Chronic Lymphocytic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2017-08-04Clinical Trial Update: Humanized CAR-T Therapy for Treatment of B Cell Malignancy [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating a humanized CAR-T cell therapy for chronic lymphocytic leukemia (a B-cell leukemia).
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CLINICAL_TRIALS trial_result · 2017-08-01Clinical Trial Update: Rituximab Maintenance Versus Observation After First-line Immunochemotherapy by FCR in Older Patients With Chronic Lymphocytic Leukemia [Phase 3]
Phase 3 trial evaluating Rituximab maintenance versus observation after first-line immunochemotherapy (FCR) in older patients with chronic l…
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CLINICAL_TRIALS trial_result · 2017-07-26Clinical Trial Update: A Study to Determine Final Geriatric Assessment in Haematology (GAH) Score as a Tool for Predicting Tolerance to Treatment in Elderly Patients (≥ 65 Years) With Haematologic Neoplasms
Completed clinical trial evaluating whether the final Geriatric Assessment in Haematology (GAH) score can predict tolerance to treatment in …
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CLINICAL_TRIALS trial_result · 2017-07-24Clinical Trial Update: Fludarabine and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Lymphocytic Leukemia or Waldenstrom's Macroglobulinemia [Phase 1, Phase 2]
This clinical trial update reports Phase 1/Phase 2 results for fludarabine and cyclophosphamide as conditioning therapy for donor stem cell …
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CLINICAL_TRIALS research · 2017-07-19Clinical Trial Update: Study of Safety,Efficacy and Pharmacokinetics of CT-1530 in Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's Macroglobulinemia [Phase 1, Phase 2]
Clinical trial update describing a Phase 1/Phase 2 study of CT-1530 in relapsed or refractory B-cell non-Hodgkin lymphoma, chronic lymphocyt…
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CLINICAL_TRIALS trial_result · 2017-07-13Clinical Trial Update: Study of Bendamustine/Rituxan Induction Chemotherapy With Revlimid Maintenance for Relapsed/Refractory CLL and SLL [Phase 2]
Phase 2 trial evaluating bendamustine/rituxan induction chemotherapy followed by Revlimid maintenance in relapsed/refractory chronic lymphoc…
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CLINICAL_TRIALS trial_result · 2017-07-11Clinical Trial Update: Lenalidomide With or Without Rituximab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia [Phase 2]
Phase 2 trial evaluating lenalidomide with or without rituximab in relapsed or refractory chronic lymphocytic leukemia has completed and res…
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: A Trial of the Safety of Escalating Doses of PRO131921 in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia [Phase 1, Phase 2]
A Phase 1/2 trial evaluating escalating doses of PRO131921 in relapsed or refractory chronic lymphocytic leukemia was terminated.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Lower But More Frequent Dose Rituximab to Treat Chronic Lymphocytic Leukemia [Phase 1]
A Phase 1 trial evaluated a lower, more frequent dosing regimen of rituximab for refractory chronic lymphocytic leukemia, with the study sta…
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CLINICAL_TRIALS trial_result · 2017-06-28Clinical Trial Update: Efficacy and Safety of Idelalisib in Combination With Obinutuzumab Compared to Chlorambucil in Combination With Obinutuzumab for Previously Untreated Chronic Lymphocytic Leukemia [Phase 3]
Phase 3 trial comparing idelalisib plus obinutuzumab versus chlorambucil plus obinutuzumab in previously untreated chronic lymphocytic leuke…
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CLINICAL_TRIALS trial_result · 2017-06-28Clinical Trial Update: Phase 1/1b Study of TRU-016 in Patients With Previously Treated CLL or Select Subtypes of Non-Hodgkin's Lymphoma [Phase 1]
The Phase 1/1b study of TRU-016 in patients with previously treated Chronic Lymphocytic Leukemia or select subtypes of Non-Hodgkin's Lymphom…
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CLINICAL_TRIALS trial_result · 2017-06-26Clinical Trial Update: Interaction Study of Ibrutinib and Cytochrome P450 (CYP) 3A Inhibitors in Participants With B-cell Malignancy [Phase 1]
Phase 1 interaction study assessing the effect of CYP3A inhibitors on ibrutinib exposure in patients with chronic lymphocytic leukemia; the …
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FDA approval · 2017-06-22FDA Approved: RITUXAN HYCELA — Original Application (Genentech, Inc.)
