B-cell Acute Lymphoblastic Leukemia
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Blinatumomab Consolidation in Real World
A clinical trial evaluating blinatumomab consolidation in real-world settings for B-cell acute lymphoblastic leukemia is currently recruitin…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Blinatumomab, Inotuzumab Ozogamicin, and Combination Chemotherapy as Frontline Therapy in Treating Patients With B Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical study evaluating frontline therapy with blinatumomab, inotuzumab ozogamicin, and chemotherapy for B-cell acute lymphoblasti…
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CLINICAL_TRIALS research · 2025-11-05Clinical Trial Update: A Study of Anakinra to Prevent or Treat Severe Side Effects for Patients Receiving CAR-T Cell Therapy [Phase 2]
Phase 2 clinical trial evaluating anakinra to prevent or treat severe side effects in patients receiving CAR-T cell therapy; status is activ…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML [Phase 1]
This is a Phase 1 clinical trial assessing a quadruple combination of ABL001 (asciminib), dasatinib, prednisone, and blinatumomab in patient…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Myeloablative Conditioning Orca-T & Allogeneic Donor-Derived CD19/CD22-CAR TCells in B-Cell ALL [Phase 1]
This clinical trial update covers a Phase 1 study evaluating myeloablative conditioning with Orca-T plus donor-derived CD19/CD22-CAR T cells…
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL) [Phase 2]
A Phase 2 trial evaluating Blinatumomab alone versus Blinatumomab with Nivolumab in patients with first-relapse B-cell acute lymphoblastic l…
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CLINICAL_TRIALS research · 2025-09-09Clinical Trial Update: Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01) [Phase 1, Phase 2]
Phase 1/2 clinical trial update for UCART22 evaluating safety and early activity in relapsed or refractory CD22-positive B-cell acute lympho…
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: Newly-diagnosed Low Risk Pediatric B-cell ALL Protocol [Phase 2, Phase 3]
A newly diagnosed, low-risk pediatric B-cell acute lymphoblastic leukemia protocol is described for Phase 2 and Phase 3 testing and is curre…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: A Study of CNCT19 Treatment in Children and Adolescent r/r ALL Patients(Pediatric) [Phase 1, Phase 2]
A pediatric clinical trial evaluating CNCT19, a CAR-T therapy, for relapsed/refractory B-cell acute lymphoblastic leukemia in children and a…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Fourth-gen CAR T Cells Targeting CD19/CD22 for Highly Resistant B-cell Lymphoma/Leukemia (PMBCL/CNS-BCL). [Phase 1, Phase 2]
This Clinical Trial Update describes a fourth-generation CD19/CD22 dual-targeting CAR T-cell therapy being evaluated in Phase 1/2 for highly…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: CD180 CART for Relapsed or Refractory CD180 Positive Hematologic Malignancies [Phase 1]
A Phase 1 trial evaluating CD180 CAR-T therapy for relapsed or refractory CD180-positive hematologic malignancies is currently recruiting, i…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: A Phase 1 Study of FIT-CD19-CAR-T Cells in R/R B-ALL [Phase 1]
Phase 1 study evaluating FIT-CD19-CAR-T Cells for relapsed/refractory B-cell acute lymphoblastic leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: JY231(JY231) Injection for the Treatment of Relapsed or Refractory B Cell Lymphoma/ Leukemia [NA]
A clinical trial update for JY231 injection in relapsed or refractory B-cell lymphomas and leukemias, currently recruiting.
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CLINICAL_TRIALS research · 2025-06-29Clinical Trial Update: A Clinical Study Exploring Universal CAR-T Cell in Patients With Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia [Phase 1]
A Phase 1 clinical study evaluating universal CAR-T cells in patients with relapsed/refractory B-cell acute lymphoblastic leukemia, which is…
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: Study of Nutrition and Exercise in Adults Hospitalized for Treatment of Acute Lymphoblastic Leukemia (ALL) [NA]
Clinical trial update for a nutrition and exercise program in adults undergoing treatment for acute lymphoblastic leukemia (ALL); the study …
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CLINICAL_TRIALS research · 2025-06-10Clinical Trial Update: JY231(JY231) Injection for the Treatment of Relapsed/Refractory B Cell Lymphoma/ Leukemia [NA]
This clinical trial update indicates that JY231 injection is being studied for relapsed/refractory B-cell acute lymphoblastic leukemia and B…
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: CD22/CD19 CAR-T and Auto-HSCT Sandwich Strategy as Consolidation Therapy for B-ALL [Phase 2]
This Phase 2 clinical trial investigates a consolidation strategy using CD22/CD19 CAR-T cells followed by autologous hematopoietic stem cell…
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: The Predictability of CD19 Expression Across Primitive Cellular Fractions of Relapsed B-ALL on Outcomes of CD19-targeted CAR T-cells
This clinical trial explores how CD19 expression across primitive cellular fractions in relapsed B-cell acute lymphoblastic leukemia affects…
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: Intravenous Autologous CD19 CAR-T Cells for R/R B-ALL [Phase 2, Phase 3]
This document provides an update on a Phase 2/Phase 3 trial evaluating intravenously administered autologous CD19 CAR-T cells for relapsed o…
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CLINICAL_TRIALS research · 2025-05-23Clinical Trial Update: Inaticabtagene Autoleucel (Inati-cel; CNCT19) Treatment for MRD-Positive B-ALL Patients in CR1 [Phase 2]
A Phase 2 clinical trial evaluating Inati-cel (CNCT19) CAR-T therapy for MRD-positive B-cell acute lymphoblastic leukemia patients in first …
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CLINICAL_TRIALS research · 2025-05-22Clinical Trial Update: A Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of B019 Injection in Subjects With Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia. [Phase 1]
A Phase 1 study evaluating the safety, tolerability, and preliminary efficacy of B019 Injection in patients with relapsed or refractory B-ce…
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL [Phase 2]
Phase 2 study evaluating elimination of total body irradiation for NGS-MRD negative children, adolescents, and young adults with B-cell acut…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: "Triple Negative" Adult B-cell Acute Lymphoblastic Leukemia - TRINEG-ALL
A clinical trial update for TRINEG-ALL investigating triple-negative adult B-cell acute lymphoblastic leukemia is currently recruiting. Spon…
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CLINICAL_TRIALS research · 2025-04-06Clinical Trial Update: Evaluating the Safety and Efficacy of DuoCAR20.19.22-D95 in Adult Patients With Relapsed or Refractory B-cell Malignancies [Phase 1]
A Phase 1 clinical trial update evaluating the safety and efficacy of DuoCAR20.19.22-D95 in adults with relapsed or refractory B-cell malign…
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: The Application of CAR-T Cell Therapy in Relapsed and Refractory Malignant Hematologic Tumors [Phase 1, Phase 2]
Ongoing Phase 1/Phase 2 trials are evaluating CAR-T cell therapy for relapsed or refractory malignant hematologic tumors, including aggressi…