLFOXIRI in Advanced Gastroesophageal Cancer, (SAGE) [Phase 2]

  Phase 2 clinical trial update evaluating sFOLFOXIRI in advanced gastroesophageal cancer; the study is currently recruiting.

• CLINICAL_TRIALS research · 2026-01-02
  Clinical Trial Update: Imaging and Blood-Based Biomarkers for the Evaluation of Early Signs of Myocardial Injury After Thoracic Radiation Therapy

  This clinical trial update from Ohio State University Comprehensive Cancer Center describes evaluating imaging and blood-based biomarkers to…

• CLINICAL_TRIALS research · 2025-12-22
  Clinical Trial Update: REACTION (Radiation Enhanced Assessment of Combination Therapies in Immuno-ONcology) - Nivolumab or Nivolumab in Combination With Other Immuno-oncology (IO) Agents After Targeted Systemic Radiation in Patients With Advanced Esophagogastric Cancer [Phase 1, Phase 2]

  This entry covers the REACTION trial (NCT03610711) evaluating nivolumab, alone or with other immune checkpoint inhibitors, after targeted sy…

• CLINICAL_TRIALS trial_result · 2025-12-08
  Clinical Trial Update: PREACT Study: Locally Advanced Gastric Cancer, Chemoradiotherapy vs. Chemotherapy Followed by D2 Surgery and Adjuvant Chemotherapy [Phase 3]

  The PREACT Phase 3 trial comparing chemoradiotherapy versus chemotherapy followed by D2 gastrectomy and adjuvant chemotherapy for locally ad…

• CLINICAL_TRIALS research · 2025-12-04
  Clinical Trial Update: Support Through Remote Observation and Nutrition Guidance (STRONG) Program for Gastroesophageal Cancer (GEC) Patients [NA]

  A clinical trial update describes the STRONG program, which uses remote observation and nutrition guidance to support gastroesophageal cance…

• CLINICAL_TRIALS research · 2025-10-29
  Clinical Trial Update: Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients [Phase 1]

  A Phase 1 clinical trial evaluating the combination of neratinib and fam-trastuzumab deruxtecan for advanced gastric and gastroesophageal ca…

• CLINICAL_TRIALS trial_result · 2025-10-09
  Clinical Trial Update: A Study of DKN-01 in Combination With Tislelizumab ± Chemotherapy in Patients With Gastric or Gastroesophageal Cancer [Phase 2]

  Phase 2 study of DKN-01 in combination with tislelizumab, with or without chemotherapy, in gastric and gastroesophageal cancers was terminat…

• CLINICAL_TRIALS trial_result · 2025-10-08
  Clinical Trial Update: Futibatinib in Patients With Specific FGFR Aberrations [Phase 2]

  Taiho Oncology reports a Phase 2 trial of futibatinib in patients with FGFR aberrations across advanced cancers. The study (NCT04189445) was…

• CLINICAL_TRIALS withdrawal · 2025-09-11
  Clinical Trial Update: A Phase II Study Evaluating an Organ Preservation Strategy Using Immune Checkpoint Blockade for Participants With Primary Colorectal or Gastroesophageal Cancer [Phase 2]

  A Phase II study evaluating an organ-preservation strategy using immune checkpoint blockade for primary colorectal or gastroesophageal cance…