Esophageal Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors [Phase 1]
Phase 1 clinical trial update for IDE892 evaluating monotherapy and combination in MTAP-deleted advanced solid tumors. The study is currentl…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Neoadjuvant Camrelizumab With Palbociclib for Resectable Esophageal Squamous Cell Carcinomas [Phase 1]
Phase 1 neoadjuvant trial investigating camrelizumab with palbociclib for resectable esophageal squamous cell carcinoma; the study is curren…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Camrelizumab, Chemotherapy and Ivarmacitinib in Patients With Resectable Esophageal Squamous Cell Carcinoma [Phase 2]
A Phase 2 trial investigating camrelizumab with chemotherapy and ivaramacitinib as neoadjuvant therapy for resectable esophageal squamous ce…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types [Phase 1]
IDEAYA Biosciences is conducting a Phase 1 study of IDE034 in adults with multiple locally advanced or metastatic solid tumors; the trial is…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06) [Phase 1, Phase 2]
Umbrella trial MK-3475-06E (KEYMAKER-U06) is evaluating pembrolizumab-based combination therapies for Esophageal Squamous Cell Carcinoma and…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Study of YL201 Versus Investigator's Choice of Chemotherapy in Participants With Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma After Failure of First-Line Therapy [Phase 3]
Phase 3 clinical trial comparing YL201 to investigator's choice chemotherapy in locally advanced or metastatic esophageal squamous cell carc…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors [Phase 1]
Phase 1 trial update on the safety of RAD301 in healthy volunteers and patients with pancreatic ductal adenocarcinoma or other solid tumors;…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Pilot Study of [68Ga]Ga-ABY-025 Imaging in Patients Undergoing Treatment With HER2-targeted Therapy [EARLY_Phase 1]
This is a pilot early-phase imaging trial evaluating the HER2-targeted PET tracer [68Ga]Ga-ABY-025 in patients undergoing HER2-targeted ther…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Clinical Study on the Efficacy and Safety of Iparomlimab and Tuvonralimab Injection Combined With Nab-Paclitaxel in Neoadjuvant Therapy for Locally Advanced Resectable Esophageal Squamous Cell Carcinoma [Phase 2]
Phase 2 trial evaluating the combination of Iparomlimab and Tuvonralimab with nab-paclitaxel as neoadjuvant therapy for locally advanced res…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors [Phase 2]
A Phase 2 clinical trial evaluating Volrustomig as monotherapy or in combination with anti-cancer agents across multiple advanced/metastatic…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Neoadjuvant Therapy With Iparomlimab and Tuvonralimab, Lenvatinib and Chemotherapy in Resectable ESCC [Phase 2]
Phase 2 neoadjuvant trial of iparomlimab and tuvonralimab with lenvatinib and chemotherapy for resectable esophageal squamous cell carcinoma…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Phase 1/1b of RNDO-564 Single Agent or in Combination With Pembrolizumab in Bladder Cancer and Other Solid Tumors Associated With Nectin-4 [Phase 1]
Phase 1/1b trial evaluating RNDO-564 as a single agent or in combination with pembrolizumab in bladder cancer and nectin-4–associated solid …
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations [Phase 1, Phase 2]
Phase 1/2 trial of TER-2013 in solid tumors harboring AKT/PI3K/PTEN alterations is currently recruiting to assess safety and preliminary eff…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: KC1036 in Combination With PD-1 Antibody and Platinum-based Chemotherapy for First-line Advanced Esophageal Cancer [Phase 2]
Phase 2 clinical trial evaluating KC1036 in combination with a PD-1 antibody and platinum-based chemotherapy as first-line treatment for adv…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B) [Phase 1, Phase 2]
A Phase 1/Phase 2 trial in advanced esophageal squamous cell carcinoma is evaluating investigational agents with or without pembrolizumab in…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Tumor Microenvironment Changes After Neoadjuvant Chemo-Immunotherapy in Esophageal Squamous Cell Carcinoma
This clinical trial update describes a neoadjuvant chemo-immunotherapy approach and investigation of tumor microenvironment changes in esoph…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors [Phase 1, Phase 2]
Roche is conducting a dose-escalation Phase 1/2 trial of a PD-1/LAG-3 bispecific antibody in patients with advanced or metastatic solid tumo…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Efficacy and Safety of Neo-CRT Plus Serplulimab, Nimotuzumab in Patients With Locally Advanced Resectable ESCC [Phase 2]
Phase 2 trial assessing the efficacy and safety of Neo-CRT plus Serplulimab and Nimotuzumab in locally advanced resectable esophageal squamo…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: A Phase II Clinical Study of LBL-024 Combination Therapy in Patients With Advanced Solid Tumour[Substudy 03(ESCC)] [Phase 2]
Phase II study of LBL-024 in advanced solid tumours, including esophageal squamous cell carcinoma (substudy 03), is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Time-of-Day of Immunotherapy Infusion in Neoadjuvant Immunochemotherapy for Thoracic ESCC [Phase 2]
Phase 2 trial update evaluating whether the time of day for immunotherapy infusion influences outcomes in neoadjuvant immunochemotherapy for…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: A Phase III Study of First-line Anlotinib Combined With Benmelstobart in Patients With Advanced Esophageal Squamous Cell Carcinoma [Phase 3]
A Phase III trial is evaluating first-line therapy with anlotinib in combination with benmelstobart for advanced esophageal squamous cell ca…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating ALE.P02 as monotherapy in adults with CLDN1+ solid tumors, including squamous cell carcinomas of th…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Effectiveness and Performance of an Optical Biopsy Technology for Esophageal Cancer in Brazil and the United States [Phase 2]
A Phase 2 clinical study evaluating the effectiveness of an optical biopsy technology to detect esophageal squamous cell neoplasia, conducte…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Neoadjuvant Adebrelimab Plus Chemotherapy for Esophageal Cancer: A Clinical Study [Phase 2]
This update notes an ongoing Phase 2 clinical trial evaluating neoadjuvant adebrelimab combined with chemotherapy for esophageal squamous ce…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Study of Tislelizumab Combined With Chemoradiotherapy and Surgery for Unresectable Esophageal Squamous Cell Carcinoma [Phase 2]
Phase 2 study evaluating tislelizumab combined with chemoradiotherapy and surgery for unresectable esophageal squamous cell carcinoma, curre…