Familial Hypercholesterolemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2015-09-29Clinical Trial Update: Reduction of Low-Density Lipoprotein Cholesterol (LDL-C) With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study [Phase 2]
Phase 2 trial update on PCSK9 inhibition showing reduction of LDL cholesterol in individuals with heterozygous familial hypercholesterolemia…
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CLINICAL_TRIALS trial_result · 2015-09-22Clinical Trial Update: Study of the Safety and Efficacy of REGN727/SAR236553 in Patients With HeFH Hypercholesterolemia [Phase 2]
Phase 2 study evaluating the safety and efficacy of evolocumab (REGN727/SAR236553) in heterozygous familial hypercholesterolemia; the trial …
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CLINICAL_TRIALS trial_result · 2015-09-04Clinical Trial Update: Safety and Efficacy of the DALI LDL-adsorber and MONET Lipoprotein Filter
Clinical trial update reporting safety and efficacy results for the DALI LDL-adsorber and MONET Lipoprotein Filter in patients with familial…
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CLINICAL_TRIALS trial_result · 2015-06-24Clinical Trial Update: Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration [Phase 2]
Phase 2 clinical trial update evaluating mipomersen (ISIS 301012) and its effect on liver fat content in lipid metabolism disorders and hype…
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CLINICAL_TRIALS trial_result · 2015-06-02Clinical Trial Update: Atorvastatin Three Year Pediatric Study [Phase 3]
Phase 3 pediatric study of atorvastatin for familial hypercholesterolemia has completed with results posted in 2015.
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CLINICAL_TRIALS trial_result · 2015-04-22Clinical Trial Update: Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone. [Phase 3]
Phase 3 study comparing the anti-atherosclerotic effect of torcetrapib added to atorvastatin versus atorvastatin alone has completed.
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CLINICAL_TRIALS trial_result · 2015-02-02Clinical Trial Update: An Study to Evaluate Rosuvastatin in Children and Adolescents With Familial Hypercholesterolaemia [Phase 3]
Phase 3 trial evaluating rosuvastatin in children and adolescents with familial hypercholesterolemia has completed and posted results.
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CLINICAL_TRIALS trial_result · 2014-08-26Clinical Trial Update: Relationships Between Plasma PCSK9 Levels, LDL-cholesterol Concentrations and Lipoprotein (a) Levels in Familial Hypercholesterolemia
This completed clinical trial examined the relationships among plasma PCSK9 levels, LDL-cholesterol concentrations, and lipoprotein(a) level…
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CLINICAL_TRIALS trial_result · 2014-02-11Clinical Trial Update: A Study of the Safety and Efficacy of Patients With Familial Hypercholesterolaemia Taking Colesevelam as add-on Therapy to Their Existing Medication [Phase 4]
A Phase 4 study evaluated the safety and efficacy of adding colesevelam to patients' existing therapy for familial hypercholesterolemia and …
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CLINICAL_TRIALS trial_result · 2014-01-29Clinical Trial Update: Efficacy of a New Symbiotic Formulation in Children With Familial Hypercholesterolemia [Phase 1, Phase 2]
This trial update reports on the efficacy results from Phase 1/2 studies of a new symbiotic formulation in children with familial hyperchole…
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CLINICAL_TRIALS trial_result · 2014-01-29Clinical Trial Update: Low-Density Lipoprotein (LDL) Apheresis Using H.E.L.P. Therapy [Phase 4]
A Phase 4 clinical trial evaluated LDL apheresis using H.E.L.P. therapy for familial hypercholesterolemia; results were posted after complet…
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CLINICAL_TRIALS trial_result · 2013-12-17Clinical Trial Update: Effects of Low-density Lipoprotein (LDL) Apheresis on Inflammatory and Lipid Markers
A completed trial update evaluated the effects of LDL apheresis on inflammatory and lipid markers in familial hypercholesterolemia. The tria…
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CLINICAL_TRIALS trial_result · 2013-12-04Clinical Trial Update: A Study of Extended-release (ER) Niacin/Laropiprant in Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0524A-158) [Phase 1]
Phase 1 trial of extended-release niacin/laropiprant in adolescents with heterozygous familial hypercholesterolemia was terminated; results …
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CLINICAL_TRIALS trial_result · 2013-11-26Clinical Trial Update: Effect of Weight Loss on Cholesterol Metabolism in Hereditary Hypercholesterolemias and Overweight or Obesity. [NA]
A completed clinical trial evaluating how weight loss influences cholesterol metabolism in individuals with hereditary hypercholesterolemias…
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CLINICAL_TRIALS trial_result · 2013-08-27Clinical Trial Update: Flaxseed Compared With Placebo in Patients With Hypercholesterolemia [Phase 3]
Phase 3 trial comparing flaxseed with placebo in patients with familial or severe hypercholesterolemia has completed.
