Familial Hypercholesterolemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-08-06Clinical Trial Results: A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids [Phase 3]
Phase 3 trial results for Enlicitide Decanoate (MK-0616), an oral PCSK9 inhibitor, in adults with hypercholesterolemia; study completed with…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Specified Drug-use Survey of Leqvio for s.c. Injection.
This clinical trial update reports a specified drug-use survey of Leqvio (inclisiran) for subcutaneous injection, with the study currently a…
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: Pediatric Reporting of Adult-Onset Genomic Results [EARLY_Phase 1]
Geisinger Clinic's EARLY Phase 1 trial update reports completion and posting of results regarding pediatric reporting of adult-onset genomic…
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CLINICAL_TRIALS trial_result · 2026-02-24Clinical Trial Update: A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017/CORALreef HeFH) [Phase 3]
Phase 3 trial update for Enlicitide Decanoate (MK-0616), an oral PCSK9 inhibitor, in adults with heterozygous familial hypercholesterolemia,…
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CLINICAL_TRIALS trial_result · 2025-12-30Clinical Trial Update: Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Patients With Familial Hypercholesterolemia [NA]
The completed trial evaluated a Brazilian cardioprotective diet combined with phytosterols and krill oil in patients with familial hyperchol…
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CLINICAL_TRIALS trial_result · 2025-12-24Clinical Trial Update: Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients [Phase 1]
Phase 1 study of ARO-ANG3 in healthy volunteers and dyslipidemic patients has completed; the update provides status of the trial.
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying Therapies [Phase 3]
Phase 3 study evaluating a fixed-dose combination of obicetrapib and ezetimibe added to existing lipid-modifying therapy has completed. Resu…
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CLINICAL_TRIALS trial_result · 2025-09-19Clinical Trial Update: Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapies [Phase 3]
Phase 3 randomized study evaluating obicetrapib added to maximum tolerated lipid-modifying therapies has completed, with results posted.
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CLINICAL_TRIALS trial_result · 2025-09-12Clinical Trial Update: A VSA003 Phase 1 Study in Chinese Adult Healthy Volunteers [Phase 1]
Phase 1 clinical trial update reports completion of a Phase 1 study of VSA003 in Chinese adult healthy volunteers.
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CLINICAL_TRIALS trial_result · 2025-09-10Clinical Trial Update: A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids [Phase 3]
Phase 3 trial update for Enlicitide Decanoate (MK-0616), an oral PCSK9 inhibitor, in adults with hypercholesterolemia, including familial hy…
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CLINICAL_TRIALS trial_result · 2025-09-10Clinical Trial Update: Unravelling the Impact of Diet on Cardiovascular Health in Heterozygous Familial Hypercholesterolemia. [NA]
A completed clinical trial from Laval University examined the impact of diet on cardiovascular health in people with heterozygous familial h…
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CLINICAL_TRIALS trial_result · 2025-06-17Clinical Trial Update: Patterns of Inclisiran Use in the Real World: An Analysis of US Databases
This clinical trial update analyzes real-world use patterns of inclisiran in US databases for patients with atherosclerotic cardiovascular d…
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CLINICAL_TRIALS trial_result · 2025-06-11Clinical Trial Update: Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies. [Phase 3]
A Phase 3 trial evaluating Obicetrapib in patients with familial hypercholesterolemia on maximally tolerated lipid-modifying therapy has com…
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CLINICAL_TRIALS trial_result · 2025-04-04Clinical Trial Update: Impact of Rosuvastatin Doses on LDL Levels, CPK Levels and Aspartate Aminotransferase Levels [NA]
A completed clinical trial evaluated the effects of different rosuvastatin doses on LDL cholesterol and liver/muscle safety markers (AST and…
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CLINICAL_TRIALS trial_result · 2024-11-26Clinical Trial Update: Clinical Decision Support for Familial Hypercholesterolemia [NA]
This is an update on a clinical trial evaluating clinical decision support for familial hypercholesterolemia. The study is currently recruit…
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CLINICAL_TRIALS trial_result · 2024-11-21Clinical Trial Update: Long Term Post Marketing Specified Drug Use Result Survey for Evolocumab in Japan
A long-term post-marketing specified drug use survey for evolocumab conducted in Japan has completed.
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CLINICAL_TRIALS trial_result · 2024-10-21Clinical Trial Update: Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia. [NA]
The clinical trial investigating how diet affects cardiovascular health in individuals with treated heterozygous familial hypercholesterolem…
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CLINICAL_TRIALS trial_result · 2024-08-21Clinical Trial Update: The Use of Mobile Health Technology and Behavioral Economics to Encourage Adherence in Adolescents [NA]
A completed clinical trial evaluating a mobile health platform using behavioral economics to improve medication adherence in adolescents wit…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578) [Phase 3]
A Phase 3 trial comparing ezetimibe plus simvastatin versus simvastatin alone for progression of carotid artery atherosclerosis has complete…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Investigational Drug in Patients With Hypercholesterolemia or in Patients With Sitosterolemia (0653-026)(COMPLETED) [Phase 3]
A Phase 3 clinical trial of an Organon investigational drug for familial hypercholesterolemia and sitosterolemia was terminated.
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CLINICAL_TRIALS trial_result · 2024-07-18Clinical Trial Update: A Real-world Study of Inclisiran Adherence, Treatment Patterns, Patient Characteristics, and Effectiveness in ASCVD Patients With Hypercholesterolemia, ASCVD-risk Equivalent Patients With Hypercholesterolemia and Familial Hypercholesterolemia
This completed real-world study evaluated adherence, treatment patterns, patient characteristics, and effectiveness of Inclisiran in patient…
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CLINICAL_TRIALS trial_result · 2024-05-10Clinical Trial Update: Ezetimibe (SCH 58235) Taken With Either Atorvastatin or Simvastatin in Participants With Familial Hypercholesterolemia (MK-0653-018) [Phase 3]
This Phase 3 study MK-0653-018 assessed ezetimibe taken with either atorvastatin or simvastatin in individuals with familial hypercholestero…
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CLINICAL_TRIALS trial_result · 2024-03-06Clinical Trial Update: Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C [Phase 3]
Phase 3 trial update evaluating long-term dosing of inclisiran in high cardiovascular risk patients with elevated LDL-C; study completed wit…
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CLINICAL_TRIALS trial_result · 2023-12-06Clinical Trial Update: A Study of the Efficacy and Safety of Enclitide Chloride (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-008) [Phase 2]
Phase 2 trial evaluating the efficacy and safety of Enclitide Chloride (MK-0616) as an oral PCSK9 inhibitor in adults with hypercholesterole…
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CLINICAL_TRIALS trial_result · 2023-03-24Clinical Trial Update: An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesterol [Phase 2]
Phase 2 extension trial update for inclisiran in participants with cardiovascular disease and high cholesterol; study completed with results…