Bipolar Depression
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CLINICAL_TRIALS trial_result · 2026-08-13Clinical Trial Results: A Trial of the Fatty Acid Amide Hydrolase Inhibitor Palmitoylethanolamide in Bipolar Depression [Phase 2]
Phase 2 trial results for a fatty acid amide hydrolase inhibitor (palmitoylethanolamide) in Bipolar Depression have been completed and resul…
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CLINICAL_TRIALS trial_result · 2026-04-06Clinical Trial Update: Low Dose IL-2 Therapy in Patients With a Depressive Episode in the Course of a Bipolar Disorder [Phase 2]
Phase 2 trial evaluating low-dose interleukin-2 therapy in Bipolar Depression has completed.
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CLINICAL_TRIALS trial_result · 2026-03-05Clinical Trial Update: Ketamine for Treatment-Resistant Bipolar Disorder [Phase 2]
A Phase 2 clinical trial evaluating ketamine for treatment-resistant bipolar disorder has completed.
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CLINICAL_TRIALS trial_result · 2026-03-05Clinical Trial Update: Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression [Phase 2]
A Phase 2 completed trial update evaluating maintenance ketamine infusions for treatment-resistant bipolar depression.
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression [Phase 2]
Phase 2 trial evaluating intravenous ketamine with functional MRI in treatment-resistant bipolar depression. The study has completed.
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CLINICAL_TRIALS trial_result · 2025-10-02Clinical Trial Update: A Trial of the Fatty Acid Amide Hydrolase Inhibitor Palmitoylethanolamide in Bipolar Depression [Phase 2]
Phase 2 trial of palmitoylethanolamide for bipolar depression has completed.
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: 8 Week Multi-site Study of MYDAYIS® for Bipolar Depression [Phase 2]
A Phase 2 multi-site study evaluating MYDAYIS for bipolar depression has completed.
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CLINICAL_TRIALS trial_result · 2025-06-27Clinical Trial Update: Ketamine Associated ACC GABA and Glutamate Change and Depression Remission: [EARLY_Phase 1]
This early-phase trial reports ketamine-associated changes in ACC GABA and glutamate and notes depression remission. The study targets major…
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CLINICAL_TRIALS trial_result · 2025-03-24Clinical Trial Update: Pilot Accelerated Theta Burst in Treatment-Resistant Bipolar Depression [NA]
This update reports the completion of a pilot accelerated theta burst stimulation trial in treatment-resistant bipolar depression and notes …
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CLINICAL_TRIALS trial_result · 2025-02-10Clinical Trial Update: Efficacy of rTMS in Bipolar Depression [NA]
Terminated clinical trial evaluating the efficacy of repetitive transcranial magnetic stimulation (rTMS) for bipolar depression has posted r…
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CLINICAL_TRIALS trial_result · 2024-12-12Clinical Trial Update: Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression [NA]
Long-term follow-up results from a terminated clinical trial evaluating deep brain stimulation for treatment-resistant depression have been …
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CLINICAL_TRIALS trial_result · 2024-11-04Clinical Trial Update: Efficacy of Convulsive Therapies for Bipolar Depression [NA]
A completed clinical trial evaluating the efficacy of convulsive therapies for bipolar depression, sponsored by the Centre for Addiction and…
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CLINICAL_TRIALS trial_result · 2024-04-09Clinical Trial Update: Cyclooxygenase-2-Inhibitor Combination Treatment for Bipolar Depression [Phase 4]
A Phase 4 clinical trial evaluating a cyclooxygenase-2 inhibitor in combination treatment for bipolar depression has completed, with results…
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CLINICAL_TRIALS trial_result · 2024-01-19Clinical Trial Update: NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar Depression [Phase 3]
Phase 3 trial update for NRX100 versus placebo aiming to rapidly stabilize acute suicidal ideation and behavior in bipolar depression.
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CLINICAL_TRIALS trial_result · 2024-01-19Clinical Trial Update: NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Suicidal Ideation [Phase 3]
Phase 3 trial update for NRX-101 as maintenance treatment in severe bipolar depression with suicidal ideation.
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CLINICAL_TRIALS trial_result · 2023-10-02Clinical Trial Update: PEA vs. Placebo for Major Depression [Phase 2]
Phase 2 clinical trial evaluating PEA versus placebo for major depression, with bipolar depression and major depressive disorder as conditio…
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CLINICAL_TRIALS trial_result · 2023-09-14Clinical Trial Update: Vortioxetine Adjunctive Treatment in Bipolar Depression [Phase 4]
Phase 4 clinical trial update on vortioxetine as adjunctive treatment for bipolar depression.
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CLINICAL_TRIALS trial_result · 2023-09-01Clinical Trial Update: Ketamine Versus Electroconvulsive Therapy in Depression [Phase 3]
Phase 3 trial comparing Ketamine to Electroconvulsive Therapy for depression is suspended.
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CLINICAL_TRIALS trial_result · 2023-05-17Clinical Trial Update: Clinical Trial Evaluating ITI-007 as an Adjunctive Therapy to Lithium or Valproate for the Treatment of Bipolar Depression [Phase 3]
Phase 3 clinical trial evaluating ITI-007 as an adjunctive therapy to lithium or valproate for bipolar depression has completed with results…
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CLINICAL_TRIALS trial_result · 2023-02-08Clinical Trial Update: Trehalose as add-on Therapy in Bipolar Depression [Phase 3]
Phase 3 trial updating trehalose as add-on therapy in bipolar depression has completed.
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CLINICAL_TRIALS trial_result · 2023-01-17Clinical Trial Update: A Study of Lurasidone Compared With Placebo for the Treatment of Bipolar I Depression [Phase 3]
Phase 3 clinical trial comparing lurasidone to placebo for bipolar I depression has been terminated.
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CLINICAL_TRIALS trial_result · 2022-08-09Clinical Trial Update: NRX101 Glx Biomarker Validation Study [Phase 2, Phase 3]
A phase 2/3 clinical trial update for NRX101 focusing on Glx biomarker validation in bipolar depression and suicidal ideation has completed.
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CLINICAL_TRIALS trial_result · 2022-06-29Clinical Trial Update: PET and MRI Brain Imaging of Bipolar Disorder [NA]
Clinical trial update reporting completion and posted results for imaging studies in bipolar disorder and bipolar depression.
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CLINICAL_TRIALS trial_result · 2022-06-03Clinical Trial Update: Lumateperone Monotherapy for the Treatment of Bipolar Depression Conducted Globally [Phase 3]
A global Phase 3 trial of lumateperone as monotherapy for bipolar depression has completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-05-04Clinical Trial Update: Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder [Phase 2, Phase 3]
A Clinical Trials update reports safety and efficacy data for fecal microbiota transplantation in bipolar depression, spanning Phase 2 and P…