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CLINICAL_TRIALS trial_result · 2013-05-30Clinical Trial Update: Amlodipine/Atorvastatin (Caduet®) Drug Use Investigation (Regulatory Post Marketing Commitment Plan)
Clinical trial update for Amlodipine/Atorvastatin (Caduet) under regulatory post-marketing commitments; study completed with results posted …
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CLINICAL_TRIALS trial_result · 2013-04-05Clinical Trial Update: Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia [Phase 2]
Open-label extension study of ISIS 301012 (Mipomersen) for familial hypercholesterolemia has completed with results posted in 2013.
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CLINICAL_TRIALS trial_result · 2013-03-21Clinical Trial Update: Efficacy and Safety Study of ISIS 301012 (Mipomersen) as Add-on in Familial Hypercholesterolemic Patients With Coronary Artery Disease [Phase 3]
Phase 3 trial evaluating mipomersen (ISIS-301012) as add-on therapy in patients with heterozygous familial hypercholesterolemia and coronary…
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CLINICAL_TRIALS trial_result · 2012-04-27Clinical Trial Update: NHLBI Type II Coronary Intervention Study [Phase 3]
This update notes that the NHLBI Type II Coronary Intervention Study, a Phase 3 clinical trial, has completed.
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CLINICAL_TRIALS trial_result · 2011-11-22Clinical Trial Update: Multiple Ascending Dose Study of SPC5001 in Treatment of Healthy Subjects and Subjects With FH [Phase 1]
A Phase 1 multiple ascending-dose study of SPC5001 in healthy subjects and individuals with familial hypercholesterolemia was terminated.
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CLINICAL_TRIALS trial_result · 2011-01-06Clinical Trial Update: Influence of Organic Anion Transporting Polypeptide1B1(OATP1B1) Genotype on Rosuvastatin PK, PD and Lipid Profiles [Phase 4]
Phase 4 trial update examining how OATP1B1 genotype influences rosuvastatin pharmacokinetics, pharmacodynamics, and lipid responses.
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CLINICAL_TRIALS trial_result · 2010-01-26Clinical Trial Update: Efficacy and Safety of Colesevelam in Pediatric Patients With Genetic High Cholesterol [Phase 4]
Post-marketing Phase 4 trial evaluating the efficacy and safety of colesevelam in pediatric patients with familial hypercholesterolemia.
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CLINICAL_TRIALS trial_result · 2009-09-02Clinical Trial Update: Carotid IMT (Intima Media Thickening) Study (0524A-041)(TERMINATED) [Phase 3]
A Phase 3 trial examining carotid intima-media thickness in patients with hypercholesterolemia (familial) sponsored by Merck was terminated.…
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CLINICAL_TRIALS trial_result · 2009-08-03Clinical Trial Update: To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED) [Phase 3]
A Phase 3 trial assessed the lipid-lowering effects of combining ezetimibe/simvastatin with extended-release niacin in patients with Type II…
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CLINICAL_TRIALS trial_result · 2009-07-20Clinical Trial Update: PLUTO: Pediatric Lipid-redUction Trial of rOsuvastatin [Phase 3]
Phase 3 PLUTO trial evaluated rosuvastatin for lipid reduction in children with familial hypercholesterolemia; the results were posted in Ju…