Autosomal Dominant Polycystic Kidney Disease
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CLINICAL_TRIALS research · 2025-05-08Clinical Trial Update: Statin Therapy in Patients With Early Stage ADPKD [Phase 4]
Phase 4 clinical trial evaluating statin therapy in early-stage autosomal dominant polycystic kidney disease is currently not recruiting.
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CLINICAL_TRIALS research · 2025-05-06Clinical Trial Update: Glucagon-Like Peptide-1 Receptor Agonist in ADPKD [Phase 2]
A Phase 2 clinical trial evaluating an investigational GLP-1 receptor agonist for autosomal dominant polycystic kidney disease, with obesity…
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FDA approval · 2025-04-23FDA Approved: JYNARQUE — Supplemental Application (Otsuka America Pharmaceutical, Inc.)
FDA approved a supplemental application for JYNARQUE (tolvaptan) submitted by Otsuka America Pharmaceutical, Inc. The action pertains to a s…
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CLINICAL_TRIALS trial_result · 2025-04-04Clinical Trial Update: Study of Tamibarotene in Patients With ADPKD [Phase 2]
Phase 2 clinical trial evaluating tamibarotene for Autosomal Dominant Polycystic Kidney Disease (ADPKD) is currently active but not recruiti…
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CLINICAL_TRIALS research · 2025-02-12Clinical Trial Update: Kidney Sodium Functional Imaging
A clinical trial update announcing ongoing recruitment for a study on kidney sodium functional imaging in people with chronic kidney disease…
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CLINICAL_TRIALS research · 2025-01-06Clinical Trial Update: Analysis of Patients With Autosomal Dominant Polycystic Kidney
This document reports an ongoing recruiting clinical trial studying patients with autosomal dominant polycystic kidney disease (ADPKD).
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FDA approval · 2024-12-16FDA Approved: JYNARQUE — Supplemental Application (Otsuka America Pharmaceutical, Inc.)
FDA approved a supplemental application for JYNARQUE (tolvaptan) from Otsuka America Pharmaceutical, potentially updating or expanding its l…
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CLINICAL_TRIALS trial_result · 2024-12-16Clinical Trial Update: Genetic Testing in Autosomal Dominant Polycystic Kidney Disease
A completed clinical trial update reporting results from genetic testing in autosomal dominant polycystic kidney disease.
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CLINICAL_TRIALS research · 2024-12-11Clinical Trial Update: The German ADPKD Tolvaptan Treatment Registry
A German registry sponsored by the University of Cologne is recruiting participants to document tolvaptan treatment in autosomal dominant po…
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CLINICAL_TRIALS research · 2024-11-14Clinical Trial Update: Artificial Intelligence-based Image Processing Methods to Advance the Characterization of Polycystic Kidney Disease
This clinical trial update describes the use of artificial intelligence–based image processing methods to advance the characterization of Au…
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CLINICAL_TRIALS research · 2024-11-07Clinical Trial Update: Shared Decision Making for Choosing Autosomal DOminant Polycystic Kidney Disease Treatment [NA]
This clinical trial update describes a study evaluating shared decision-making to choose treatments for autosomal dominant polycystic kidney…
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CLINICAL_TRIALS trial_result · 2024-11-05Clinical Trial Update: Renal Denervation in ADPKD- RDN-ADPKD Study [NA]
The Renal Denervation in Autosomal Dominant Polycystic Kidney Disease (ADPKD) study is currently active but not recruiting.
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CLINICAL_TRIALS research · 2024-10-26Clinical Trial Update: Study to Evaluate the Drug-drug Interaction of JMKX003142 in Healthy Subjects [Phase 1]
Phase 1 study to evaluate drug-drug interactions of JMKX003142 in healthy subjects; the trial lists Autosomal Dominant Polycystic Kidney Dis…
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CLINICAL_TRIALS trial_result · 2024-08-22Clinical Trial Update: A Study to Evaluate the Effects of GLPG2737 in Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD) [Phase 2]
Phase 2 study evaluating GLPG2737 for Autosomal Dominant Polycystic Kidney Disease was terminated, with results posted on 2024-08-22.
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: Study and Management of Cystic Complications in Autosomal Dominant Polycystic Kidney Disease
This clinical trial update notes a study at University Hospital, Brest investigating management of cystic complications in autosomal dominan…
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CLINICAL_TRIALS trial_result · 2024-06-11Clinical Trial Update: A Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON [Phase 3]
Phase 3 trial of bardoxolone methyl in autosomal dominant polycystic kidney disease was terminated with results posted in 2024.
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CLINICAL_TRIALS research · 2024-05-16Clinical Trial Update: Genetics in the Progression of Nephropathies
A clinical study sponsored by Ospedale San Raffaele is investigating how genetics influence the progression of various kidney-related diseas…
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CLINICAL_TRIALS research · 2024-05-06Clinical Trial Update: Assessment of Longitudinal Changes in Endothelial Function and Oxidative Stress in Normotensive Patients With ADPKD
A Mayo Clinic-sponsored study investigating longitudinal changes in endothelial function and oxidative stress in normotensive patients with …
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CLINICAL_TRIALS trial_result · 2024-03-19Clinical Trial Update: An Extended Access Program for Bardoxolone Methyl in Patients With CKD (EAGLE) [Phase 3]
The Phase 3 extended access program for bardoxolone methyl in chronic kidney disease was terminated, with results posted in March 2024. The …
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CLINICAL_TRIALS trial_result · 2023-10-25Clinical Trial Update: Treat Autosomal Dominant Polycystic Kidney Disease With Oral Ketone Ester? [Phase 2]
Phase 2 clinical trial exploring an oral ketone ester for autosomal dominant polycystic kidney disease (ADPKD).
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FDA approval · 2023-09-29FDA Approved: JYNARQUE — Supplemental Application (Otsuka America Pharmaceutical, Inc.)
The FDA approved a supplemental application for JYNARQUE (tolvaptan) submitted by Otsuka America Pharmaceutical, Inc.
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CLINICAL_TRIALS trial_result · 2023-05-23Clinical Trial Update: Atorvastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease [Phase 2]
Phase 2 clinical trial investigating atorvastatin with alkali therapy in autosomal dominant polycystic kidney disease and chronic kidney dis…
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CLINICAL_TRIALS trial_result · 2023-04-10Clinical Trial Update: Safety of Lixivaptan in Subjects Previously Treated With Tolvaptan for Autosomal Dominant Polycystic Kidney Disease [Phase 3]
Phase 3 trial assessing safety of lixivaptan in adults with autosomal dominant polycystic kidney disease previously treated with tolvaptan; …
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CLINICAL_TRIALS trial_result · 2023-02-06Clinical Trial Update: Study of the Efficacy and Safety of Tesevatinib in Subjects With ADPKD [Phase 2]
Phase 2 trial evaluating the efficacy and safety of tesevatinib in autosomal dominant polycystic kidney disease (ADPKD) has completed with r…
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CLINICAL_TRIALS trial_result · 2023-02-06Clinical Trial Update: Efficacy and Safety of Lixivaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease [Phase 3]
Clinical trial update for lixivaptan in autosomal dominant polycystic kidney disease (ADPKD) in Phase 3; the study was terminated with resul…