Familial Hypercholesterolemia
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CLINICAL_TRIALS trial_result · 2022-07-19Clinical Trial Update: Alirocumab and Plaque Burden In Familial Hypercholesterolaemia [Phase 4]
Phase 4 trial update on alirocumab and plaque burden in familial hypercholesterolemia has completed.
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CLINICAL_TRIALS trial_result · 2022-01-14Clinical Trial Update: Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia) [Phase 3]
Phase 3 trial evaluating safety, tolerability and efficacy of evolocumab in children with familial hypercholesterolemia; study completed wit…
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CLINICAL_TRIALS trial_result · 2022-01-14Clinical Trial Update: Evaluating the Efficacy of Pediatric Lipid Screening Alerts [NA]
A completed pediatric trial evaluating lipid screening alerts to improve identification or management of high cholesterol in children; resul…
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CLINICAL_TRIALS trial_result · 2021-04-01Clinical Trial Update: Impact of LDL-cholesterol Lowering on Platelet Activation [Phase 4]
Phase 4 trial examining the impact of LDL-cholesterol lowering on platelet activation in familial hypercholesterolemia was terminated with r…
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CLINICAL_TRIALS trial_result · 2020-07-15Clinical Trial Update: Trial Assessing Efficacy, Safety and Tolerability of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition in Paediatric Subjects With Genetic Low-Density Lipoprotein (LDL) Disorders [Phase 3]
Phase 3 trial assessing PCSK9 inhibition in paediatric patients with genetic LDL disorders has completed; results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-07-02Clinical Trial Update: A Study to Determine the Safety, Tolerability, and Efficacy of SHR-1209 in Patients With Familial Hypercholesterolemia [Phase 2]
Phase 2 clinical trial assessing safety, tolerability, and efficacy of SHR-1209 in patients with familial hypercholesterolemia.
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CLINICAL_TRIALS trial_result · 2019-05-17Clinical Trial Update: Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C) [Phase 2]
Phase 2 trial evaluating ALN-PCSSC treatment on LDL-C in patients with atherosclerotic cardiovascular disease and familial hypercholesterole…
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CLINICAL_TRIALS trial_result · 2019-05-13Clinical Trial Update: Effect of Omega-3 Fatty Acid on Endothelial Function [Phase 3]
Phase 3 trial update on omega-3 fatty acids evaluating endothelial function in familial hypercholesterolemia.
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CLINICAL_TRIALS trial_result · 2019-03-14Clinical Trial Update: A Study of the Safety and Efficacy of Two Different Regimens of Mipomersen in Patients With Familial Hypercholesterolemia and Inadequately Controlled Low-Density Lipoprotein Cholesterol [Phase 3]
Phase 3 trial evaluating two regimens of mipomersen in patients with familial hypercholesterolemia and inadequately controlled LDL cholester…
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CLINICAL_TRIALS trial_result · 2019-01-28Clinical Trial Update: Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders [Phase 2, Phase 3]
Amgen’s long-term trial of a PCSK9 inhibitor in subjects with familial hypercholesterolemia has completed Phase 2/Phase 3 and results have b…
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CLINICAL_TRIALS trial_result · 2018-12-04Clinical Trial Update: A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-833) [Phase 3]
A completed Phase 3 trial assessing the long-term safety and tolerability of MK-0653H in Japanese participants with hypercholesterolemia; re…
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CLINICAL_TRIALS trial_result · 2018-06-20Clinical Trial Update: Effects of Soy Protein on Cholesterol Levels in Children Affected With Familial Hypercholesterolemia [NA]
This completed clinical trial studied the effects of soy protein on cholesterol levels in children with heterozygous familial hypercholester…
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CLINICAL_TRIALS trial_result · 2018-05-11Clinical Trial Update: Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial Hypercholesterolemia [Phase 3]
Phase 3 long-term follow-on study of lomitapide in patients with homozygous familial hypercholesterolemia. Results from the completed study …
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CLINICAL_TRIALS trial_result · 2017-12-07Clinical Trial Update: Familial Hypercholesterolemia in Turkey (A-HIT2)
Completed clinical trial in Turkey (A-HIT2) investigating familial hypercholesterolemia and atherosclerosis. No specific drug names are list…
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CLINICAL_TRIALS trial_result · 2017-10-16Clinical Trial Update: Aortic Stenosis in Subjects With Heterozygous Familial Hypercholesterolemia on Prolonged Treatment With Statins
Clinical trial update regarding aortic stenosis in subjects with heterozygous familial hypercholesterolemia on prolonged statin therapy. The…
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CLINICAL_TRIALS trial_result · 2016-08-03Clinical Trial Update: Dose-escalating Safety Study of ISIS 301012 in Homozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy [Phase 2]
A Phase 2 dose-escalation safety study evaluating ISIS 301012 in patients with familial hypercholesterolemia on lipid-lowering therapy has c…
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CLINICAL_TRIALS trial_result · 2016-08-03Clinical Trial Update: Study of ISIS 301012 (Mipomersen) in Heterozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy [Phase 2]
A phase 2 trial of mipomersen in patients with familial hypercholesterolemia on lipid-lowering therapy has completed.
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CLINICAL_TRIALS trial_result · 2016-06-30Clinical Trial Update: Postprandial Response After Intake of Meals With Different Fatty Acid Composition [NA]
A completed University of Oslo study evaluated postprandial lipid and metabolic responses after meals with different fatty acid compositions…
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CLINICAL_TRIALS trial_result · 2016-05-20Clinical Trial Update: Detection of Familial Hypercholesterolaemia in Cardiovascular Disease Registry
A completed registry update from University College London evaluates the detection of Familial Hypercholesterolemia in patients with cardiov…
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CLINICAL_TRIALS trial_result · 2016-03-08Clinical Trial Update: Effects of LDL Apheresis System on the Expression of Genes Involved in Lipoprotein Metabolism and Inflammation in Homozygotes for Familial Hypercholesterolemia [NA]
A clinical trial investigated how an LDL apheresis system influences gene expression related to lipoprotein metabolism and inflammation in h…
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CLINICAL_TRIALS trial_result · 2016-02-18Clinical Trial Update: Hyperapo B and Coronary Heart Disease
Clinical trial update on Hyperapo B evaluating its effect on coronary heart disease; the NHLBI-sponsored study has completed.
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CLINICAL_TRIALS trial_result · 2015-12-29Clinical Trial Update: Safety Study of AEM-28 to Treat Refractory Hypercholesterolemia [Phase 1, Phase 2]
Phase 1/2 safety study of AEM-28 for refractory hypercholesterolemia completed; results were posted in 2015.
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CLINICAL_TRIALS trial_result · 2015-12-22Clinical Trial Update: Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study-2 [Phase 3]
Phase 3 trial update on reduction of LDL-C with PCSK9 inhibition in heterozygous familial hypercholesterolemia; results posted after complet…
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CLINICAL_TRIALS trial_result · 2015-12-21Clinical Trial Update: An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia [Phase 3]
An open-label extension of a Phase 3 trial assessing the long-term safety and efficacy of mipomersen in patients with familial hypercholeste…
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CLINICAL_TRIALS trial_result · 2015-11-06Clinical Trial Update: Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With Heterozygous Familial Hypercholesterolemia (ODYSSEY HIGH FH) [Phase 3]
Phase 3 trial ODYSSEY HIGH FH evaluated alirocumab added to lipid-modifying therapy versus placebo in patients with heterozygous familial hy…