Esophageal Adenocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Observational Study of Patients Treated With Nivolumab and Chemotherapy for Advanced or Metastatic Esophageal, Gastroesophageal or Gastric Cancer in France
An observational study in France evaluating outcomes for patients with advanced gastric and esophageal cancers treated with nivolumab in com…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors [Phase 1]
Phase 1 clinical trial update for IDE892 evaluating monotherapy and combination in MTAP-deleted advanced solid tumors. The study is currentl…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204) [Phase 2, Phase 3]
A Phase 2/3 clinical trial (ROSETTA Gastric-204) is evaluating Pumitamig plus chemotherapy versus Nivolumab plus chemotherapy as first-line …
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma [Phase 2]
Phase 2 clinical trial evaluating the adverse events, efficacy, and optimal dose of ABBV-400 in combination with fluorouracil, leucovorin, a…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Trans-Oral Sampling as an Alternative Surveillance of Barrett's Esophagus Pilot
This clinical trial investigates trans-oral sampling as an alternative, non-invasive surveillance method for Barrett's esophagus and potenti…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body [Phase 3]
A Phase 3 trial is evaluating whether adding radiotherapy to standard chemotherapy improves outcomes for patients with metastatic esophageal…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants With Advanced or Metastatic Solid Tumors With KRAS Mutations or Amplification [Phase 1]
BeiGene is conducting a first-in-human Phase 1 study of BGB-53038, a pan-KRAS inhibitor, as a monotherapy or in combination, in participants…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: The Effect of Ablation Therapy on Barrett's Esophagus
A Mayo Clinic-sponsored clinical trial update evaluating the impact of ablation therapy on Barrett's esophagus and esophageal adenocarcinoma…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer [NA]
This clinical trial aims to optimize a risk model to predict cancer recurrence in Barrett's esophagus patients and to study the impact of ri…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors [Phase 1]
Phase 1 trial evaluating TJ033721 (Givastomig) in adults with advanced or metastatic solid tumors; the study is currently recruiting and inc…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels [Phase 2]
Phase 2 Yale-sponsored trial evaluating adding sequential cytoreductive intervention to standard-of-care therapy for metastatic foregut aden…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2) [Phase 2]
Phase 2 clinical trial update on Givastomig combined with nivolumab and chemotherapy for CLDN18.2-positive metastatic gastric cancer; the st…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 study of AZD5863 in adults with advanced or metastatic solid tumors is currently recruiting, including gastric cancer, gastroeso…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk Model Based on Biomarkers and New Technologies to Better Predict the Development of Cancer [NA]
A clinical trial in Antwerp is recruiting Barrett's Esophagus patients to evaluate quality of life and fear of cancer, and to develop a risk…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Oxaliplatin and Liposomal Irinotecan (Plus Trastuzumab for HER2-positive Disease) in Advanced Esophageal and Gastric Adenocarcinoma [Phase 2]
A Phase 2 clinical trial evaluating oxaliplatin and liposomal irinotecan with trastuzumab for HER2-positive disease in advanced esophageal a…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors [Phase 1]
Phase 1 study update for NRM-823 in locally advanced or metastatic refractory solid tumors, currently recruiting. The trial lists head and n…
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer [Phase 1]
A Phase 1 clinical trial update describing mesothelin-targeted CAR T-cell therapy in esophagogastric and mesothelin-expressing tumors, curre…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Abemaciclib Plus Ramucirumab for Esophageal/Gastroesophageal Junction Ca [Phase 1, Phase 2]
An ongoing Phase 1/2 study of abemaciclib plus ramucirumab for metastatic esophageal adenocarcinoma and metastatic gastroesophageal junction…
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: Phase I/II Study of Perioperative Chemotherapy Plus Immunotherapy Followed by Surgery in Localized Esophageal and Gastroesophageal Adenocarcinoma [Phase 2]
A Phase 2 study from MD Anderson evaluating perioperative chemotherapy plus immunotherapy followed by surgery for localized esophageal adeno…
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CLINICAL_TRIALS research · 2026-02-02Clinical Trial Update: Will a Pre-therapy Exercise Intervention Improve the Outcomes of Patients With Advanced Oesophageal Cancer? [NA]
A University of Surrey trial is exploring whether a pre-therapy exercise program can improve outcomes for patients with advanced esophageal …
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CLINICAL_TRIALS research · 2026-01-30Clinical Trial Update: ProofPrincip IntraTu TCells SinglDoseImmunCheckpoinInhib Gastro-Esophage Adenocarcinoma w/ARID1a Mu [EARLY_Phase 1]
Early-phase trial update on ProofPrincip intra-tumoral T cells with a single-dose checkpoint inhibitor for gastroesophageal adenocarcinoma w…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Registry Platform Gastric/Esophageal Cancer (SAPHIR)
This Clinical Trial Update reports an ongoing registry platform trial SAPHIR addressing gastric and esophageal cancers, currently recruiting…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: A Study of KK2269 in Adult Participants With Solid Tumors [Phase 1]
Phase 1 study update for KK2269 in adults with solid tumors; the trial is currently recruiting. Indications include gastric adenocarcinoma, …
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma [NA]
A Mayo Clinic-sponsored clinical trial is evaluating minimally invasive molecular methods for diagnosing Barrett's esophagus and esophageal …
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal Malignancies [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating cabozantinib plus durvalumab with or without tremelimumab in patients with gastroesophageal cancer and o…