Central Nervous System Neoplasms
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Cerebrospinal Fluid Biomarkers for Brain Tumors
A Mayo Clinic-sponsored clinical trial is investigating cerebrospinal fluid biomarkers for brain tumors and is currently recruiting particip…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors [Phase 1]
Phase 1 trial updating the investigation of HSV-1 G207 for children with recurrent or refractory cerebellar brain tumors; the study is curre…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases [Phase 2]
A Phase 2 clinical trial is evaluating single-fraction versus multifraction salvage spine stereotactic radiosurgery for previously irradiate…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Gadolinium and Ferumoxytol MRI in Diagnosing Patients With Abnormalities in the Central Nervous System [Phase 2]
Phase 2 clinical trial evaluating gadolinium-based contrast agents with ferumoxytol-enhanced MRI to diagnose abnormalities in the central ne…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma [Phase 1, Phase 2]
This entry reports a Phase 1/2 clinical trial evaluating CBL0137 for relapsed or refractory solid tumors, including central nervous system t…
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CLINICAL_TRIALS trial_result · 2026-02-05Clinical Trial Update: B7-H3.CD28Z.CART in CNS Neoplasms [Phase 1]
A Phase 1 clinical trial evaluating B7-H3.CD28Z.CART for central nervous system neoplasms is currently not yet recruiting.
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CLINICAL_TRIALS research · 2026-01-30Clinical Trial Update: A Clinical Prediction Model for Surgical Site Infection After Central Nervous System Tumor Surgery [NA]
This clinical trial is evaluating a clinical prediction model to predict surgical site infection after central nervous system tumor surgery.…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors [Phase 1]
Clinical trial update indicating that Loc3CAR (B7-H3-CAR T cells) delivery is in early-phase pediatric CNS tumor trials and currently recrui…
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CLINICAL_TRIALS withdrawal · 2026-01-08Clinical Trial Update: Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies [Phase 1]
A Phase 1 trial investigating fourth-ventricular administration of nivolumab with methotrexate or 5-azacytidine for recurrent medulloblastom…
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CLINICAL_TRIALS trial_result · 2025-12-02Clinical Trial Update: Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia [Phase 2]
Phase 2 trial evaluating larotrectinib for TRK fusion cancers across solid tumors and TRK fusion relapsed acute leukemia in pediatric patien…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Neoepitope-based Personalized DNA Vaccine Approach in Pediatric Patients With Recurrent Central Nervous System Tumors [Phase 1]
Phase 1 clinical trial evaluating a neoepitope-based personalized DNA vaccine in pediatric patients with recurrent central nervous system tu…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Neurobehavioral Functioning in Pediatric Brain Tumor Patients After Proton Beam Radiation Treatment
A completed clinical trial assessed neurobehavioral functioning in pediatric brain tumor patients following proton beam radiation therapy.
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CLINICAL_TRIALS trial_result · 2025-10-02Clinical Trial Update: Pharmacoscopy for Patients With Refractory Primary Brain Tumors [Phase 2]
Phase 2 clinical trial update for pharmacoscopy in patients with refractory primary brain tumors, currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: A Study of Metabolic Agents Following Brain Radiation
Completed clinical trial evaluating metabolic agents following brain radiation for central nervous system neoplasms. The snippet provides no…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: EPO906 Plus Radiation Therapy for the Treatment of Cancer Patients [Phase 1]
Phase 1 trial results for EPO906 in combination with radiation therapy in cancer patients, including central nervous system neoplasms and he…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: A Trial Using Velcade Plus Chemoradiation for Central Nervous System, Head and Neck, and Cervical Cancer Patients [Phase 1]
A Phase 1 trial evaluating Velcade (bortezomib) with chemoradiation in patients with brain/CNS neoplasms and head-and-neck/cervical cancers …
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CLINICAL_TRIALS withdrawal · 2025-02-04Clinical Trial Update: MRI Gadopiclenol Enhanced Imaging of CNS Tumors
ClinicalTrials.gov entry indicates the study evaluating gadopiclenol-enhanced MRI for central nervous system tumor imaging has been withdraw…
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CLINICAL_TRIALS research · 2025-01-24Clinical Trial Update: Circulating microRNAs as Disease Markers in Pediatric Cancers
A completed study evaluating circulating microRNAs as biomarkers for pediatric cancers, including leukemia, lymphoma, and central nervous sy…
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CLINICAL_TRIALS trial_result · 2024-11-21Clinical Trial Update: Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors [EARLY_Phase 1]
Completed EARLY Phase 1 clinical trial evaluating memantine to reduce cognitive impairment after radiation therapy in pediatric central nerv…
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CLINICAL_TRIALS trial_result · 2024-10-31Clinical Trial Update: RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant Solid and Central Nervous System Tumors [Phase 1]
This Phase 1 trial update indicates termination of the pediatric study evaluating RRx-001 with irinotecan and temozolomide for recurrent or …
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CLINICAL_TRIALS trial_result · 2024-09-27Clinical Trial Update: Blood Brain Barrier Differences in Patients with Brain Tumors Undergoing Surgery
This completed clinical trial examined differences in the blood-brain barrier in patients with brain tumors undergoing surgical resection.
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CLINICAL_TRIALS trial_result · 2024-05-10Clinical Trial Update: Cognitive Function After Treatment of Primary CNS Malignancy
A completed Mayo Clinic clinical trial evaluating cognitive function after treatment for primary central nervous system tumors.
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CLINICAL_TRIALS trial_result · 2024-01-02Clinical Trial Update: Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas [Phase 1]
A pediatric Phase 1 trial evaluating selinexor in children with recurrent or refractory solid tumors and high-grade gliomas has completed. R…
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CLINICAL_TRIALS trial_result · 2022-12-13Clinical Trial Update: Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
A Phase 2 pediatric MATCH trial evaluating selumetinib sulfate in relapsed or refractory advanced solid tumors, non-Hodgkin lymphoma, and hi…
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CLINICAL_TRIALS trial_result · 2022-09-23Clinical Trial Update: Pevonedistat, Irinotecan, and Temozolomide in Treating Patients With Recurrent or Refractory Solid Tumors or Lymphoma [Phase 1]
This Phase 1 study evaluated pevonedistat in combination with irinotecan and temozolomide in patients with recurrent or refractory solid tum…