Myelomonocytic Leukemia

CLINICAL_TRIALS trial_result · 2025-05-23

Clinical Trial Update: DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia [Phase 1, Phase 2]

A phase 1/2 study of DS-1594b with or without azacitidine, venetoclax, or mini-HCVD in relapsed or refractory acute myeloid leukemia or acut…

CLINICAL_TRIALS research · 2025-05-18

Clinical Trial Update: A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML [Phase 1, Phase 2]

Clinical trial update showing CFI-400945 with or without azacitidine is being studied in acute myeloid leukemia, myelodysplastic syndromes, …

CLINICAL_TRIALS trial_result · 2025-04-22

Clinical Trial Update: Azacitidine, Venetoclax, and Trametinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Higher-Risk Myelodysplastic Syndrome [Phase 2]

Phase 2 trial evaluating a three-drug combination of azacitidine, venetoclax, and trametinib for relapsed or refractory acute myeloid leukem…

CLINICAL_TRIALS research · 2025-04-17

Clinical Trial Update: Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial [Phase 2]

Phase 2 trial evaluating fecal microbiota transplantation before allogeneic stem cell transplant; recruitment is ongoing across multiple hem…

CLINICAL_TRIALS research · 2025-04-15

Clinical Trial Update: Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT) [Phase 1]

Phase 1 clinical trial assessing a preventive therapy to reduce graft-versus-host disease in participants with hematologic malignancies unde…

CLINICAL_TRIALS research · 2025-04-04

Clinical Trial Update: Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant [EARLY_Phase 1]

An early-phase 1 clinical trial is evaluating hyperbaric oxygen therapy in combination with allogeneic peripheral blood stem cell transplant…

CLINICAL_TRIALS trial_result · 2025-04-02

Clinical Trial Update: Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders [Phase 1]

Phase 1 study of Veliparib with Topotecan, with or without Carboplatin, in relapsed or refractory acute leukemias, high-risk myelodysplastic…

CLINICAL_TRIALS research · 2025-03-28

Clinical Trial Update: Selinexor Combined With Azacitidine Therapy in High-Risk Myeloid Neoplasms Patients [Phase 2]

Phase 2 clinical trial evaluating selinexor in combination with azacitidine for high-risk myeloid neoplasms, currently not yet recruiting.

CLINICAL_TRIALS trial_result · 2025-03-20

Clinical Trial Update: Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies [Phase 2]

This Phase 2 trial investigates reduced-intensity chemotherapy and radiation therapy before donor stem cell transplantation for various hema…

CLINICAL_TRIALS research · 2025-03-20

Clinical Trial Update: A Study Comparing Treatment Preference Between Oral Decitabine/Cedazuridine and Azacitidine in Myelodysplastic Syndrome, Low-Blast Acute Myeloid Leukemia, or Chronic Myelomonocytic Leukemia [Phase 3]

A Phase 3 trial comparing oral decitabine/cedazuridine with azacitidine in myelodysplastic syndromes, acute myeloid leukemia with low blast …

CLINICAL_TRIALS trial_result · 2025-03-19

Clinical Trial Update: Study of FF-10501-01 in Patients With Relapsed or Refractory Hematological Malignancies [Phase 1, Phase 2]

Phase 1/2 study of FF-10501-01 in relapsed or refractory hematologic malignancies has completed, with results posted. The diseases studied i…

CLINICAL_TRIALS trial_result · 2025-03-05

Clinical Trial Update: LILRB4 STAR-T Cells in the Treatment of R/R AML/CMML [Phase 1]

A Phase 1 trial evaluating LILRB4 STAR-T Cells for relapsed/refractory acute myeloid leukemia and chronic myelomonocytic leukemia has comple…

CLINICAL_TRIALS trial_result · 2025-02-14

Clinical Trial Update: IO-202 as Monotherapy and IO-202 Plus Azacitidine ± Venetoclax in Patients in AML and CMML [Phase 1]

