Cholestasis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-03Clinical Trial Update: Use of Omegaven Fish Oil Emulsion for Parenteral Nutrition Associated Liver Disease in Infants and Children [Phase 3]
Phase 3 trial evaluating Omegaven fish oil emulsion for parenteral nutrition-associated liver disease in infants and children has completed.
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: Linerixibat Long-term Safety, and Tolerability Study [Phase 3]
Phase 3 clinical trial update evaluating long-term safety and tolerability of linerixibat in cholestasis; the study is currently active but …
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: Osmotic Fragility in Red Blood Cells of Pediatric Patients With Cholestatic Liver Disease
Status update on a pediatric trial examining osmotic fragility in red blood cells for children with cholestasis; the study is currently acti…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Congenital Heart Diseases and Developmental Assessment in Cholestatic Infants Under Two Years
A clinical trial update from Assiut University on developmental assessment in cholestatic infants under two years with congenital heart dise…
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CLINICAL_TRIALS approval · 2025-08-19Clinical Trial Update: SMOF Lipid for Children With Parenteral Nutrition Induced Liver Injury
SMOF Lipid has received marketing approval for use in pediatric patients with parenteral nutrition–induced liver injury, associated with cho…
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EMA approval · 2025-07-11EMA Authorised: Bylvay (odevixibat) — Ipsen Pharma
EMA authorised Bylvay (odevixibat) from Ipsen Pharma for intrahepatic cholestasis as an orphan medicine with accelerated assessment.
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EMA approval · 2024-12-16EMA Authorised: Vedrop (tocofersolan) — Recordati Rare Diseases
The EMA has authorised Vedrop (tocofersolan) for the treatment of cholestasis-associated vitamin E deficiency under the marketing authorisat…
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FDA approval · 2024-11-21FDA Approved: CHOLESTYRAMINE — Original Application (Macleods Pharmaceuticals Limited)
FDA approved Macleods Pharmaceuticals' original application for cholestyramine, a bile acid sequestrant, for lowering cholesterol in hyperch…
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CLINICAL_TRIALS research · 2024-09-24Clinical Trial Update: PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals
A clinical trial from the University of Aarhus is evaluating PET/CT imaging with the tracer 11C-Csar to visualize cholestatic disorders in p…
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CLINICAL_TRIALS research · 2024-09-20Clinical Trial Update: PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Changes in the Hepatobiliary System in Patients With Primary Biliary Cholangitis Before and After Treatment.
An ongoing clinical trial update evaluating the 11C-Csar tracer, a bile acid analog, to image hepatobiliary changes in Primary Biliary Chola…
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CLINICAL_TRIALS trial_result · 2024-08-28Clinical Trial Update: FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)
This update reports on the FORCE trial evaluating FibroScan, a non-invasive liver fibrosis assessment tool, in pediatric cholestatic liver d…
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CLINICAL_TRIALS trial_result · 2024-04-24Clinical Trial Update: Open-Label Study of HTD1801 in Adult Subjects With Primary Biliary Cholangitis [Phase 2]
An open-label Phase 2 study of HTD1801 in adults with primary biliary cholangitis has completed with results posted.
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CLINICAL_TRIALS trial_result · 2024-03-07Clinical Trial Update: A4250, an IBAT Inhibitor in Pediatric Cholestasis [Phase 2]
Phase 2 clinical trial update for A4250 (IBAT inhibitor) in pediatric cholestasis has completed.
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CLINICAL_TRIALS trial_result · 2023-06-12Clinical Trial Update: Evaluate the Safety, Tolerability, and PK of EP547 in Healthy Subjects and Subjects With Cholestatic or Uremic Pruritus [Phase 1]
Phase 1 study evaluating safety, tolerability, and pharmacokinetics of EP547 in healthy subjects and patients with cholestatic or uremic pru…
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CLINICAL_TRIALS trial_result · 2022-05-10Clinical Trial Update: Efficacy of 24 Month of Bezafibrate in Primary Sclerosing Cholangitis With Persistent Cholestasis Despite Ursodeoxycholic Acid Therapy [Phase 3]
Phase 3 clinical trial evaluating 24 months of bezafibrate for primary sclerosing cholangitis with persistent cholestasis despite ursodeoxyc…
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EMA withdrawal · 2021-12-17EMA Application withdrawn: Livmarli (Maralixibat chloride) — FGK Representative Service GmbH
The EMA has withdrawn the application for Livmarli (maralixibat chloride) represented by FGK Representative Service GmbH.
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CLINICAL_TRIALS trial_result · 2021-05-04Clinical Trial Update: Dose Response Study of GSK2330672 for the Treatment of Pruritus in Participants With Primary Biliary Cholangitis [Phase 2]
Phase 2 dose-response study for GSK2330672 in pruritus associated with primary biliary cholangitis has completed with results posted.
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CLINICAL_TRIALS trial_result · 2020-07-24Clinical Trial Update: Linerixibat and Obeticholic Acid Drug Interaction Study in Healthy Subjects [Phase 1]
Phase 1 study evaluating drug interaction between linerixibat and obeticholic acid in healthy subjects completed with results posted.
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CLINICAL_TRIALS trial_result · 2020-07-22Clinical Trial Update: Omegaven as Alternative Parenteral Fat Nutrition [Phase 3]
Phase 3 trial evaluating Omegaven as an alternative parenteral fat nutrition for cholestasis conditions; study completed with results posted…
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CLINICAL_TRIALS trial_result · 2020-06-26Clinical Trial Update: Pharmacokinetics (PKs) and Metabolism of Radiolabelled Linerixibat [Phase 1]
Phase 1 pharmacokinetics and metabolism study of radiolabelled linerixibat in cholestasis patients; results posted.
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CLINICAL_TRIALS research · 2020-05-21Clinical Trial Update: Compassionate Use of an Intravenous Fish Oil Emulsion in the Treatment of Liver Injury in Infants [NA]
A completed clinical trial investigating compassionate use of an intravenous fish oil emulsion for liver injury in infants with cholestasis,…
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CLINICAL_TRIALS research · 2020-05-08Clinical Trial Update: Compassionate Use of Omegaven to Reverse Parenteral Nutrition Induced Cholestasis [NA]
A completed clinical trial investigating compassionate use of Omegaven to reverse parenteral nutrition–induced cholestasis.
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FDA approval · 2020-04-06FDA Approved: CHOLESTYRAMINE — Original Application (Ajanta Pharma USA Inc.)
FDA approved Ajanta Pharma USA's original application for a generic cholestyramine product.
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CLINICAL_TRIALS trial_result · 2020-02-12Clinical Trial Update: A Safety and Efficacy Study to Determine if Giving Intravenous Fish Oil Helps Children With Liver Disease [Phase 2]
Phase 2 trial investigating intravenous fish oil in children with cholestasis was terminated; results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-01-23Clinical Trial Update: Standard Lipid Therapy vs IVFE Minimization for Prevention of PNALD [Phase 3]
A Phase 3 trial comparing standard lipid therapy to IV fat emulsion minimization for prevention of PNALD in cholestasis conditions has compl…