Chronic Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2015-04-14Clinical Trial Update: Pegasys in Patients With Chronic Myeloid Leukemia (CML) [Phase 2]
A Phase 2 clinical trial evaluating Pegasys (pegylated interferon alfa-2a) in chronic myeloid leukemia was terminated, with results posted i…
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CLINICAL_TRIALS trial_result · 2015-04-03Clinical Trial Update: Sirolimus/Tacrolimus Combination After HLA Matched Related Peripheral Blood Stem Cell Transplants [Phase 2]
A Phase 2 clinical trial evaluating a sirolimus-tacrolimus combination following HLA-matched related peripheral blood stem cell transplantat…
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CLINICAL_TRIALS trial_result · 2015-03-20Clinical Trial Update: Phase I/II Study of Immune Therapy After Allograft in Patients With Myeloid Hemopathy [Phase 1, Phase 2]
An update on a Phase I/II trial evaluating an immune therapy given after allogeneic transplantation in patients with myeloid hematologic dis…
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CLINICAL_TRIALS trial_result · 2015-03-17Clinical Trial Update: Multicenter, PhaseⅣ, Open Label Trial of Nilotinib in Adult Patients Diagnosed Philadelphia Chromosome Positive(Ph+) Chronic Myeloid Leukemia in CP/AP Intolerant to Dasatinib [Phase 4]
This is a multicenter, Phase 4 open-label trial of nilotinib in adult patients with Philadelphia chromosome–positive chronic myeloid leukemi…
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CLINICAL_TRIALS trial_result · 2015-03-09Clinical Trial Update: Haploid Allogeneic Transplant Using the CliniMACS System [Phase 2]
A Phase 2 clinical trial evaluating haploid allogeneic transplantation using the CliniMACS System was terminated, with results posted in 201…
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CLINICAL_TRIALS trial_result · 2015-02-11Clinical Trial Update: A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies [Phase 1]
A Phase 1 pilot study evaluated co-infusing ex vivo expanded cord blood cells with an unmanipulated cord blood unit in patients undergoing c…
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CLINICAL_TRIALS trial_result · 2015-02-09Clinical Trial Update: Study to Evaluate Nilotinib in Chronic Myelogenous Leukemia (CML) Patients With SubOptimal Response [Phase 4]
This document reports the completion of a Phase 4 clinical trial evaluating nilotinib in chronic myeloid leukemia patients with suboptimal r…
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CLINICAL_TRIALS trial_result · 2015-01-30Clinical Trial Update: A Phase I Dose Escalation Combination Study in Patients With Chronic Myelogenous Leukemia (CML) and Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)(0457-009)(TERMINATED) [Phase 1]
A Phase I dose-escalation combination study in patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblast…
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CLINICAL_TRIALS trial_result · 2015-01-26Clinical Trial Update: A Phase II Study of MK0457 in Patients With T315I Mutant CML and Ph+All (0457-008) [Phase 2]
Phase II trial of MK0457 in T315I-mutant chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia was term…
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CLINICAL_TRIALS trial_result · 2015-01-15Clinical Trial Update: Homoharringtonine With Oral Gleevec in Chronic, Accelerated and Blast Phase Chronic Myeloid Leukemia (CML) [Phase 2]
A Phase 2 study evaluating the combination of homoharringtonine with oral imatinib (Gleevec) in chronic, accelerated-phase, and blast-phase …
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CLINICAL_TRIALS trial_result · 2015-01-06Clinical Trial Update: Stem Cell Transplantation for Patients With Cancers of the Blood [Phase 2]
Phase 2 trial update reporting results from stem cell transplantation for patients with blood cancers, including chronic myeloid leukemia, c…
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CLINICAL_TRIALS trial_result · 2014-12-15Clinical Trial Update: Efficacy and Safety of Imatinib Mesylate as First-line Treatment for the Patients With Chronic Phase of Chronic Myeloid Leukemia [Phase 4]
This document provides an update on a Phase 4 trial evaluating the efficacy and safety of imatinib mesylate as first-line treatment for pati…
