Myelomonocytic Leukemia

• CLINICAL_TRIALS trial_result · 2019-05-06
  Clinical Trial Update: Dasatinib as Therapy for Myeloproliferative Disorders (MPDs) [Phase 2]

  Phase 2 trial evaluating dasatinib for myeloproliferative disorders; the study has completed and results were posted in 2019.

• CLINICAL_TRIALS trial_result · 2019-04-23
  Clinical Trial Update: Pilot Study of Leuprolide to Improve Immune Function After Allogeneic Bone Marrow Transplantation [Phase 2]

  Phase 2 pilot trial evaluating leuprolide to enhance immune function after allogeneic bone marrow transplantation has completed and results …

• CLINICAL_TRIALS trial_result · 2019-03-05
  Clinical Trial Update: A Study of E6201 for the Treatment of Advanced Hematologic Malignancies With FLT3 and/or Ras Mutations [Phase 1, Phase 2]

  Clinical trial update for E6201 in advanced hematologic malignancies with FLT3 and/or Ras mutations (Phase 1/2) shows terminated status; res…

• CLINICAL_TRIALS trial_result · 2019-02-08
  Clinical Trial Update: Phase I Dose Escalation Trial of Volasertib in Combination With Azacitidine in Patients With MDS or CMML [Phase 1]

  Phase I dose-escalation study of volasertib in combination with azacitidine in patients with myelodysplastic syndromes or chronic myelomonoc…

• CLINICAL_TRIALS trial_result · 2019-01-25
  Clinical Trial Update: Yttrium-90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk AML, ALL, or MDS [Phase 1]

  Phase 1 clinical trial evaluating Yttrium-90 anti-CD45 monoclonal antibody BC8 followed by donor stem cell transplant in patients with high-…

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• CLINICAL_TRIALS trial_result · 2018-12-06
  Clinical Trial Update: A Phase II Trial of SGI-110 in Patients With IPSS High and Int 2 Myelodysplastic Syndrome, Acute Myeloid Leukemia With 20-30% Marrow Blasts or Chronic Myelomonocytic Leukemia Type 2 Not Responding to Azacitidine or Decitabine After at Least 6 Courses or Relapsing After a Response [Phase 2]

  Phase II trial evaluating SGI-110 in patients with various high-risk myelodysplastic syndromes and related conditions not responding to prio…

• CLINICAL_TRIALS trial_result · 2018-10-24
  Clinical Trial Update: Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders [Phase 2]

  Phase 2 clinical trial evaluating fludarabine phosphate and total body irradiation followed by donor peripheral stem cell transplant in myel…

• CLINICAL_TRIALS trial_result · 2018-07-30
  Clinical Trial Update: Volasertib in Combination With Azacitidine in Japanese Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia [Phase 1]

  Phase 1 trial evaluating volasertib in combination with azacitidine in Japanese patients with myelodysplastic syndromes or chronic myelomono…

• CLINICAL_TRIALS trial_result · 2018-06-25
  Clinical Trial Update: Multicenter Study to Assess the Efficacy of Decitabine in the Treatment of Chronic Myelomonocytic Leukemia [Phase 2]

  A multicenter Phase 2 trial evaluating decitabine for chronic myelomonocytic leukemia has completed.

• CLINICAL_TRIALS trial_result · 2018-06-04
  Clinical Trial Update: Tipifarnib in Treating Patients With Chronic Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or Undifferentiated Myeloproliferative Disorders [Phase 1, Phase 2]

  The document notes the completion of a Phase 1/2 clinical trial evaluating tipifarnib in patients with chronic myeloid leukemia, chronic mye…

• CLINICAL_TRIALS trial_result · 2018-05-21
  Clinical Trial Update: Treo/Flu/TBI With Donor Stem Cell Transplant for Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia [Phase 2]

  Phase 2 clinical trial evaluating Treo/Flu/TBI with donor stem cell transplant for myelodysplastic syndrome or acute myeloid leukemia.

