Esophageal Adenocarcinoma

CLINICAL_TRIALS trial_result · 2026-07-22

Clinical Trial Update: Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975) [Phase 3]

Phase 3 trial examining pembrolizumab plus chemoradiation versus placebo in esophageal cancer has completed.

CLINICAL_TRIALS trial_result · 2026-04-14

Clinical Trial Update: Cryotherapy for Malignant Dysphagia in Patients With Advanced Esophageal Cancer [NA]

This clinical trial update reports the completion of a study evaluating cryotherapy for malignant dysphagia in patients with advanced esopha…

CLINICAL_TRIALS trial_result · 2026-04-13

Clinical Trial Update: Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery [Phase 2, Phase 3]

A phase 2/3 trial of Nivolumab and Ipilimumab in esophageal and gastroesophageal junction adenocarcinoma undergoing surgery is currently sus…

CLINICAL_TRIALS trial_result · 2026-04-09

Clinical Trial Update: Clinical Study of Regorafenib and Nivolumab Plus Chemotherapy [Phase 1, Phase 2]

A Phase 1/Phase 2 clinical study of regorafenib and nivolumab plus chemotherapy for gastric and gastroesophageal junction adenocarcinoma (an…

CLINICAL_TRIALS trial_result · 2026-03-30

Clinical Trial Update: Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer [Phase 4]

Phase 4 trial evaluating genetic analysis-guided dosing of irinotecan within mFOLFIRINOX for locally advanced gastroesophageal and stomach c…

CLINICAL_TRIALS trial_result · 2026-03-19

Clinical Trial Update: Treatment of Cabotamig (ARB202) in Advanced Gastrointestinal Cancer Patients [Phase 1]

Phase 1 trial of Cabotamig (ARB202) in advanced gastrointestinal cancers has completed; no specific efficacy results are provided in the doc…

CLINICAL_TRIALS trial_result · 2026-02-02

Clinical Trial Update: A Study of PRT7732, an Oral SMARCA2 Degrader, in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation [Phase 1]

A Phase 1 study of PRT7732, an oral SMARCA2 degrader, in patients with SMARCA4-mutant advanced or metastatic solid tumors has been terminate…

CLINICAL_TRIALS trial_result · 2026-01-22

Clinical Trial Update: Combination of Chemotherapy and Adaptive MR-Guided Radiotherapy to Improve Outcomes in Patients With Esophageal Adenocarcinoma [Phase 1]

A Phase 1 trial assessing the combination of chemotherapy and adaptive MR-guided radiotherapy for esophageal adenocarcinoma and gastroesopha…

CLINICAL_TRIALS trial_result · 2026-01-09

Clinical Trial Update: Induction FLOT With CROSS CRT for Esophageal Cancer [Phase 2]

A Phase 2 clinical trial evaluating induction FLOT chemotherapy followed by CROSS chemoradiation for esophageal or gastroesophageal junction…

CLINICAL_TRIALS trial_result · 2025-12-30

Clinical Trial Update: Impact of Arterial Partial Pressure of Oxygen on Anastomotic Leakage After Esophagectomy

A completed clinical trial evaluating whether arterial partial pressure of oxygen influences the risk of anastomotic leakage after esophagec…

CLINICAL_TRIALS trial_result · 2025-12-24

Clinical Trial Update: Aceto-whitening in the Assessment of Gastrointestinal Neoplasia

Clinical trial update indicating completion of a study evaluating aceto-whitening for assessing neoplasia in Barrett's esophagus-related con…

CLINICAL_TRIALS trial_result · 2025-12-15

Clinical Trial Update: A Study of SGN-B6A in Chinese Participants With Advanced Solid Tumors [Phase 1]

A Phase 1 study of SGN-B6A in Chinese participants with advanced solid tumors has completed, reporting safety and preliminary activity acros…

CLINICAL_TRIALS trial_result · 2025-11-05

Clinical Trial Update: A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer [Phase 2]

Phase II trial evaluating the effect of itraconazole on pathologic complete response rates in resectable esophageal cancer is currently recr…

CLINICAL_TRIALS trial_result · 2025-10-22

Clinical Trial Update: Survey Study on Barrett's Esophagus Screening

A completed survey study from the University of Colorado, Denver, evaluated screening for Barrett's esophagus in individuals with gastroesop…

CLINICAL_TRIALS trial_result · 2025-10-03

Clinical Trial Update: Endoscopic Radiofrequency Ablation Versus Hybrid Argon Plasma Coagulation in the Treatment of Barrett's Esophagus [NA]

A completed clinical trial comparing endoscopic radiofrequency ablation with hybrid argon plasma coagulation for Barrett's esophagus.

CLINICAL_TRIALS trial_result · 2025-09-09

Clinical Trial Update: Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers [Phase 2]

Phase 2 trial evaluating tucatinib plus trastuzumab with oxaliplatin-based chemotherapy or pembrolizumab-containing regimens for HER2-positi…

CLINICAL_TRIALS trial_result · 2025-09-05

Clinical Trial Update: Durvalumab, an Anti-PDLI Antibody, and Tremelimumab, an Anti-CTLA4 Antibody, and Chemoradiation Before Surgery for Esophageal Cancer [Phase 1, Phase 2]

A phase 1/2 trial is evaluating durvalumab and tremelimumab with chemoradiation before surgery for esophageal and gastroesophageal junction …

CLINICAL_TRIALS trial_result · 2025-07-01

Clinical Trial Update: A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203) [Phase 2]

This is a Phase 2 master protocol evaluating SAR444245 in combination with other anticancer therapies for several gastrointestinal cancers; …

CLINICAL_TRIALS trial_result · 2025-06-27

Clinical Trial Update: CLUE: CLinical Utility Study of EsoGuard [NA]

The CLUE study evaluating the clinical utility of EsoGuard for Barrett's esophagus and related conditions has completed.

CLINICAL_TRIALS trial_result · 2025-06-08

Clinical Trial Update: Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers [Phase 1]

Phase 1 trial updating on the addition of Adavosertib to radiation therapy in patients with incurable esophageal and gastroesophageal juncti…

CLINICAL_TRIALS trial_result · 2025-05-29

Clinical Trial Update: Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery [Phase 1]

Phase 1 trial evaluating the addition of Telomelysin to chemoradiation for patients with advanced esophageal or gastroesophageal junction ad…

CLINICAL_TRIALS trial_result · 2025-05-11

Clinical Trial Update: The Microbiome, Bile Acids, and Notch in Barrett's Esophagus (BE)

This update notes the completion of a clinical trial investigating the roles of the microbiome, bile acids, and Notch signaling in Barrett's…

CLINICAL_TRIALS trial_result · 2025-03-31

Clinical Trial Update: A Study of Chemoradiation Associated with Nimotuzumab As the Treatment of Locally Advanced Esophageal Cancer [Phase 2, Phase 3]

A completed Phase 2/3 study evaluating nimotuzumab in combination with chemoradiation for locally advanced esophageal cancer.

CLINICAL_TRIALS trial_result · 2025-03-27

Clinical Trial Update: OPPOSITE: Outcome Prediction of Systemic Treatment in Esophagogastric Carcinoma [NA]

Clinical trial OPPOSITE, studying outcome prediction of systemic treatment in esophagogastric carcinoma, has completed. The sponsor is Unive…

CLINICAL_TRIALS trial_result · 2025-03-21

Clinical Trial Update: Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors [Phase 2]

Phase 2 study evaluating the efficacy of tislelizumab and spartalizumab across multiple cancers with PD-1 high mRNA expression; the trial is…

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