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CLINICAL_TRIALS trial_result · 2014-12-03Clinical Trial Update: Intermittent Imatinib Treatment in Chronic Myeloid Leukemia and Philadelphia Chromosome (Ph+CML) Patients Who Achieved a Complete Cytogenetic Response (CCgR) on Standard Imatinib Therapy [Phase 2]
Phase 2 study assessing intermittent dosing of imatinib in patients with chronic myeloid leukemia who achieved complete cytogenetic response…
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FDA approval · 2014-11-25FDA Approved: BOSULIF — Supplemental Application (Pfizer Laboratories Div Pfizer Inc)
FDA approved a supplemental NDA for Bosulif (bosutinib) from Pfizer Laboratories Div Pfizer Inc, resulting in an approved change to the prod…
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CLINICAL_TRIALS trial_result · 2014-10-31Clinical Trial Update: A Study of Withdrawal of Immunosuppression and Donor Lymphocyte Infusions Following Allogeneic Transplant for Pediatric Hematologic Malignancies [Phase 2]
Phase 2 trial evaluating withdrawal of immunosuppression and donor lymphocyte infusions after allogeneic transplant in pediatric hematologic…
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EMA safety_alert · 2014-10-24European Medicines Agency recommends further measures to minimise risk of blood vessel blockage with Iclusig
EMA recommends additional measures to reduce the risk of blood vessel blockage with Iclusig (ponatinib), a cancer medicine, to improve patie…
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CLINICAL_TRIALS trial_result · 2014-10-24Clinical Trial Update: Bone Marrow Transplant Using a Reduced Intensity Regimen That is Given in Two Steps [Phase 1, Phase 2]
This Phase 1/2 study evaluated a two-step reduced-intensity conditioning regimen for bone marrow transplantation in patients with hematologi…
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CLINICAL_TRIALS trial_result · 2014-10-22Clinical Trial Update: Advanced Chronic Myelogenous Leukemia (CML) - Follow On: Study of BMS-354825 in Subjects With CML [Phase 3]
This is a Phase 3 clinical trial update for dasatinib (BMS-354825) in chronic myeloid leukemia; the study is completed and results were post…
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CLINICAL_TRIALS trial_result · 2014-10-21Clinical Trial Update: Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC) [Phase 3]
EPIC is a Phase 3 trial evaluating ponatinib as initial therapy in newly diagnosed chronic myeloid leukemia; the study was terminated, with …
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EMA safety_alert · 2014-10-10PRAC recommends further measures to minimise risk of blood vessel blockage with Iclusig
The EMA's Pharmacovigilance Risk Assessment Committee (PRAC) recommends additional measures to reduce the risk of blood vessel blockage with…
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CLINICAL_TRIALS trial_result · 2014-10-01Clinical Trial Update: A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I) [Phase 1]
A Phase I pharmacokinetic study comparing Imatinib Mesylate 400 mg (1 tablet) with Glivec 100 mg film-coated tablet (4 tablets) to assess PK…
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FDA approval · 2014-09-25FDA Approved: TASIGNA — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for Tasigna (nilotinib) submitted by Novartis Pharmaceuticals Corporation.
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CLINICAL_TRIALS trial_result · 2014-09-18Clinical Trial Update: STA-9090 for Treatment of AML, CML, MDS and Myeloproliferative Disorders [Phase 1]
Phase 1 clinical trial of ganetespib (STA-9090) for acute myeloid leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myelopr…
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FDA approval · 2014-09-04FDA Approved: BUSULFEX — Supplemental Application (Otsuka America Pharmaceutical, Inc.)
FDA approved a supplemental application for BUSULFEX (busulfan) submitted by Otsuka America Pharmaceutical, Inc.
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FDA label_change · 2014-08-15FDA Approved: ICLUSIG — Supplemental Application (Takeda Pharmaceuticals America, Inc.)
FDA approved a supplemental application to update the labeling for ICLUSIG (ponatinib hydrochloride) from Takeda Pharmaceuticals America, In…