Aplastic Anemia
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CLINICAL_TRIALS research · 2016-07-14Clinical Trial Update: Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload
This clinical trial update outlines the use of MRI monitoring in patients with aplastic anemia and low- to intermediate-1-risk myelodysplast…
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CLINICAL_TRIALS trial_result · 2016-05-17Clinical Trial Update: Extended Platelet Parameters as a Means to Differentiate Immune Thrombocytopenia From Hypo-proliferative Thrombocytopenias.
This completed clinical trial from Beth Israel Medical Center evaluated whether extended platelet parameters can distinguish immune thromboc…
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CLINICAL_TRIALS trial_result · 2016-05-13Clinical Trial Update: Drug Etiology of Aplastic Anemia and Related Dyscrasias
NHLBI-sponsored clinical trial evaluating etiologies of aplastic anemia and related dyscrasias has completed.
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CLINICAL_TRIALS research · 2016-05-13Clinical Trial Update: Etiology of Blood Dyscrasias: Analysis of the International Agranulocytosis and Aplastic Anemia Study Data
This trial update analyzes data from the International Agranulocytosis and Aplastic Anemia Study to explore the etiology of blood dyscrasias…
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CLINICAL_TRIALS withdrawal · 2016-04-20Clinical Trial Update: Collection of Blood and Bone Marrow From Patients With Aplastic Anemia for Analysis of Adhesion Molecules, Chemokines and Their Receptors
The study collecting blood and bone marrow from patients with aplastic anemia (and healthy volunteers) to analyze adhesion molecules, chemok…
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CLINICAL_TRIALS trial_result · 2016-04-14Clinical Trial Update: Cord Blood Stem Cell Transplantation Study (COBLT) [Phase 2]
Phase 2 COBLT cord blood stem cell transplantation trial sponsored by NHLBI has completed, studying transplantation for aplastic anemia, Fan…
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CLINICAL_TRIALS research · 2016-04-05Clinical Trial Update: Comparison of Two Different Doses of Rabbit ATG-Fresenius With Cyclosporin in the Treatment of Acquired Aplastic Anaemia [NA]
A clinical trial update evaluating two different doses of rabbit ATG-Fresenius with cyclosporin for acquired aplastic anemia.
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CLINICAL_TRIALS trial_result · 2016-03-03Clinical Trial Update: Peripheral Blood Stem Cell Transplantation (PBSCT)From Haploidentical Related Donors [Phase 2]
Phase 2 results from a trial of peripheral blood stem cell transplantation using haploidentical related donors were completed, led by the Un…
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CLINICAL_TRIALS trial_result · 2016-03-03Clinical Trial Update: Rabbit Antithymocyte Globulin Versus Campath-1H for Treating Severe Aplastic Anemia [Phase 2]
Phase 2 trial comparing Rabbit Antithymocyte Globulin to Campath-1H for severe aplastic anemia; study completed with results posted in 2016.
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CLINICAL_TRIALS trial_result · 2016-03-02Clinical Trial Update: A Pilot Study of Fludarabine Plus Cyclophosphamide in Refractory Severe Aplastic Anemia [Phase 1, Phase 2]
A pilot study evaluating fludarabine plus cyclophosphamide in refractory severe aplastic anemia completed phases 1 and 2 with results posted…
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CLINICAL_TRIALS trial_result · 2016-02-18Clinical Trial Update: Aplastic Anemia Epidemiology: Incidence and Case-control
This ClinicalTrials.gov entry reports a completed epidemiological study on aplastic anemia, focusing on its incidence and a case-control ana…
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CLINICAL_TRIALS trial_result · 2015-12-23Clinical Trial Update: T-cell Depleted Bone Marrow and G-CSF Stimulated Peripheral Stem Cell Transplantation From Related Donors in Treating Patients With Leukemia, Lymphoblastic Lymphoma, Myelodysplastic Syndrome, or Aplastic Anemia [Phase 2]
Phase 2 clinical trial update evaluating T-cell-depleted bone marrow and G-CSF-stimulated peripheral stem cell transplantation from related …
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CLINICAL_TRIALS trial_result · 2015-11-11Clinical Trial Update: Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating cyclophosphamide plus cyclosporine in treatment-naive severe aplastic anemia; the study status is comple…
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CLINICAL_TRIALS trial_result · 2015-05-14Clinical Trial Update: A Study to Determine Whether Therapy With Daclizumab Will Benefit Patients With Bone Marrow Failure [Phase 2]
Phase 2 trial evaluating daclizumab for bone marrow failure (aplastic anemia and related conditions) was terminated; results posted in 2015.
