Autosomal Dominant Polycystic Kidney Disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW) [Phase 2]
A Phase 2a trial of VX-407 in participants with autosomal dominant polycystic kidney disease who carry a subset of PKD1 gene variants; curre…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: RADIOLOGICAL AND CLINICAL EVALUATION OF RENAL EMBOLIZATION USING EVOH IN DIALYSIS PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE: A PROSPECTIVE LONGITUDINAL OBSERVATIONAL STUDY
This prospective, longitudinal observational study assesses radiologic and clinical outcomes of renal embolization using Ethylene-vinyl alco…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Study to Evaluate Homocysteine Metabolism and Endothelial Function in ADPKD
A Mayo Clinic study evaluating homocysteine metabolism and endothelial function in autosomal dominant polycystic kidney disease; currently a…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD) [Phase 3]
Ongoing Phase 3 trial IMPEDE-PKD is evaluating metformin therapy to slow the decline in kidney function for autosomal dominant polycystic ki…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Developing a Pipeline to Employ RNA-Seq as a Complementary Diagnostic Tool in Rare Diseases [NA]
This clinical trial update describes a project to develop RNA-Seq as a complementary diagnostic tool for rare diseases, with recruitment ong…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Safety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney Disease [Phase 1]
Phase 1 clinical trial evaluating safety, tolerability, and pharmacokinetics of AZD1613 in adults with autosomal dominant polycystic kidney …
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Metabolic Impacts of Ren-Nu: A Dietary Program for Polycystic Kidney Disease [NA]
This clinical trial is recruiting to evaluate the metabolic effects of the Ren-Nu dietary program in autosomal dominant polycystic kidney di…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: STOP-PKD: SGLT2-inhibition to Improve Prognosis in Polycystic Kidney Disease [Phase 3]
Phase 3 STOP-PKD trial evaluating SGLT2 inhibitors to improve prognosis in autosomal dominant polycystic kidney disease. The study is curren…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Phase 1 Study to Evaluate the Safety and Tolerability of Intravenously Administered PYC-003 [Phase 1]
Phase 1 clinical trial evaluating the safety and tolerability of intravenously administered PYC-003 for autosomal dominant polycystic kidney…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: HYDROchlorothiazide to PROTECT Polycystic Kidney Disease Patients and Improve Their Quality of Life [Phase 3]
Phase 3 clinical trial evaluating hydrochlorothiazide to protect autosomal dominant polycystic kidney disease patients and improve quality o…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: A Study to Assess Adverse Events and Effectiveness of IntraVenous Infusions of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD) [Phase 2]
This clinical trial update describes a Phase 2 study assessing the safety and effectiveness of intravenous ABBV-CLS-628 in adult participant…
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CLINICAL_TRIALS research · 2026-01-30Clinical Trial Update: Di-PKD: A Pilot Trial of Dietary Intervention in Patients With Autosomal Dominant Polycystic Kidney Disease [NA]
A pilot study (Di-PKD) is assessing a dietary intervention for Autosomal Dominant Polycystic Kidney Disease. The trial status is NOT_YET_REC…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: A Prospective Observational Study of Foam Sclerotherapy .
This is a prospective observational clinical trial evaluating foam sclerotherapy for cyst-related manifestations in autosomal dominant polyc…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Autosomal Dominant Polycystic Kidney Disease Somatic Mutation Biorepository
This study is a somatic mutation biorepository for Autosomal Dominant Polycystic Kidney Disease and is currently enrolling by invitation.
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Robotic vs Open Nephrectomy for ADPKD
This clinical trials update concerns a study comparing robotic-assisted nephrectomy versus open nephrectomy in Autosomal Dominant Polycystic…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Intrarenal Microvasculature in ADPKD
A Mayo Clinic-sponsored study is investigating intrarenal microvasculature in autosomal dominant polycystic kidney disease. The study is cur…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
This clinical trial update describes a study assessing the Nrf2 response in patients with autosomal dominant polycystic kidney disease and i…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: NOX4 and Related Biomarkers in ADPKD
A Mayo Clinic-sponsored clinical trial (NCT04630613) is recruiting to investigate NOX4 and related biomarkers in Autosomal Dominant Polycyst…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Canadian Medical Assessment of JINARC™ Outcomes Registry
Completed Canadian medical assessment of the JINARC outcomes registry for autosomal Dominant Polycystic Kidney Disease.
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Bempedoic Acid Therapy for Polycystic Kidney Disease [Phase 2]
A Phase 2 clinical trial is evaluating bempedoic acid for autosomal dominant polycystic kidney disease; the study status is not yet recruiti…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
A King’s College London–led clinical trial is recruiting to study hypertension in children and young people at risk of autosomal dominant po…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Study of Empagliflozin in Patients With Autosomal Dominant Polycystic Kidney Disease (EMPA-PKD) [Phase 4]
Phase 4 trial update on empagliflozin for Autosomal Dominant Polycystic Kidney Disease (EMPA-PKD). The study is currently active but not rec…
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Somatosensory Phenotyping of ADPKD
A clinical trial is currently recruiting to study somatosensory phenotyping in autosomal dominant polycystic kidney disease (ADPKD), with a …
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CLINICAL_TRIALS research · 2025-10-27Clinical Trial Update: Role of ROS and cAMP-PKA Biomarkers in ADPKD
Clinical trial update examining reactive oxygen species (ROS) and cAMP-PKA biomarkers in autosomal dominant polycystic kidney disease (ADPKD…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: Drug-Drug Interaction of JMKX003142 With Amiodarone and Febuxostat in Healthy Subjects [Phase 1]
Phase 1 clinical trial assessing potential drug-drug interaction between JMKX003142 and amiodarone and febuxostat in healthy subjects; the l…