Gastroesophageal Adenocarcinoma

• CLINICAL_TRIALS research · 2026-04-24
  Clinical Trial Update: Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06) [Phase 1, Phase 2]

  This is a clinical trial update indicating that Substudy 06C is evaluating pembrolizumab in combination with chemotherapy for first-line loc…

• CLINICAL_TRIALS research · 2026-04-23
  Clinical Trial Update: A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma [Phase 2]

  Phase 2 clinical trial evaluating novel agents or combinations as perioperative treatment for locally advanced, resectable gastroesophageal …

• CLINICAL_TRIALS research · 2026-04-22
  Clinical Trial Update: A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers [Phase 1]

  This update details a Phase 1 study evaluating DISP-10 in advanced gastrointestinal cancers, with the trial currently not yet recruiting.

• CLINICAL_TRIALS research · 2026-04-17
  Clinical Trial Update: A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers [Phase 3]

  Phase 3 clinical trial update for zanidatamab in combination with chemotherapy with or without tislelizumab in HER2-positive advanced or met…

• CLINICAL_TRIALS research · 2026-04-07
  Clinical Trial Update: AACR Adaptive Biomarker-Driven Organ Preservation Trial in Gastroesophageal Adenocarcinomas [Phase 2]

  A Phase 2 adaptive biomarker-driven trial focusing on organ preservation for gastroesophageal adenocarcinoma; the study is currently not rec…

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• CLINICAL_TRIALS research · 2026-03-10
  Clinical Trial Update: Response Adapted Neoadjuvant Therapy in Gastroesophageal Cancers (RANT-GC Trial) [Phase 1]

  This update announces the Phase 1 RANT-GC trial evaluating response-adapted neoadjuvant therapy for gastroesophageal cancer, currently recru…

• CLINICAL_TRIALS research · 2026-03-04
  Clinical Trial Update: Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels [Phase 2]

  Phase 2 Yale-sponsored trial evaluating adding sequential cytoreductive intervention to standard-of-care therapy for metastatic foregut aden…

• CLINICAL_TRIALS research · 2026-02-27
  Clinical Trial Update: A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015) [Phase 3]

  A Phase 3 trial evaluating Sacituzumab Tirumotecan (MK-2870) in advanced/metastatic gastroesophageal adenocarcinoma is currently active but …

• CLINICAL_TRIALS research · 2026-02-04
  Clinical Trial Update: Zanidatamab in Combination With Pembrolizumab and Chemotherapy in HER2 and PD-L1 Positive Metastatic Gastroesophageal Adenocarcinoma (GEA) Patients [Phase 2]

  Phase 2 clinical trial evaluating zanidatamab in combination with pembrolizumab and chemotherapy as first-line therapy for metastatic gastro…

• CLINICAL_TRIALS research · 2026-01-30
  Clinical Trial Update: Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma [Phase 2]

  Phase 2 clinical trial update evaluating paclitaxel and ramucirumab with or without zanidatamab in HER2-positive advanced gastroesophageal a…

• CLINICAL_TRIALS research · 2026-01-27
  Clinical Trial Update: A First-in-Human Study Using BDC-4182 as a Single Agent in Advanced Gastric and Gastroesophageal Cancer [Phase 1, Phase 2]

  Bolt Biotherapeutics is conducting a first-in-human Phase 1/2 study of BDC-4182 as a single-agent therapy in metastatic gastric adenocarcino…

• CLINICAL_TRIALS research · 2026-01-13
  Clinical Trial Update: Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease [Phase 1]

  Phase 1 clinical trial update evaluating a Personalized Cancer Vaccine (PCV) strategy in patients with solid tumors, specifically muscle-inv…

• CLINICAL_TRIALS research · 2025-12-10
  Clinical Trial Update: Safety of Trifluridine/Tipiracil in Patients With Dihydropyrimidine Dehydrogenase Deficiency Diagnosed With Metastatic Colorectal or Gastroesophageal Cancer [Phase 2]

  Phase 2 trial investigating the safety of trifluridine/tipiracil (Lonsurf) in patients with dihydropyrimidine dehydrogenase (DPD) deficiency…

• CLINICAL_TRIALS research · 2025-10-29
  Clinical Trial Update: Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab [Phase 1]

  A Phase 1 clinical trial update shows ABBV-400 alone or with bevacizumab being studied in adults with advanced solid tumors, including non-s…

• CLINICAL_TRIALS research · 2025-07-30
  Clinical Trial Update: A Clinical Trial Evaluating TQB2102 for Injection in Combination With Behmosubaisumab/Payamprolizumab With or Without Chemotherapy in Unresectable Locally Advanced, Recurrent, or Metastatic Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastroesophageal Adenocarcinoma [Phase 2]

  Phase 2 clinical trial evaluating TQB2102 in combination with Behmosubaisumab and Payamprolizumab, with or without chemotherapy, for unresec…

• CLINICAL_TRIALS research · 2025-06-24
  Clinical Trial Update: Phase II Study of Short Course FOLFOX Chemotherapy With Either Nivolumab or Nivolumab + Radiation in the First Line Treatment of Metastatic or Unresectable Gastroesophageal Cancers (BMS Protocol CA209-76L) [Phase 2]

  Phase II clinical trial evaluating short-course FOLFOX chemotherapy with either nivolumab or nivolumab plus radiation as first-line treatmen…

• CLINICAL_TRIALS research · 2025-05-14
  Clinical Trial Update: Molecular Characteristics of Gastroesophageal Adenocarcinoma (MOCHA): A Prospective Feasibility Study

  The MOCHA study is a prospective feasibility study evaluating molecular characteristics of gastroesophageal adenocarcinoma. It is currently …