Phase 1 trial completion reporting IO-202 as a monotherapy and IO-202 in combination with azacitidine ± venetoclax in patients with acute my…

CLINICAL_TRIALS trial_result · 2025-02-13

Clinical Trial Update: Fostamatinib for the Treatment of Lower-risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia Who Have Failed Therapy With Hypomethylating Agents [Phase 1]

Phase 1 trial of fostamatinib for lower-risk myelodysplastic syndromes or chronic myelomonocytic leukemia after failure of hypomethylating a…

CLINICAL_TRIALS trial_result · 2025-01-23

Clinical Trial Update: SGI-110 in Participants With Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML) [Phase 1, Phase 2]

Clinical trial update reporting completion and posted results for SGI-110 (guadecitabine) in patients with myelodysplastic syndromes, chroni…

CLINICAL_TRIALS research · 2025-01-14

Clinical Trial Update: Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies [Phase 1]

This Phase 1 trial from Epigenetix, Inc. is evaluating a dual BET and CBP/p300 inhibitor across targeted advanced solid tumors and hematolog…

CLINICAL_TRIALS trial_result · 2025-01-06

Clinical Trial Update: Tagraxofusp (SL-401) in Participants With Chronic Myelomonocytic Leukemia (CMML) and Myelofibrosis (MF) [Phase 1, Phase 2]

A Phase 1/2 trial of Tagraxofusp (SL-401) in chronic myelomonocytic leukemia and myelofibrosis has completed with results posted (January 20…

CLINICAL_TRIALS research · 2024-12-20

Clinical Trial Update: GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG [Phase 3]

Phase 3 randomized trial comparing post-transplant cyclophosphamide versus anti-thymocyte globulin for graft-versus-host disease prophylaxis…

EMA approval · 2024-11-05

EMA Authorised: Vidaza (azacitidine) — Bristol-Myers Squibb Pharma EEIG

The EMA authorised Vidaza (azacitidine) in the EU for myelodysplastic syndromes and certain leukemias, including chronic myelomonocytic leuk…

CLINICAL_TRIALS trial_result · 2024-09-19

Clinical Trial Update: IDH2-Post-Allo-Trial for Patients with IDH2-mut Myeloid Neoplasms After Allo-SCT [Phase 2]

This is a Phase 2 trial evaluating IDH2-mutant myeloid neoplasms after allogeneic stem cell transplantation. The study status is completed.

CLINICAL_TRIALS trial_result · 2024-09-05

Clinical Trial Update: A Study of Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems [Phase 1]

Takeda announced results from a Phase 1 study of pevonedistat in people with blood cancers and solid tumors who also have kidney or liver im…

CLINICAL_TRIALS research · 2024-08-27

Clinical Trial Update: Myeloproliferative Neoplasms (MPNs) Patient Registry

An update on the Myeloproliferative Neoplasms (MPNs) Patient Registry sponsored by University Health Network in Toronto, currently recruitin…

CLINICAL_TRIALS trial_result · 2024-08-02

Clinical Trial Update: Effect of Food on Blood Levels of ASTX727 [Phase 1]

Phase 1 trial evaluating the impact of food on plasma levels of ASTX727 (decitabine/cedazuridine) in patients with myelodysplastic syndromes…

CLINICAL_TRIALS research · 2024-07-22

Clinical Trial Update: Intensive Conditioning withTHI/Bu/Flu/Ara-C in Allo-HSCT for Myeloid Malignancies With Extramedullary Involvement

This clinical trial is testing an intensive conditioning regimen consisting of Thiotepa, Busulfan, Fludarabine, and Cytarabine followed by a…

CLINICAL_TRIALS trial_result · 2024-07-17

Clinical Trial Update: Tipifarnib in Subjects With Chronic Myelomonocytic Leukemia, Other MDS/MPN, and Acute Myeloid Leukemia [Phase 2]

This Phase 2 trial evaluated tipifarnib in patients with chronic myelomonocytic leukemia and other myelodysplastic/myeloproliferative neopla…

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