Ebola Virus Disease
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CLINICAL_TRIALS trial_result · 2025-02-24Clinical Trial Update: Tolerance and Activity Evaluation of High Doses of Favipiravir Against Ebola Virus in the Semen [Phase 2]
A Phase 2 trial evaluated tolerability and antiviral activity of high-dose Favipiravir in semen of Ebola virus survivors; the study was term…
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: A Study of a 2-dose Ebola Vaccine Regimen of Ad26.ZEBOV Followed by MVA-BN-Filo in Healthy Pregnant Women [Phase 3]
A Phase 3 trial evaluating a two-dose Ebola vaccine regimen (Ad26.ZEBOV prime followed by MVA-BN-Filo boost) in healthy pregnant women has c…
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FDA approval · 2024-12-26FDA Approved: EBANGA — Supplemental Application (Emergent Manufacturing Operations Baltimore, LLC)
FDA approved a supplemental application to authorize manufacturing operations for EBANGA (ansuvimab) by Emergent Manufacturing Operations Ba…
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CLINICAL_TRIALS research · 2024-12-17Clinical Trial Update: Open-Label Expanded Access for Ebola-Infected Patients to Receive Human MAb Ansuvimab As Therapeutic or for HR PEP
This document reports an open-label expanded access program for Ebola virus disease patients to receive the monoclonal antibody ansuvimab (E…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: Safety and Immunogenicity of rVSVΔG-ZEBOV-GP Vaccination When Dosed Concurrently With mRNA COVID-19 Vaccine Booster Doses [Phase 4]
A Phase 4 clinical trial update evaluating the safety and immunogenicity of the Ebola vaccine Ervebo (rVSVΔG-ZEBOV-GP) when dosed concurrent…
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CLINICAL_TRIALS trial_result · 2024-01-02Clinical Trial Update: Long-term Safety Follow-up of Participants Exposed to the Candidate Ebola Vaccines Ad26.ZEBOV and/or MVA-BN-Filo [Phase 3]
Long-term safety follow-up results for Ebola vaccine candidates Ad26.ZEBOV and/or MVA-BN-Filo from a Phase 3 study have been posted after te…
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CLINICAL_TRIALS trial_result · 2023-12-13Clinical Trial Update: Ad26.ZEBOV Booster in Children Previously Vaccinated With Ad26.ZEBOV and MVA-BN-Filo (EBOVAC Booster Study) [Phase 2]
Phase 2 trial of Ad26.ZEBOV booster in children previously vaccinated shows completed status with posted results.
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CLINICAL_TRIALS trial_result · 2023-06-22Clinical Trial Update: A Study of 2-dose Vaccination Regimen of Ad26.ZEBOV and MVA-BN-Filo in Infants [Phase 2]
Results from a Phase 2 study of a two-dose Ad26.ZEBOV and MVA-BN-Filo vaccination regimen in infants have been completed and posted.
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CLINICAL_TRIALS trial_result · 2023-05-17Clinical Trial Update: A Study of 2-dose Vaccine Regimen Using 3 Consecutive Lots of Ad26.ZEBOV and MVA-BN-Filo in Adult Participants [Phase 3]
A Phase 3 study evaluating a two-dose vaccine regimen using Ad26.ZEBOV and MVA-BN-Filo in adults with Ebola has completed and results were p…
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CLINICAL_TRIALS trial_result · 2023-04-20Clinical Trial Update: Safety and Immunogenicity of the rVSVΔG-ZEBOV-GP Ebola Virus Vaccine Candidate in Children Living in Lambaréné, Gabon [Phase 1, Phase 2]
Phase 1/2 trial assessing safety and immunogenicity of the rVSVΔG-ZEBOV-GP Ebola vaccine candidate in children in Gabon has completed.
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CLINICAL_TRIALS trial_result · 2023-02-21Clinical Trial Update: Ad26.ZEBOV Booster in HIV+ Adults Previously Vaccinated With Ad26.ZEBOV/MVA-BN-Filo (EBOVAC HIV+ Booster Study) [Phase 2]
Phase 2 trial update on Ad26.ZEBOV booster given to HIV-positive adults previously vaccinated with Ad26.ZEBOV/MVA-BN-Filo; study completed.
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CLINICAL_TRIALS trial_result · 2023-01-04Clinical Trial Update: Study to Evaluate the Immunogenicity and Safety of a Heterologous Vaccine Regimen Against Ebola [Phase 2]
Phase 2 trial evaluating immunogenicity and safety of a heterologous vaccine regimen for Ebola Virus Disease has completed.