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CLINICAL_TRIALS trial_result · 2015-04-03Clinical Trial Update: Safety and Efficacy of Patient's Own AD-MSC and AD-HSC Transplantation in Patients With Severe Aplastic Anemia [Phase 1, Phase 2]
This clinical trial update discusses the safety and efficacy of autologous adipose-derived mesenchymal stem cells (AD-MSC) and autologous ad…
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CLINICAL_TRIALS trial_result · 2014-10-28Clinical Trial Update: Safety and Efficacy of Desferasirox in Chinese Patients With Iron Overload and Aplastic Anemia [Phase 4]
Phase 4 study assessing the safety and efficacy of Desferasirox in Chinese patients with iron overload and aplastic anemia.
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CLINICAL_TRIALS research · 2014-10-08Clinical Trial Update: Safety Study of CD3/CD19 Depleted Haploidentical Stem Cells [Phase 1, Phase 2]
A Phase 1/2 safety study evaluating CD3/CD19 depleted haploidentical stem cell transplants in pediatric patients with acute leukemia, aplast…
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CLINICAL_TRIALS research · 2014-09-25Clinical Trial Update: Mesenchymal Stem Cells Co-transplantation in Alternative Donor Transplantation of Severe Aplastic Anemia. [Phase 2]
Phase 2 clinical trial evaluating co-transplantation of mesenchymal stem cells in alternative donor transplantation for severe aplastic anem…
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CLINICAL_TRIALS trial_result · 2014-09-11Clinical Trial Update: Investigation of the Cylex® ImmuKnow® Assay
A completed clinical trial investigating the Cylex ImmuKnow immune function assay across several hematologic diseases.
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FDA approval · 2014-08-26FDA Approved: PROMACTA — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for PROMACTA (eltrombopag olamine) submitted by Novartis Pharmaceuticals Corporation.
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CLINICAL_TRIALS research · 2014-08-20Clinical Trial Update: Pharmacokinetic Study of Fludarabine in Pediatric Hematopoietic Stem Cell Transplantation [Phase 2]
Phase 2 pharmacokinetic study of fludarabine in pediatric patients undergoing hematopoietic stem cell transplantation, sponsored by Seoul Na…
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CLINICAL_TRIALS research · 2014-08-18Clinical Trial Update: Treatment Protocol of Child SAA With the Injection of Mesenchymal Stem Cells（Umbilical Cord Derived） [Phase 4]
Phase 4 clinical trial protocol update evaluating infusion of umbilical cord-derived mesenchymal stem cells to treat children with severe ap…
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CLINICAL_TRIALS trial_result · 2014-07-28Clinical Trial Update: Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia [Phase 2]
Phase 2 trial update for rituximab in treating moderate aplastic anemia, pure red cell aplasia, or Diamond-Blackfan anemia with completed st…
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CLINICAL_TRIALS trial_result · 2014-03-31Clinical Trial Update: T-Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignancies [Phase 2]
Phase 2 clinical trial evaluating T-cell depleted allogeneic stem cell transplantation for hematologic malignancies; study is completed with…
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CLINICAL_TRIALS research · 2014-03-26Clinical Trial Update: Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination [Phase 1, Phase 2]
Open-label Phase 1/2 clinical trial evaluating the safety and tolerability of donor-derived allogeneic B-cell concentrates to support immune…