Diffuse Large B-cell Lymphoma
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL) [Phase 3]
This document reports on a Phase 3 trial of epcoritamab versus investigator's choice chemotherapy in relapsed/refractory diffuse large B-cel…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Rituximab in Combination With Glofitamab and Polatuzumab Vedotin in Patients With Previously Untreated Aggressive B-cell Lymphoma Ineligible for R-CHOP [Phase 2]
Phase 2 trial evaluating rituximab with glofitamab and polatuzumab vedotin for previously untreated aggressive B-cell lymphoma ineligible fo…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Trial of the Safety and Efficacy of Epcoritamab in Japanese Subjects With Relapsed or Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (R/R B-NHL) [Phase 1, Phase 2]
Clinical trial update announcing a Phase 1/2 study of epcoritamab in Japanese patients with relapsed or refractory B-cell non-Hodgkin lympho…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL) [Phase 1, Phase 2]
Clinical trial update on a phase 1/2 study evaluating safety and efficacy of epcoritamab combinations in adults with diffuse large B-cell ly…
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: A Phase 1 Trial of OPB-111077 in Combination With Bendamustine and Rituximab in Patients With r/r DLBCL [Phase 1]
This document summarizes a completed Phase 1 trial evaluating OPB-111077 in combination with bendamustine and rituximab for relapsed or refr…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Safety and Efficacy of Epcoritamab With Gemcitabine, Dexamethasone, and Cisplatin (GDP) Salvage Chemotherapy in Relapsed Refractory Large B-cell Lymphoma [Phase 2]
A Phase 2 clinical trial update assessing safety and efficacy of epcoritamab combined with GDP salvage chemotherapy for relapsed/refractory …
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: MRD-Adapted Low-Dose Radiation Therapy During Frontline Chemoimmunotherapy for Diffuse Large B-Cell Lymphoma [NA]
A clinical trial evaluating MRD-adapted low-dose radiation therapy during frontline chemoimmunotherapy for diffuse large B-cell lymphoma is …
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Study of CAR-T Therapy in Older Patients
A clinical trial update describing a CAR-T therapy study enrolling older adults with B-cell lymphomas and multiple myeloma, currently recrui…
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CLINICAL_TRIALS withdrawal · 2026-04-07Clinical Trial Update: A Study of Epcoritamab With Lenalidomide and Tafasitamab in People With Diffuse Large B Cell Lymphoma [Phase 2]
A Phase 2 trial evaluating a triplet regimen of epcoritamab with lenalidomide and tafasitamab in Diffuse Large B-Cell Lymphoma has been with…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma [Phase 3]
A Phase III study comparing glofitamab plus gemcitabine and oxaliplatin versus rituximab plus gemcitabine and oxaliplatin in relapsed/refrac…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: A Study Comparing C Pola R-CHP+X With CR-CHOP in the Treatment of Previously Untreated DEL Under the Guidance of Genotyping [Phase 3]
Phase 3 trial comparing C Pola R-CHP+X versus CR-CHOP for previously untreated double-expressor diffuse large B-cell lymphoma under genotypi…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Tafasitamab and Lenalidomide as First Salvage Therapy for Residual Large B Cell Lym [Phase 2]
Phase 2 trial evaluating tafasitamab plus lenalidomide as first salvage therapy for residual large B-cell lymphoma is currently recruiting (…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Anti-CD30 biAb-AATC in Patients With Relapsed/Refractory CD30 Positive Hematopoietic Malignancies [Phase 1]
Phase 1 trial evaluating an anti-CD30 bispecific antibody (AATC) in relapsed/refractory CD30-positive hematologic malignancies; currently re…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: CLIC-2201 for the Treatment of Relapsed/Refractory B Cell Malignancies [Phase 1]
A Phase 1 study of CLIC-2201 for relapsed/refractory B-cell malignancies is currently recruiting. The conditions covered include various B-c…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: An Observational Study of Glofitamab in Chinese Adult Participants With 2L Diffuse Large B-Cell Lymphoma
This entry describes an observational study of Glofitamab in Chinese adults with second-line Diffuse Large B-Cell Lymphoma and notes that th…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Ibrutinib, Rituximab, Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin Hydrochloride in Treating Patients With HIV-Positive Stage II-IV Diffuse Large B-Cell Lymphomas [Phase 1]
Phase 1 trial evaluating the safety and tolerability of a multi-agent regimen including ibrutinib, rituximab, etoposide, prednisone, vincris…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Study of Allo-QuadCAR01-T, an Allogeneic CAR-T Targeting CD19/CD20, in Patients With Relapsed or Refractory B-Cell Malignancies [Phase 1, Phase 2]
Clinical trial update for Allo-QuadCAR01-T, an allogeneic CD19/CD20 CAR-T, in relapsed or refractory B-cell malignancies, currently recruiti…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Chidamide Maintenance for MRD-Positive Double-Expressor DLBCL in First Complete Remission [Phase 2]
Phase 2 clinical trial evaluating chidamide maintenance in MRD-positive double-expressor diffuse large B-cell lymphoma patients in first com…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Dosimetry and Biodistribution of [18F]-Fludarabine in Lymphoid Malignancies [Phase 1]
Phase 1 dosimetry and biodistribution study of the radiotracer [18F]-Fludarabine in untreated lymphoid malignancies, including chronic lymph…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Tazemetostat and Venetoclax in Relapsed/Refractory Non-Hodgkin Lymphoma [Phase 1]
Phase 1 clinical trial of tazemetostat plus venetoclax for relapsed/refractory non-Hodgkin lymphoma has been terminated, including diffuse l…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: R-CDOP Combined With Intrathecal Methotrexate for DLBCL Patients With High-risk of CNS Relapse [Phase 2]
Phase 2 trial from Fudan University evaluating R-CDOP with intrathecal methotrexate for diffuse large B-cell lymphoma patients at high risk …
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: A Study Evaluating the Safety and Efficacy of Glofitamab + Gemcitabine + Oxaliplatin in U.S. Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma [Phase 1]
This Phase 1 clinical trial update describes evaluating the safety and preliminary efficacy of a triplet regimen (glofitamab, gemcitabine, a…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients [Phase 3]
Phase 3 clinical trial update evaluating Tafasitamab plus Lenalidomide in combination with R-CHOP versus R-CHOP alone for newly diagnosed hi…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers [Phase 1]
Phase 1 clinical trial update for PF-08046032 in people with advanced cancers; the study is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Low Dose Epcoritamab Plus GemOx in R/R DLBCL [Phase 2]
A Phase 2 clinical trial is testing low-dose epcoritamab in combination with GemOx (gemcitabine and oxaliplatin) for relapsed/refractory dif…