Familial Hypercholesterolemia
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CLINICAL_TRIALS trial_result · 2026-08-06Clinical Trial Results: A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids [Phase 3]
Phase 3 trial results for Enlicitide Decanoate (MK-0616), an oral PCSK9 inhibitor, in adults with hypercholesterolemia; study completed with…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Real-World Study of Long-Term Adherence and Persistence to Inclisiran, Evolocumab, and Alirocumab
This real-world clinical trial update reports on long-term adherence and persistence to inclisiran, evolocumab, and alirocumab among patient…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Specified Drug-use Survey of Leqvio for s.c. Injection.
This clinical trial update reports a specified drug-use survey of Leqvio (inclisiran) for subcutaneous injection, with the study currently a…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Comparing Direct vs Indirect Methods for Cascade Screening [NA]
A clinical trial is evaluating direct versus indirect cascade screening methods for two genetic conditions (Long QT Syndrome and Familial Hy…
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: Pediatric Reporting of Adult-Onset Genomic Results [EARLY_Phase 1]
Geisinger Clinic's EARLY Phase 1 trial update reports completion and posting of results regarding pediatric reporting of adult-onset genomic…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias [Phase 1]
The trial is a Phase 1 safety and tolerability study of CTX310 in participants with refractory dyslipidemias. It is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Study of the Determinants of Coronary Atherosclerosis in Familial Hypercholesterolemia (ATHERO-FH Study) [NA]
Enrollment is ongoing for the ATHERO-FH Study, a clinical trial investigating determinants of coronary atherosclerosis in people with famili…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: The ORIGIN-FH Study [NA]
The ORIGIN-FH clinical trial is currently recruiting to study familial hypercholesterolemia, including heterozygous and homozygous forms.
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Improving Diagnosis and Clinical Management of Familial Hypercholesterolemia Through Integrated Machine Learning, Implementation Science, and Behavioral Economics [NA]
This University of Pennsylvania-led study aims to improve diagnosis and management of familial hypercholesterolemia using machine learning, …
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: EAS Familial Hypercholesterolaemia Studies Collaboration
This entry notes an ongoing Imperial College London-led clinical trial focusing on familial hypercholesterolemia, currently recruiting parti…
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CLINICAL_TRIALS trial_result · 2026-02-24Clinical Trial Update: A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017/CORALreef HeFH) [Phase 3]
Phase 3 trial update for Enlicitide Decanoate (MK-0616), an oral PCSK9 inhibitor, in adults with heterozygous familial hypercholesterolemia,…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection. [NA]
Clinical trial update for NCT05614219, a study at Odense University Hospital focusing on nudging detection for familial hypercholesterolemia…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Screening for Familial Hypercholesterolemia in Children [NA]
This clinical trial is designed to screen children for familial hypercholesterolemia. The study is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: Penn Family Screening for Familial Hypercholesterolemia [NA]
Northwestern University is enrolling participants by invitation in a clinical trial for familial hypercholesterolemia.
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Effect of Breastfeeding on Lipid Profile and Cardiovascular Risk Markers in Women With Familial Hypercholesterolemia
This entry describes a registered clinical trial investigating how breastfeeding affects lipid profiles and cardiovascular risk markers in w…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: 2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH) [Phase 2]
Phase 2 clinical trial investigating 2-Hydroxybenzylamine (2-HOBA) to reduce HDL modification and improve HDL function in familial hyperchol…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Improved Diagnosis of Familial Hypercholesterolemia Across the Northland (ID-FH) [Phase 3]
Phase 3 clinical trial update on improved diagnosis of familial hypercholesterolemia; the study is currently active but not recruiting.
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FDA label_change · 2026-01-09FDA Approved: NEXLETOL — Supplemental Application (Esperion Therapeutics, Inc.)
The FDA approved a supplemental application for Nexletol (bempedoic acid) from Esperion Therapeutics, Inc., expanding the drug's labeling.
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry
A multicenter registry in Brazil's public health system aims to improve care for hereditary cardiovascular diseases by enrolling patients ac…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH) [NA]
This clinical trial is evaluating an adapted Brazilian cardioprotective diet with phytosterols and krill oil for familial hypercholesterolem…
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CLINICAL_TRIALS trial_result · 2025-12-30Clinical Trial Update: Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Patients With Familial Hypercholesterolemia [NA]
The completed trial evaluated a Brazilian cardioprotective diet combined with phytosterols and krill oil in patients with familial hyperchol…
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CLINICAL_TRIALS trial_result · 2025-12-24Clinical Trial Update: Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic Patients [Phase 1]
Phase 1 study of ARO-ANG3 in healthy volunteers and dyslipidemic patients has completed; the update provides status of the trial.
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Collaborative Approach to Reach Everyone With Familial Hypercholesterolemia (CARE-FH) [NA]
An ongoing clinical trial called CARE-FH, sponsored by Geisinger Clinic, is enrolling by invitation to study familial hypercholesterolemia.
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia [Phase 3]
A Phase 3 clinical trial evaluating the efficacy and safety of inclisiran in children with heterozygous familial hypercholesterolemia is cur…
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FDA label_change · 2025-10-09FDA Approved: PRALUENT — Supplemental Application (Regeneron Pharmaceuticals, Inc.)
FDA approved a supplemental application for PRALUENT (alirocumab) submitted by Regeneron, resulting in changes to the product labeling.