Cholestasis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-03Clinical Trial Update: Use of Omegaven Fish Oil Emulsion for Parenteral Nutrition Associated Liver Disease in Infants and Children [Phase 3]
Phase 3 trial evaluating Omegaven fish oil emulsion for parenteral nutrition-associated liver disease in infants and children has completed.
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: Linerixibat Long-term Safety, and Tolerability Study [Phase 3]
Phase 3 clinical trial update evaluating long-term safety and tolerability of linerixibat in cholestasis; the study is currently active but …
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CLINICAL_TRIALS trial_result · 2024-08-28Clinical Trial Update: FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)
This update reports on the FORCE trial evaluating FibroScan, a non-invasive liver fibrosis assessment tool, in pediatric cholestatic liver d…
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CLINICAL_TRIALS trial_result · 2024-04-24Clinical Trial Update: Open-Label Study of HTD1801 in Adult Subjects With Primary Biliary Cholangitis [Phase 2]
An open-label Phase 2 study of HTD1801 in adults with primary biliary cholangitis has completed with results posted.
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CLINICAL_TRIALS trial_result · 2024-03-07Clinical Trial Update: A4250, an IBAT Inhibitor in Pediatric Cholestasis [Phase 2]
Phase 2 clinical trial update for A4250 (IBAT inhibitor) in pediatric cholestasis has completed.
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CLINICAL_TRIALS trial_result · 2023-06-12Clinical Trial Update: Evaluate the Safety, Tolerability, and PK of EP547 in Healthy Subjects and Subjects With Cholestatic or Uremic Pruritus [Phase 1]
Phase 1 study evaluating safety, tolerability, and pharmacokinetics of EP547 in healthy subjects and patients with cholestatic or uremic pru…
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CLINICAL_TRIALS trial_result · 2022-05-10Clinical Trial Update: Efficacy of 24 Month of Bezafibrate in Primary Sclerosing Cholangitis With Persistent Cholestasis Despite Ursodeoxycholic Acid Therapy [Phase 3]
Phase 3 clinical trial evaluating 24 months of bezafibrate for primary sclerosing cholangitis with persistent cholestasis despite ursodeoxyc…
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CLINICAL_TRIALS trial_result · 2021-05-04Clinical Trial Update: Dose Response Study of GSK2330672 for the Treatment of Pruritus in Participants With Primary Biliary Cholangitis [Phase 2]
Phase 2 dose-response study for GSK2330672 in pruritus associated with primary biliary cholangitis has completed with results posted.
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CLINICAL_TRIALS trial_result · 2020-07-24Clinical Trial Update: Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Subjects [Phase 1]
Phase 1 study evaluating drug interaction between linerixibat and obeticholic acid in healthy subjects completed with results posted.
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CLINICAL_TRIALS trial_result · 2020-07-22Clinical Trial Update: Omegaven as Alternative Parenteral Fat Nutrition [Phase 3]
Phase 3 trial evaluating Omegaven as an alternative parenteral fat nutrition for cholestasis conditions; study completed with results posted…
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CLINICAL_TRIALS trial_result · 2020-06-26Clinical Trial Update: Pharmacokinetics (PKs) and Metabolism of Radiolabelled Linerixibat [Phase 1]
Phase 1 pharmacokinetics and metabolism study of radiolabelled linerixibat in cholestasis patients; results posted.
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CLINICAL_TRIALS trial_result · 2020-02-12Clinical Trial Update: A Safety and Efficacy Study to Determine if Giving Intravenous Fish Oil Helps Children With Liver Disease [Phase 2]
Phase 2 trial investigating intravenous fish oil in children with cholestasis was terminated; results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-01-23Clinical Trial Update: Standard Lipid Therapy vs IVFE Minimization for Prevention of PNALD [Phase 3]
A Phase 3 trial comparing standard lipid therapy to IV fat emulsion minimization for prevention of PNALD in cholestasis conditions has compl…
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CLINICAL_TRIALS trial_result · 2019-11-25Clinical Trial Update: Compassionate Use of Omegaven in Children [Phase 2, Phase 3]
A completed compassionate-use trial update for Omegaven in children with parenteral nutrition-associated cholestasis, with Phase 2 and Phase…
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CLINICAL_TRIALS trial_result · 2019-10-28Clinical Trial Update: Evaluation of Omegaven™ Parenteral Nutrition in Patients With Total Parenteral Nutrition (TPN)-Induced Cholestasis [Phase 2]
Phase 2 trial evaluating Omegaven for TPN-induced cholestasis (PNALD) has completed with results posted.
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CLINICAL_TRIALS trial_result · 2018-07-17Clinical Trial Update: Fibrates in Pediatric Cholestasis [Phase 2]
Phase 2 trial update on using fibrates for pediatric cholestasis; the study has completed.
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CLINICAL_TRIALS trial_result · 2018-01-09Clinical Trial Update: Preventing Cholestasis Using SMOFLipid® [Phase 4]
Phase 4 clinical trial update evaluating SMOFLipid for preventing cholestasis.
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CLINICAL_TRIALS trial_result · 2017-10-13Clinical Trial Update: Gabapentin to Treat Itch in Patients With Liver Disease [Phase 3]
This update reports the completion of a Phase 3 trial evaluating gabapentin to treat itch in patients with liver disease.
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CLINICAL_TRIALS trial_result · 2017-08-01Clinical Trial Update: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of Pruritus [Phase 2]
A Phase 2 study assessed safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of GSK2330672 in adults with primary …
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CLINICAL_TRIALS trial_result · 2017-05-31Clinical Trial Update: Effectiveness of Multicomponent Lipid Emulsion in Preterm Infants Requiring Parenteral Nutrition [Phase 3]
A Phase 3 trial evaluating the effectiveness of a multicomponent lipid emulsion in preterm infants requiring parenteral nutrition for choles…
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CLINICAL_TRIALS trial_result · 2017-04-17Clinical Trial Update: SMOFlipid to Lessen the Severity of Neonatal Cholestasis [Phase 1, Phase 2]
A University of Florida trial evaluating SMOFlipid to lessen the severity of neonatal cholestasis in Phase 1/2 has been terminated, with res…
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CLINICAL_TRIALS trial_result · 2016-11-09Clinical Trial Update: Dose-escalation Study of GSK2330672 in Japanese Healthy Male Volunteers [Phase 1]
Phase 1 dose-escalation study of GSK2330672 in Japanese healthy male volunteers for cholestasis has completed.
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CLINICAL_TRIALS trial_result · 2016-10-03Clinical Trial Update: Cholestasis in Extreme Low Birth Weight Infants (ELBW)
A clinical trial update indicates that a study on cholestasis in extreme low birth weight infants has completed.
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CLINICAL_TRIALS trial_result · 2016-06-16Clinical Trial Update: Low Dose Fat for the Prevention of Liver Disease in Babies With Gastrointestinal Disorders [Phase 4]
A Phase 4 trial evaluating low-dose fat to prevent liver disease in infants with cholestasis and related gastrointestinal disorders was term…
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CLINICAL_TRIALS trial_result · 2016-05-11Clinical Trial Update: Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones [NA]
A multicenter prospective evaluation of a new short-access cholangioscope for biliary duct strictures and gall stones has completed.