Diffuse Large B-cell Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma [Phase 3]
A Phase 3 trial is evaluating axicabtagene ciloleucel versus standard-of-care therapy as first-line treatment for high-risk diffuse large B-…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Geriatric-guided Care Versus Conventional Care in Elderly Unfit/Frail Patients With Diffuse Large B-cell Lymphoma in First Line Treatment [NA]
Clinical trial comparing geriatric-guided care versus conventional care in elderly unfit/frail patients with Diffuse Large B-Cell Lymphoma a…
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CLINICAL_TRIALS other · 2026-04-14Clinical Trial Update: Testing CC-486 (Oral Azacitidine) Plus the Standard Drug Therapy in Patients 75 Years or Older With Newly Diagnosed Diffuse Large B Cell Lymphoma [Phase 2, Phase 3]
A phase 2/3 trial evaluating CC-486 (oral azacitidine) added to standard therapy for patients aged 75 and older with newly diagnosed diffuse…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies [Phase 1]
NX-5948 is being studied in a Phase 1 trial for adults with relapsed/refractory B-cell malignancies; the study is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma [Phase 1]
Phase 1 clinical trial evaluating CAR-T cell therapy for HIV-infected individuals with AIDS-related and other B-cell non-Hodgkin lymphomas; …
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: SynKIR-310 for Relapsed/Refractory B-NHL [Phase 1]
Phase 1 trial update for SynKIR-310 in relapsed/refractory B-cell non-Hodgkin lymphoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Constitutive IL7R (C7R) Modified Banked Allogeneic CD30.CAR EBVSTS for CD30-Positive Lymphomas [Phase 1]
Phase 1 clinical trial update for constitutive IL7R (C7R) modified banked allogeneic CD30.CAR EBVSTs in CD30-positive lymphomas, currently r…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma [Phase 1, Phase 2]
This document provides a status update on a Phase 1/2 clinical trial evaluating JNJ-90014496 in participants with B-cell non-Hodgkin lymphom…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Combination of Nivolumab and ASTX727 for Relapsed or Refractory B-Cell Lymphoma [Phase 1]
A Phase 1 clinical trial is evaluating the combination of nivolumab with ASTX727 (decitabine/cedazuridine) in relapsed or refractory B-cell …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma [Phase 1]
A Phase 1 trial is evaluating the addition of the immunotherapy atezolizumab to a Rituximab-Gemcitabine-Oxaliplatin regimen for relapsed/ref…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies [Phase 1, Phase 2]
AstraZeneca is evaluating AZD0486 as a monotherapy or in combination with other anticancer agents for mature B-cell malignancies in Phase 1/…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Long-term Extension Study of PCI-32765 (Ibrutinib) [Phase 3]
Phase 3 long-term extension study of ibrutinib (PCI-32765) in chronic lymphocytic leukemia/small lymphocytic lymphoma and other B-cell malig…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01) [Phase 1, Phase 2]
Substudy 01A of MK-9999-01A (LIGHTBEAM-U01) evaluates Zilovertamab Vedotin in pediatric and young adult participants with hematologic malign…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: KSV01 Injection for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma [Phase 1]
Phase 1 clinical trial update for KSV01 injection in relapsed/refractory diffuse large B-cell lymphoma (DLBCL) and non-Hodgkin lymphoma; tri…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Real World Practice With Academic Anti CD19 CAR-T Cell Therapy in Relapse/Refractory B-cell Lymphoma
This clinical trial explores real-world use of an academic anti-CD19 CAR-T cell therapy for relapse/refractory diffuse large B-cell lymphoma…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Addition of a New Anti-cancer Drug, Venetoclax, to Usual Chemotherapy for High Grade B-cell Lymphomas [Phase 2, Phase 3]
A Phase 2/Phase 3 trial is evaluating adding venetoclax to standard chemotherapy for high-grade B-cell lymphomas, including diffuse large B-…
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: Long-term Follow-up Study of Allogeneic Gamma Delta (γδ) CAR T Cells
This document provides a long-term follow-up update on allogeneic gamma delta CAR T cell therapy. The trial covers several B-cell lymphoma i…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: NT-I7 (Efineptakin Alfa), a Long-acting Human IL-7, Post-Axicabtagene Ciloleucel or Post-Lisocabtagene Maraleucel in Subjects With Relapsed/Refractory Large B-cell Lymphoma [Phase 1]
Phase 1 trial evaluating NT-I7 (efineptakin alfa), a long-acting IL-7, in patients with relapsed/refractory diffuse large B-cell lymphoma af…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008) [Phase 1, Phase 2]
This is a Phase 1/2 clinical study of MK-1045 for non-Hodgkin lymphoma, including follicular lymphoma and diffuse large B-cell lymphoma, wit…
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Phase III Study of Tucidinostat in Combination With R-CHOP in Patients With Newly Diagnosed Double-Expressor DLBCL [Phase 3]
A Phase 3 trial evaluating tucidinostat in combination with R-CHOP for newly diagnosed double-expressor diffuse large B-cell lymphoma has co…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Sub-study Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL) in China [Phase 3]
A Phase 3 sub-study comparing epcoritamab to investigator's choice chemotherapy in relapsed/refractory diffuse large B-cell lymphoma in Chin…
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Subcutaneous Epcoritamab With or Without Lenalidomide as First Line Therapy for Diffuse Large B-Cell Lymphoma [Phase 2]
A Phase 2 clinical trial update on subcutaneous epcoritamab, with or without lenalidomide, as first-line therapy for diffuse large B-cell ly…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma [Phase 1, Phase 2]
Genmab-sponsored first-in-human trial in relapsed/refractory B-cell lymphomas spans Phase 1/2 and is currently active/not recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Long-term Follow-up Study for Patients Treated With CLBR001 CAR-T [Phase 1]
This clinical trial update reports long-term follow-up results from a Phase 1 study of CLBR001 CAR-T cells in relapsed/refractory B-cell lym…
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma [Phase 3]
A Phase 3 study evaluating subcutaneously injected epcoritamab plus oral lenalidomide versus intravenous rituximab with gemcitabine and oxal…