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CLINICAL_TRIALS trial_result · 2022-09-28Clinical Trial Update: Partnership for Research on Ebola VACcinations [Phase 2]
Phase 2 clinical trial results for an Ebola vaccine collaboration have been completed and results posted.
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CLINICAL_TRIALS trial_result · 2022-07-18Clinical Trial Update: Staged Phase 3 Study to Assess the Safety and Immunogenicity of Ebola Candidate Vaccines Ad26.ZEBOV and MVA-BN-Filo [Phase 3]
Phase 3 study assessing safety and immunogenicity of Ebola vaccine candidates Ad26.ZEBOV and MVA-BN-Filo completed; results posted in 2022.
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FDA approval · 2022-05-13FDA Approved: INMAZEB — Supplemental Application (Regeneron Pharmaceuticals, Inc.)
The FDA approved a supplemental application for INMAZEB, Regeneron's triple-monoclonal antibody therapy for Ebola virus disease.
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CLINICAL_TRIALS trial_result · 2022-03-07Clinical Trial Update: Safety, Tolerability and Immunogenicity Study of 3 Prime-boost Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo in Healthy Adults, Children and Human Immunodeficiency Virus Positive (HIV+) Adults [Phase 2]
Phase 2 safety, tolerability, and immunogenicity study of three prime-boost regimens for Ebola vaccines Ad26.ZEBOV/MVA-BN-Filo in healthy ad…
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CLINICAL_TRIALS trial_result · 2022-02-18Clinical Trial Update: Safety, Tolerability and Immunogenicity Study of 2-dose Heterologous Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo [Phase 2]
This Phase 2 trial evaluated safety, tolerability and immunogenicity of two-dose heterologous Ebola vaccine regimens using Ad26.ZEBOV/MVA-BN…
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FDA approval · 2021-12-07FDA Approved: EBANGA — Supplemental Application (Emergent Manufacturing Operations Baltimore, LLC)
FDA approved a supplemental application to approve Emergent Manufacturing Operations Baltimore, LLC's facility for producing EBANGA (ansuvim…
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CLINICAL_TRIALS trial_result · 2021-11-23Clinical Trial Update: Effectiveness and Safety of a Heterologous, Two-dose Ebola Vaccine in the DRC [Phase 3]
A Phase 3 trial update evaluating the effectiveness and safety of a heterologous two-dose Ebola vaccine in the Democratic Republic of the Co…
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CLINICAL_TRIALS trial_result · 2021-10-15Clinical Trial Update: Prophylaxis Vaccine Antibodies Ebola [Phase 2]
Phase 2 clinical trial update for a prophylaxis vaccine antibodies targeting Ebola Virus Disease.
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CLINICAL_TRIALS trial_result · 2021-09-08Clinical Trial Update: Investigational Therapeutics for the Treatment of People With Ebola Virus Disease [Phase 2, Phase 3]
Phase 2/3 clinical trial update for investigational therapeutics in Ebola virus disease; study completed with results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-06-02Clinical Trial Update: A Trial to Evaluate the Safety and Systems Biology Response of Ebolavirus Zaire Vaccine (ChAd3-EBO-Z) [Phase 1]
A Phase 1 trial evaluating the safety and systems biology response of the ChAd3-EBO-Z Ebola vaccine has completed, with results posted.
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CLINICAL_TRIALS trial_result · 2021-05-12Clinical Trial Update: ZEBOVAC (Ebola Vaccine Trial, Ad26.ZEBOV/MVA-BN-Filo) [Phase 2]
Phase 2 trial update for the Ebola vaccine ZEBOVAC (Ad26.ZEBOV/MVA-BN-Filo) has completed.
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CLINICAL_TRIALS trial_result · 2021-02-08Clinical Trial Update: A Study to Assess Safety, Tolerability, and Immunogenicity of Three Heterologus 2-dose Regimens of the Candidate Prophylactic Vaccines for Ebola in Healthy Adults [Phase 2]
Phase 2 trial assessing safety, tolerability, and immunogenicity of three heterologous two-dose regimens of Ebola prophylactic vaccines in h…
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CLINICAL_TRIALS research · 2020-08-25Clinical Trial Update: International Multicenter Study of the Immunogenicity of Medicinal Product GamEvac-Combi [Phase 4]
Phase 4 international multicenter trial evaluating immunogenicity of GamEvac-Combi (Ebola vaccine) completed.