FDA approved RITUXAN HYCELA (rituximab and hyaluronidase) under an Original Application by Genentech. The subcutaneous formulation provides …
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FDA label_change · 2017-06-22FDA Approved: RITUXAN HYCELA — Supplemental Application (Genentech, Inc.)
FDA approved a supplemental application for Rituxan Hycela (rituximab and hyaluronidase) by Genentech, updating the labeling for this subcut…
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CLINICAL_TRIALS research · 2017-06-20Clinical Trial Update: A Study of Anti-CD19 CAR-T Cell Immunotherapy for Refractory /Relapsed B Cell Malignancies [Phase 1, Phase 2]
This clinical trial update reports on a Phase 1/Phase 2 study of an anti-CD19 CAR-T cell therapy for refractory/relapsed B-cell malignancies…
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CLINICAL_TRIALS trial_result · 2017-06-16Clinical Trial Update: A Study of Escalating Doses of Polatuzumab Vedotin in Participants With Relapsed or Refractory B-Cell Non-Hodgkins Lymphoma and Chronic Lymphocytic Leukemia and Polatuzumab Vedotin in Combination With Rituximab in Participants With Relapsed or Refractory B-Cell Non-Hodgkins Lymphoma [Phase 1]
This Phase 1 trial investigates escalating doses of polatuzumab vedotin in relapsed or refractory B-cell non-Hodgkin lymphoma and chronic ly…
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CLINICAL_TRIALS trial_result · 2017-06-14Clinical Trial Update: A Study of Rituximab (MabThera) in Combination With Chemotherapy in Participants With CD20-Positive B-Cell Chronic Lymphocytic Leukemia
This study evaluated Rituximab in combination with chemotherapy for CD20-positive B-cell chronic lymphocytic leukemia and has completed with…
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CLINICAL_TRIALS withdrawal · 2017-06-12Clinical Trial Update: Autologous ROR1R-CAR-T Cells for Chronic Lymphocytic Leukemia (CLL) [Phase 1]
A Phase 1 trial evaluating autologous ROR1R-CAR-T cells for chronic lymphocytic leukemia has been withdrawn.
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CLINICAL_TRIALS trial_result · 2017-06-06Clinical Trial Update: Rapid Infusion of Ofatumumab in Patients With Previously Treated Chronic Lymphocytic Leukemia [Phase 2]
Phase 2 clinical trial update evaluating rapid infusion of ofatumumab in patients with previously treated chronic lymphocytic leukemia; resu…
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CLINICAL_TRIALS trial_result · 2017-06-06Clinical Trial Update: Study Evaluating AMD3100 for Transplantation of Sibling Donor Stem Cells in Patients With Hematological Malignancies [Phase 1, Phase 2]
Phase 1/2 study evaluating plerixafor (AMD3100) as a stem cell mobilizer for transplantation from a sibling donor in various hematologic mal…
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CLINICAL_TRIALS trial_result · 2017-06-02Clinical Trial Update: Flavopiridol in Treating Patients With Previously Treated Chronic Lymphocytic Leukemia or Lymphocytic Lymphoma [Phase 1, Phase 2]
Clinical trial update reports completed Phase 1 and Phase 2 results for flavopiridol in previously treated chronic lymphocytic leukemia and …
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CLINICAL_TRIALS trial_result · 2017-05-31Clinical Trial Update: A Phase 2, Multicenter, Open-label Study of MEDI-551 in Adults With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) [Phase 2]
A Phase 2 open-label study evaluating MEDI-551 in adults with relapsed or refractory chronic lymphocytic leukemia; the trial has completed a…
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CLINICAL_TRIALS research · 2017-05-31Clinical Trial Update: An Observational Study Examining the Effect of Added MabThera Therapy in Patients With Untreated Chronic Lymphocytic Leukemia
This observational study evaluates adding MabThera (rituximab) therapy to initial treatment in patients with untreated chronic lymphocytic l…
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CLINICAL_TRIALS trial_result · 2017-05-24Clinical Trial Update: Yttrium Y 90 Ibritumomab Tiuxetan, Fludarabine, Radiation Therapy, and Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma [Phase 2]
Phase 2 clinical trial evaluating a multi-modality approach combining Yttrium-90 ibritumomab tiuxetan, fludarabine, radiation therapy, and d…
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CLINICAL_TRIALS trial_result · 2017-05-22Clinical Trial Update: Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma [Phase 2]
Phase 2 trial evaluating rituximab in patients undergoing donor peripheral blood stem cell transplantation for relapsed or refractory B-cell…