B-cell Acute Lymphoblastic Leukemia
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Humanized CD19-Specific CAR T Cells for the Treatment of Patients With Positive Relapsed or Refractory CD19 Positive B-Cell Acute Lymphoblastic Leukemia [Phase 1]
Phase 1 clinical trial evaluating humanized CD19-specific CAR T cells for relapsed or refractory CD19-positive B-cell acute lymphoblastic le…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Chimeric Antigen Receptor Treatment Targeting CD70 (SEVENTY) [Phase 1]
Phase 1 study of a CD70-targeted chimeric antigen receptor (CAR) T-cell therapy named SEVENTY for acute leukemias; the trial is not yet recr…
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: ADCT-602 in Treating Patients With Recurrent or Refractory B-cell Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
A Phase 1/2 trial of ADCT-602 for recurrent or refractory B-cell acute lymphoblastic leukemia has been terminated.
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: Autologous Bedside CD19 CAR T-cell Therapy for B-ALL [EARLY_Phase 1]
An early-phase trial of autologous bedside CD19 CAR T-cell therapy for adult B-cell acute lymphoblastic leukemia is underway. The study is c…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: A Real-world Study on the Treatment of Adult B-cell Acute Lymphoblastic Leukemia With CNCT-19
This document provides a real-world study update evaluating CNCT-19 CAR-T therapy for adults with B-cell acute lymphoblastic leukemia.
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: Cellular Immunotherapy in Treating Patients With High-Risk Acute Lymphoblastic Leukemia [Phase 1]
Phase 1 clinical trial evaluating cellular immunotherapy for high-risk B-cell acute lymphoblastic leukemia, with status listed as active but…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: CD19-CD22-Bispecific Chimeric Antigen Receptor (CAR) T Cell Therapy for Pediatric Patients With Acute Lymphoblastic Leukemia [Phase 1]
This clinical trial update reports on a Phase 1 study of a CD19-CD22 bispecific CAR-T cell therapy for pediatric acute lymphoblastic leukemi…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Allogeneic Second-generation CD19-CAR T Cells for Pediatric Relapsed/Refractory B-ALL [Phase 1]
Phase 1 clinical trial evaluating allogeneic second-generation CD19-CAR T cells for pediatric relapsed/refractory B-cell acute lymphoblastic…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Allogeneic UCB-derived CAR-T for B-ALL [EARLY_Phase 1]
Clinical trial update on an allogeneic umbilical cord blood–derived CAR-T therapy for B-cell acute lymphoblastic leukemia in early Phase 1, …
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: CD19x22 Chimeric Antigen Receptor T-cell Therapy (CAR T) in Pediatric B-ALL [Phase 1]
A Phase 1 clinical trial assessing a CD19x22 CAR T-cell therapy for pediatric B-cell acute lymphoblastic leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: KSV01 Injection as the Therapy for Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia [Phase 1]
This clinical trial update describes Phase 1 testing of KSV01 Injection for relapsed/refractory B-cell acute lymphoblastic leukemia. Recruit…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Assessment of Senl_B19 CAR-T Cells in Relapsed/Refractory CD19+ B-ALL [Phase 2]
A Phase 2 clinical trial is assessing Senl_B19 CAR-T cells for relapsed/refractory CD19+ B-cell acute lymphoblastic leukemia and is currentl…
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CLINICAL_TRIALS trial_result · 2025-11-21Clinical Trial Update: Blinatumomab and Auto-HSCT Sandwich Strategy as Consolidation Therapy for B-ALL [Phase 1]
Phase 1 clinical trial evaluating blinatumomab with autologous hematopoietic stem cell transplantation as consolidation therapy for B-cell a…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: In VIVO CAR-T Therapy for Relapsed/Refractory Hematological Malignancies [Phase 1]
A Phase 1 clinical trial of an in vivo CAR-T therapy for relapsed/refractory hematologic cancers is currently recruiting. The study targets …
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: A Clinical Study to Explore CT1195E in Patients With Relapsed/Refractory B-Cell Neoplasms [Phase 1]
Phase 1 study of CT1195E in relapsed/refractory B-cell neoplasms is not yet recruiting.
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells With or Without NKTR-255 in Adults With Recurrent or Refractory B Cell Malignancies [Phase 1]
A Phase 1 study from Stanford is evaluating CD19/CD22 CAR T cells with or without NKTR-255 in adults with recurrent or refractory B-cell mal…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Activated T Lymphocytes Expressing CARs, Relapsed CD19+ Malignancies Post-Allo HSCT(CARPASCIO) [Phase 1]
Phase 1 trial update of CAR T cells (CARPASCIO) targeting CD19 in relapsed CD19+ malignancies after allogeneic HSCT. The study is currently …
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: CAR T-cell Long-Term Follow-Up, Quality of Life and Adverse Reactions
This clinical trial update reports on long-term follow-up, quality of life outcomes, and adverse reactions for CAR T-cell therapy in B-cell …
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Blinatumomab Consolidation in Real World
A clinical trial evaluating blinatumomab consolidation in real-world settings for B-cell acute lymphoblastic leukemia is currently recruitin…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Blinatumomab & Pembrolizumab for Adults With Relapsed/Refractory B-cell ALL With High Marrow Lymphoblasts [Phase 1, Phase 2]
Results from a Phase 1/2 study evaluating the combination of blinatumomab and pembrolizumab in adults with relapsed/refractory B-cell acute …
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Blinatumomab, Inotuzumab Ozogamicin, and Combination Chemotherapy as Frontline Therapy in Treating Patients With B Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical study evaluating frontline therapy with blinatumomab, inotuzumab ozogamicin, and chemotherapy for B-cell acute lymphoblasti…
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CLINICAL_TRIALS research · 2025-11-05Clinical Trial Update: A Study of Anakinra to Prevent or Treat Severe Side Effects for Patients Receiving CAR-T Cell Therapy [Phase 2]
Phase 2 clinical trial evaluating anakinra to prevent or treat severe side effects in patients receiving CAR-T cell therapy; status is activ…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML [Phase 1]
This is a Phase 1 clinical trial assessing a quadruple combination of ABL001 (asciminib), dasatinib, prednisone, and blinatumomab in patient…
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CLINICAL_TRIALS trial_result · 2025-10-24Clinical Trial Update: A Safety and Efficacy Study Evaluating CTX110 in Subjects With Relapsed or Refractory B-Cell Malignancies (CARBON) [Phase 1, Phase 2]
This clinical trial update reports safety and efficacy data for CTX110 in relapsed or refractory B-cell malignancies, including Non-Hodgkin …
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Blinatumomab Combined With Venetoclax as Maintenance Therapy After Allo-HSCT in High-risk Ph Negative Acute B-cell Lymphoblastic Leukemia [Phase 2]
Phase 2 trial update evaluating blinatumomab in combination with venetoclax as maintenance therapy after allogeneic stem cell transplantatio…