Developmental and Epileptic Encephalopathy
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE) [Phase 3]
A Phase 3 clinical trial to evaluate LP352 for developmental and epileptic encephalopathy in children and adults is currently recruiting. Th…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: SLC6A1-NDD Prospective Longitudinal Natural History Study
This clinical trial update describes a prospective longitudinal natural history study of SLC6A1-related neurodevelopmental disorder and rela…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Genetic Developmental and Epileptic Encephalopathy Natural History Study for Clinical Trial Readiness
This clinical trial update describes an ongoing natural history study of genetic developmental and epileptic encephalopathy, including MEF2C…
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: Developmental and Epileptic Encephalopathies Diagnosed Via Long-read Genome Sequencing
A clinical trial evaluating long-read genome sequencing to diagnose developmental and epileptic encephalopathies in children; the study is n…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy [EARLY_Phase 1]
Status update on a Phase 1 trial evaluating phenylbutyrate for monogenic developmental and epileptic encephalopathies, including STXBP1-rela…
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CLINICAL_TRIALS research · 2026-01-05Clinical Trial Update: A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE) [Phase 3]
Phase 3 study LP352 for Developmental and Epileptic Encephalopathy is currently enrolling by invitation in children and adults.
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: A Clinical Trial for Participants With DEE to Assess Efficacy, Safety, Tolerability, and PK of Relutrigine [Phase 3]
A Phase 3 trial is recruiting to evaluate the efficacy, safety, tolerability, and pharmacokinetics of Relutrigine for Developmental and Epil…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy [Phase 2]
This report covers a long-term, open-label Phase 2 safety study of LP352 in developmental and epileptic encephalopathy, including Dravet and…
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CLINICAL_TRIALS trial_result · 2025-10-30Clinical Trial Update: Melatonin for the Treatment of DEE-SWAS [Phase 2]
Phase 2 clinical trial evaluating melatonin for treatment of electrical status epilepticus in sleep and related developmental epileptic ence…
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CLINICAL_TRIALS trial_result · 2025-10-01Clinical Trial Update: A Clinical Trial of CAP-002 Gene Therapy in Pediatric Patients With Syntaxin-Binding Protein 1 (STXBP1) Encephalopathy [Phase 1, Phase 2]
A clinical trial update indicates that the CAP-002 gene therapy trial in pediatric STXBP1-related encephalopathy (a developmental and epilep…
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CLINICAL_TRIALS research · 2025-06-29Clinical Trial Update: Developmental and Epileptic Encephalopathy of Genetic Etiology: Natural History Through Reuse of Clinical Data
This clinical trial update describes a natural history study of Developmental and Epileptic Encephalopathy of genetic etiology that will reu…
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CLINICAL_TRIALS research · 2025-03-04Clinical Trial Update: Home Ultra-long Term EEG Monitoring for Rare Epilepsies and Developmental and Epileptic Encephalopathies [NA]
Clinical trial update for a study evaluating home ultra-long term EEG monitoring for rare epilepsies and developmental and epileptic encepha…
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CLINICAL_TRIALS research · 2025-01-22Clinical Trial Update: Intermediate-Size Expanded Access Protocol (EAP) for LP352
Update on Longboard Pharmaceuticals' expanded access protocol for LP352, indicating availability for patients with Dravet syndrome, Lennox-G…
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CLINICAL_TRIALS trial_result · 2024-11-08Clinical Trial Update: Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies [Phase 1, Phase 2]
Clinical trial update indicates LP352 has completed Phase 1/2 studies in developmental and epileptic encephalopathies. The program covers Dr…
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CLINICAL_TRIALS trial_result · 2024-08-23Clinical Trial Update: XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy [Phase 3]
Phase 3 trial of XEN496 (ezogabine) in children with KCNQ2 developmental and epileptic encephalopathy was terminated with results posted.
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CLINICAL_TRIALS trial_result · 2020-01-10Clinical Trial Update: Study of TAK-935 as an Adjunctive Therapy in Participants With Developmental and/or Epileptic Encephalopathies [Phase 1, Phase 2]
A Phase 1/2 clinical trial of TAK-935 as an adjunctive therapy for developmental and/or epileptic encephalopathies has been completed with r…