Gastroesophageal Adenocarcinoma

• CLINICAL_TRIALS trial_result · 2025-12-24
  Clinical Trial Update: A Phase I Study of [177Lu]Lu-FF58 in Patients With Advanced Solid Tumors. [Phase 1]

  A Phase I study of [177Lu]Lu-FF58 in patients with advanced solid tumors was terminated. The sponsor was Novartis Pharmaceuticals, and the t…

• CLINICAL_TRIALS trial_result · 2025-12-01
  Clinical Trial Update: Basket Trial Exploring the Efficacy and Safety of the Combination of Niraparib and Dostarlimab [Phase 2]

  A Phase 2 basket trial evaluating the combination of niraparib and dostarlimab across multiple cancers has been terminated.

• CLINICAL_TRIALS trial_result · 2025-11-28
  Clinical Trial Update: Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015) [Phase 3]

  Phase 3 trial evaluating lenvatinib plus pembrolizumab and chemotherapy in advanced/metastatic gastroesophageal adenocarcinoma; results were…

• CLINICAL_TRIALS trial_result · 2025-11-28
  Clinical Trial Update: Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015) [Phase 3]

  Phase 3 trial assessing lenvatinib plus pembrolizumab plus chemotherapy in advanced/metastatic gastroesophageal adenocarcinoma has completed…

• CLINICAL_TRIALS trial_result · 2025-10-10
  Clinical Trial Update: Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins. [EARLY_Phase 1]

  An early-phase study evaluating the Ga-68 labeled FF58 radiotracer in selected solid tumors overexpressing integrins has been terminated.

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• CLINICAL_TRIALS trial_result · 2025-09-12
  Clinical Trial Update: A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer [Phase 2]

  Phase 2 study evaluating ZW25 (zanidatamab) in combination chemotherapy for HER2-expressing gastrointestinal cancers, including gastroesopha…

• CLINICAL_TRIALS trial_result · 2025-03-18
  Clinical Trial Update: CAPOX + Bevacizumab + Tislelizumab Treating PD-L1 CPS < 5 Locally Advanced or Metastatic GEA [Phase 2]

  A Phase 2 trial evaluating CAPOX plus bevacizumab and tislelizumab in first-line advanced gastroesophageal adenocarcinoma with PD-L1 CPS < 5…

• CLINICAL_TRIALS trial_result · 2023-09-13
  Clinical Trial Update: A Study of a Personalized Neoantigen Cancer Vaccine [Phase 1, Phase 2]

  Clinical trial update for a personalized neoantigen cancer vaccine completed across Phase 1 and Phase 2.

• CLINICAL_TRIALS trial_result · 2021-04-08
  Clinical Trial Update: PANGEA-IMBBP: Personalized Antibodies for Gastro-Esophageal Adenocarcinoma - A 1st Pilot Metastatic Trial of Biologics Beyond Progression [Phase 2]

  Phase 2 pilot study assessing personalized antibodies for metastatic gastro-esophageal adenocarcinoma (biologics beyond progression).

• CLINICAL_TRIALS trial_result · 2020-11-17
  Clinical Trial Update: MEGA (Met or EGFR Inhibition in Gastroesophageal Adenocarcinoma): FOLFOX Alone or in Combination With AMG 102 or Panitumumab as First-line Treatment in Patients With Advanced Gastroesophageal Adenocarcinoma [Phase 2]

  Phase 2 trial evaluating FOLFOX alone or with AMG 102 or panitumumab as first-line treatment for advanced gastroesophageal adenocarcinoma; s…

• CLINICAL_TRIALS trial_result · 2019-09-20
  Clinical Trial Update: MLN1117 in Combination With Docetaxel, Paclitaxel, and Other Investigational Anticancer Agents to Treat Participants With Gastric and Gastroesophageal Adenocarcinoma [Phase 1]

  Phase 1 trial of MLN1117 in combination with docetaxel, paclitaxel, and other investigational anticancer agents in advanced/metastatic gastr…

• CLINICAL_TRIALS trial_result · 2018-04-03
  Clinical Trial Update: Phase II Study of Cabazitaxel in Refractory Metastatic Gastric or Gastroesophageal Adenocarcinoma [Phase 2]

  Phase II trial of cabazitaxel for refractory metastatic gastric adenocarcinoma and gastroesophageal adenocarcinoma completed; results were p…

• CLINICAL_TRIALS trial_result · 2016-08-15
  Clinical Trial Update: Alisertib in Adults With Nonhematological Malignancies, Followed by Alisertib in Lung, Breast, Head and Neck or Gastroesophageal Malignancies [Phase 1, Phase 2]

  Phase 1/Phase 2 trial results update for alisertib in adults with advanced nonhematological malignancies, including non-small cell lung canc…

• CLINICAL_TRIALS trial_result · 2012-12-18
  Clinical Trial Update: Docetaxel + Oxaliplatin + S-1 in Potentially Operable Gastric or Gastroesophageal Adenocarcinoma [Phase 2]

  A Phase 2 trial evaluating the combination of docetaxel, oxaliplatin, and S-1 in potentially operable gastric or gastroesophageal adenocarci…

• CLINICAL_TRIALS trial_result · 2012-11-28
  Clinical Trial Update: Panitumumab, Paclitaxel, Carboplatin and 5FU in the Treatment of Potentially Resectable Gastroesophageal Adenocarcinoma [Phase 2]

  Phase 2 clinical trial evaluating panitumumab with paclitaxel, carboplatin and 5-FU in potentially resectable gastroesophageal adenocarcinom…