Ewing Sarcoma

CLINICAL_TRIALS trial_result · 2024-09-04

Clinical Trial Update: Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]

Phase 2 Pediatric MATCH trial evaluating samotolisib in pediatric patients with relapsed or refractory tumors harboring TSC or PI3K/mTOR mut…

CLINICAL_TRIALS trial_result · 2024-08-23

Clinical Trial Update: A Study of KC1036 in Adolescents With Advanced Ewing Sarcoma [Phase 2]

This is a Phase 2 study of KC1036 in adolescents with advanced Ewing Sarcoma. The trial is currently recruiting.

CLINICAL_TRIALS trial_result · 2024-07-17

Clinical Trial Update: Palbociclib + Ganitumab In Ewing Sarcoma [Phase 2]

Phase 2 trial of palbociclib plus ganitumab in Ewing sarcoma has been terminated with results posted in July 2024.

CLINICAL_TRIALS research · 2024-06-11

Clinical Trial Update: Risk Stratification Oriented Treatment of Pediatric Ewing Sarcoma: a Prospective Multicenter Cohort Study [NA]

This document provides an update on a prospective multicenter cohort study evaluating risk-stratified treatment approaches for pediatric Ewi…

CLINICAL_TRIALS trial_result · 2024-05-16

Clinical Trial Update: A Study of Surufatinib in Combination With Gemcitabine in Pediatric, Adolescent, and Young Adult Patients With Recurrent or Refractory Solid Tumors [Phase 1, Phase 2]

This completed Phase 1/2 study evaluated the safety and preliminary efficacy of combining surufatinib with gemcitabine in pediatric, adolesc…

CLINICAL_TRIALS trial_result · 2024-05-06

Clinical Trial Update: Study of Genistein in Pediatric Oncology Patients (UVA-Gen001) [Phase 2]

Phase 2 pediatric trial of Genistein for various cancers was terminated, with results posted.

CLINICAL_TRIALS trial_result · 2024-04-25

Clinical Trial Update: Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) [Phase 2]

A pediatric MATCH phase 2 trial assessed olaparib in children with relapsed or refractory advanced solid tumors or non-Hodgkin lymphoma carr…

CLINICAL_TRIALS trial_result · 2023-12-04

Clinical Trial Update: Safety, Tolerability, Efficacy and Pharmacokinetics of Copanlisib in Pediatric Patients [Phase 1, Phase 2]

Clinical trial update on Copanlisib in pediatric patients with relapsed or refractory solid tumors or lymphoma, including neuroblastoma, wit…

CLINICAL_TRIALS trial_result · 2023-11-07

Clinical Trial Update: SARC024: A Blanket Protocol to Study Oral Regorafenib in Patients With Selected Sarcoma Subtypes [Phase 2]

Phase 2 trial evaluating oral regorafenib across selected sarcoma subtypes has completed enrollment with results posted.

CLINICAL_TRIALS trial_result · 2023-10-27

Clinical Trial Update: Use of GnRHa During Chemotherapy for Fertility Protection [Phase 3]

Phase 3 trial investigating GnRHa during chemotherapy to protect fertility in cancer patients; currently recruiting.

CLINICAL_TRIALS trial_result · 2023-09-13

Clinical Trial Update: Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]

This Phase 2 Pediatric MATCH trial evaluated vemurafenib in children with BRAF V600-mutant relapsed or refractory advanced solid tumors, non…

CLINICAL_TRIALS trial_result · 2023-09-08

Clinical Trial Update: ADI-PEG 20 in Combination With Gemcitabine and Docetaxel for the Treatment of Soft Tissue Sarcoma, Osteosarcoma, Ewing's Sarcoma, and Small Cell Lung Cancer [Phase 2]

Phase 2 trial of ADI-PEG 20 in combination with gemcitabine and docetaxel for soft tissue sarcoma, osteosarcoma, Ewing's sarcoma, and small …

CLINICAL_TRIALS trial_result · 2023-08-14

Clinical Trial Update: Indo-cyanine Green (ICG) in Paediatric Oncology MIS [Phase 4]

Phase 4 trial update on using Indo-cyanine Green (ICG) in pediatric oncology, with completed status.

CLINICAL_TRIALS trial_result · 2023-08-03

Clinical Trial Update: Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor [Phase 3]

A Phase 3 trial comparing combination chemotherapy regimens in patients with Ewing's Sarcoma/PNET, completed.

CLINICAL_TRIALS trial_result · 2023-08-01

Clinical Trial Update: A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577) [Phase 1, Phase 2]

A rollover protocol update is described to allow continued access to the LSD1 inhibitor seclidemstat (SP-2577) in ongoing Phase 1/Phase 2 tr…

CLINICAL_TRIALS trial_result · 2023-05-16

Clinical Trial Update: Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]

Phase 2 Pediatric MATCH trial evaluating Ulixertinib for MAPK-pathway-mutant tumors in children, including advanced solid tumors, Non-Hodgki…

CLINICAL_TRIALS trial_result · 2023-04-26

Clinical Trial Update: A Trial For Participants With Ewing's Sarcoma Treated With Vigil in Combination With Irinotecan and Temozolomide [Phase 3]

A Phase 3 trial evaluating Vigil in combination with irinotecan and temozolomide for Ewing sarcoma has been terminated; results posted in 20…

CLINICAL_TRIALS trial_result · 2023-03-24

Clinical Trial Update: A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and Young Adults With Recurrent or Treatment-resistant Cancer [Phase 1, Phase 2]

A phase 1/2 trial evaluating bempegaldesleukin (BEMPEG) in combination with nivolumab in pediatric and young adult patients with recurrent o…

CLINICAL_TRIALS trial_result · 2023-01-10

Clinical Trial Update: Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas [Phase 1, Phase 2]

Phase 1/2 trial evaluating nivolumab with or without ipilimumab in younger patients with recurrent or refractory solid tumors or sarcomas; c…

CLINICAL_TRIALS trial_result · 2022-11-28

Clinical Trial Update: Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors [Phase 2]

A Phase 2 clinical trial evaluating cabozantinib-s-maleate in pediatric patients with recurrent, refractory, or newly diagnosed sarcomas, Wi…

CLINICAL_TRIALS trial_result · 2022-11-01

Clinical Trial Update: Irinotecan and Temozolomide for Ewing Sarcoma [Phase 2]

Phase 2 clinical trial update investigating irinotecan and temozolomide for Ewing sarcoma.

CLINICAL_TRIALS trial_result · 2022-09-19

Clinical Trial Update: Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma [Phase 3]

Phase 3 clinical trial update evaluating the efficacy of dose intensification in non-metastatic Ewing sarcoma has completed.

CLINICAL_TRIALS trial_result · 2022-09-19

Clinical Trial Update: Protocol for the Treatment of Metastatic Ewing Sarcoma [Phase 2]

Phase 2 protocol update for tackling metastatic Ewing sarcoma; trial status completed.

CLINICAL_TRIALS trial_result · 2022-07-22

Clinical Trial Update: A Two-part Phase IIb Trial of Vigil (Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) in Ewing's Sarcoma [Phase 2]

Phase IIb trial of Vigil, an autologous tumor cell immunotherapy, in Ewing's Sarcoma completed with posted results in 2022.

CLINICAL_TRIALS trial_result · 2022-07-01

Clinical Trial Update: Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma [Phase 3]

A Phase 3 trial evaluating whether adding ganitumab to standard chemotherapy improves outcomes in newly diagnosed metastatic Ewing sarcoma; …

Top drugs studied for this disease