• CLINICAL_TRIALS trial_result · 2018-05-11
  Clinical Trial Update: Azacitidine and Arsenic Trioxide in Treating Patients With Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia [Phase 2]

  Phase 2 trial evaluating azacitidine plus arsenic trioxide in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia; t…

• CLINICAL_TRIALS trial_result · 2018-03-21
  Clinical Trial Update: Ipilimumab in Treating Patients With Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia [Phase 1]

  A Phase 1 study evaluating ipilimumab in patients with relapsed or refractory high-risk myelodysplastic syndrome or acute myeloid leukemia h…

• CLINICAL_TRIALS research · 2018-03-19
  Clinical Trial Update: Relevance of Peripheral Cells in the Pathophysiology of Chronic Myelomonocytic Leukemia (CMML)

  This document provides an update on the relevance of peripheral cells in the pathophysiology of Chronic Myelomonocytic Leukemia (CMML).

• CLINICAL_TRIALS trial_result · 2017-12-19
  Clinical Trial Update: A Study of HDC/IL-2 Treatment in Chronic Myelomonocytic Leukemia (CMML) [Phase 1, Phase 2]

  Clinical trial update for HDC/IL-2 treatment in chronic myelomonocytic leukemia (CMML) across Phase 1 and Phase 2.

• CLINICAL_TRIALS trial_result · 2017-12-06
  Clinical Trial Update: MEK Inhibitor MEK162, Idarubicin, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]

  A Phase 1 trial evaluating a MEK inhibitor (MEK162) in combination with idarubicin and cytarabine for adults with relapsed or refractory acu…

• CLINICAL_TRIALS trial_result · 2017-11-17
  Clinical Trial Update: Idarubicin, Cytarabine, and Pravastatin Sodium in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes [NA]

  This clinical trial evaluated a combination of idarubicin, cytarabine, and pravastatin sodium in adults with acute myeloid leukemia or myelo…

• CLINICAL_TRIALS trial_result · 2017-10-19
  Clinical Trial Update: Clofarabine, Cytarabine, and Filgrastim in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia, Advanced Myelodysplastic Syndrome, and/or Advanced Myeloproliferative Neoplasm [Phase 2]

  Phase 2 clinical trial evaluating the combination of Clofarabine, Cytarabine, and Filgrastim in adults with newly diagnosed acute myeloid le…

• CLINICAL_TRIALS trial_result · 2017-08-30
  Clinical Trial Update: Donor Peripheral Blood Stem Cell Transplant and Pretargeted Radioimmunotherapy in Treating Patients With High-Risk Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome [Phase 1]

  Phase 1 trial evaluating donor peripheral blood stem cell transplantation in combination with pretargeted radioimmunotherapy for patients wi…

• CLINICAL_TRIALS trial_result · 2017-08-22
  Clinical Trial Update: PK Study of Oral and IV Clofarabine in High Risk Myelodysplasia+Acute Leukemias [Phase 1]

  Phase 1 pharmacokinetic study of oral and intravenous clofarabine in high-risk myelodysplastic syndrome and acute leukemias; the trial has c…

• CLINICAL_TRIALS trial_result · 2017-07-02
  Clinical Trial Update: Imatinib (Gleevec(Registered Trademark)) to Treat Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia [Phase 2]

  A Phase 2 clinical trial evaluated imatinib (Gleevec) for chronic myelomonocytic leukemia, chronic myeloid leukemia, and atypical chronic my…

• CLINICAL_TRIALS trial_result · 2017-06-09
  Clinical Trial Update: Efficacy Study of Revlimid® and Low Dose Continuously Administered Melphalan to Treat High Risk MDS [Phase 2]

  Phase 2 efficacy study evaluating lenalidomide (Revlimid) with low-dose continuous melphalan for high-risk myelodysplastic syndromes, includ…

• CLINICAL_TRIALS trial_result · 2017-06-01
  Clinical Trial Update: Low-dose Oral Clofarabine for the Treatment of IPSS INT-1, INT-2 or HIGH Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia [Phase 1, Phase 2]

  This terminated Phase 1/2 trial evaluated low-dose oral clofarabine for IPSS INT-1/INT-2 or high-risk myelodysplastic syndromes and chronic …

• CLINICAL_TRIALS trial_result · 2017-05-24
  Clinical Trial Update: Azacitidine in Treating Patients With Relapsed Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant [Phase 2]

  Phase 2 trial of azacitidine in patients with relapsed myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia…

• CLINICAL_TRIALS withdrawal · 2017-05-08
  Clinical Trial Update: Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS) [Phase 1]

  A Phase 1 trial evaluating pacritinib in combination with low-dose decitabine for intermediate-high risk myelofibrosis and related myeloprol…