Cushing Disease
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Long-Term Follow-Up of Survivors of Pediatric Cushing Disease
ClinicalTrials.gov entry describing a long-term follow-up study of pediatric survivors of Cushing disease, currently recruiting to assess ou…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: DDAVP for Pituitary Adenoma [NA]
A clinical trial is evaluating desmopressin (DDAVP) for Cushing's disease and pituitary adenoma, and the study is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
This clinical trial update notes that the NICHD study on pituitary tumors and related hypothalamic disorders is actively recruiting, coverin…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Cushing's Disease Complications
This entry notes that a clinical trial investigating complications of Cushing's disease has completed.
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Evaluation of Positron Emission Tomography (PET) With [18F]FET for the Detection of ACTH-Secreting Corticotroph Pituitary Neuroendocrine Tumors.
A clinical trial is evaluating PET imaging with the tracer [18F]FET to detect ACTH-secreting corticotroph pituitary neuroendocrine tumors in…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease [EARLY_Phase 1]
Mayo Clinic sponsors an early Phase 1 trial to evaluate FET PET/CT imaging to localize pituitary adenomas in Cushing's disease.
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: A Trial of Lu AG13909 in Adult Participants With Cushing's Disease [Phase 2]
A Phase 2 clinical trial evaluating Lu AG13909 in adults with Cushing's disease is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors
This document reports an update on a Mayo Clinic-sponsored clinical trial evaluating intraoperative contrast-enhanced ultrasound to identify…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: Use of [18F]FET PET-MRI to Improve Detection of Pituitary Adenomas in Cushing's Disease [NA]
A clinical trial is evaluating whether [18F]FET PET-MRI improves detection of pituitary adenomas in patients with Cushing's disease, with en…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Assessment of Persistent Cognitive Impairment After Cure of Cushing's Disease [NA]
This ClinicalTrials.gov update reports on a completed study assessing whether cognitive impairment persists after cure of Cushing's disease.
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms
This clinical trial evaluates the diagnostic performance of salivary cortisol measured by chemiluminescence to distinguish hypercorticism. I…
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FDA approval · 2025-11-04FDA Approved: ISTURISA — Supplemental Application (Recordati Rare Diseases, Inc.)
The FDA approved a supplemental application for Isturisa (osilodostat) submitted by Recordati Rare Diseases, Inc.
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CLINICAL_TRIALS research · 2025-10-23Clinical Trial Update: Collecting Information About Treatment Results for Patients With Cushing's Syndrome
A clinical trial is enrolling to collect information about treatment results for patients with Cushing's Syndrome and Cushing's Disease.
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: SPI-62 as a Treatment for Adrenocorticotropic Hormone-dependent Cushing's Syndrome [Phase 2]
Phase 2 study of SPI-62 in ACTH-dependent Cushing's syndrome (Cushing disease) has completed. The document lists Sparrow Pharmaceuticals as …
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Impact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's Disease [NA]
This clinical trial investigates the use of [11C]-Methionine PET/MRI to detect ACTH-secreting pituitary adenomas causing Cushing's disease, …
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease [Phase 2]
A multicenter Phase 2 trial is underway to evaluate Seliciclib (R-roscovitine) for Cushing disease and is currently recruiting.
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Fimepinostat, Combination HDAC and Pi3-kinase Inhibitor Tumor-Directed Therapy for Cushing Disease [Phase 2]
A Phase 2 clinical trial sponsored by UCLA is evaluating fimepinostat, a dual HDAC and PI3-kinase inhibitor, for Cushing disease and is curr…
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: Postoperative Thrombosis Prevention in Patients With CD [NA]
This entry provides an update on a clinical trial evaluating postoperative thrombosis prevention in patients with Cushing disease, with the …
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CLINICAL_TRIALS trial_result · 2025-06-19Clinical Trial Update: Open-label Treatment in Cushing's Syndrome [Phase 3]
A Phase 3 open-label trial for Cushing's syndrome and Cushing disease sponsored by Cortendo AB has completed, with results posted in June 20…
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FDA approval · 2025-04-15FDA Approved: ISTURISA — Supplemental Application (Recordati Rare Diseases, Inc.)
The FDA approved a supplemental application for ISTURISA (osilodrostat) filed by Recordati Rare Diseases, Inc., reflecting an approved updat…
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CLINICAL_TRIALS withdrawal · 2025-04-15Clinical Trial Update: Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing s Disease [Phase 2]
A Phase 2 clinical trial evaluating vorinostat for ACTH-producing pituitary adenomas in Cushing's disease has been withdrawn.
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the safety and pharmacokinetics of CRN04894 for Cushing's syndrome and related ACTH-dependent conditio…
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EMA approval · 2024-12-18EMA Authorised: Signifor (pasireotide) — Recordati Rare Diseases
The EMA authorised Signifor (pasireotide) for acromegaly and pituitary ACTH hypersecretion. Recordati Rare Diseases is the marketing authori…
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CLINICAL_TRIALS research · 2024-12-03Clinical Trial Update: Osilodrostat Therapy and 11C-methionine PET to Improve Corticotroph Adenoma Detection
This clinical trial evaluates osilodrostat therapy with 11C-methionine PET to improve corticotroph adenoma detection; the study is not yet r…
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CLINICAL_TRIALS trial_result · 2024-10-15Clinical Trial Update: Long Term Safety and Efficacy of Pasireotide s.c. in Patients With Cushing's Disease
This clinical trial update reports long-term safety and efficacy data for pasireotide subcutaneous in patients with Cushing's disease. The s…