Apical Periodontitis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Vital Pulp Therapy Versus Root Canal Treatment for Irreversible Pulpitis With Incipient Apical Periodontitis Diagnosed Using Artificial Intelligence This Keeps: the Main Intervention (Vital Pulp Therapy) the Comparison (Root Canal Treatment) the Condition (Irreversible Pulpitis With Incipient Apic [NA]
A clinical trial at Ain Shams University comparing vital pulp therapy to root canal treatment for symptomatic irreversible pulpitis with inc…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: The Aim of This Study is to Evaluate the Relationship Between Genetic Polymorphisms and Periapical Lesion Healing in Individuals With Chronic Apical Periodontitis at Clinical and Radiological Levels.
A clinical trial update describing a study to evaluate the relationship between genetic polymorphisms and healing of periapical lesions in c…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis [NA]
A clinical trial evaluating the effectiveness of oleanolic acid as an intracanal medicament to reduce infection and inflammation in apical p…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: In Vivo Study on the Material Properties of iRoot SP and nRoot SP Root Canal Sealers [NA]
An in vivo study is being conducted to evaluate the material properties of iRoot SP and nRoot SP root canal sealers for chronic apical perio…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: The Effect of Anti-inflammatory Cryoagent on the Level of Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis and Apical Periodontitis. [Phase 2]
Phase 2 clinical trial assessing the anti-inflammatory Cryoagent for reducing postoperative pain in patients with symptomatic irreversible p…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: Effect of Integrated Apex Locator Motor Modes on Postoperative Pain in Endodontic Retreatment [NA]
A completed clinical trial evaluating whether integrated apex locator motor modes affect postoperative pain after endodontic retreatment.
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: MMP-2/3 and Periapical Healing Outcomes
A clinical trial update from TC Erciyes University examines the involvement of MMP-2/3 in chronic apical periodontitis and periapical healin…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Apical Periodontitis and Mental Health
A University of Siena–sponsored clinical trial evaluating the relationship between apical periodontitis and mental health has completed. The…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Nanozymes in Endodontics [Phase 4]
A Phase 4 trial update on nanozyme-based therapy for endodontic diseases. The study is not yet recruiting.
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CLINICAL_TRIALS other · 2026-04-08Clinical Trial Update: Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment [NA]
Clinical trial update from the University of Alabama at Birmingham evaluating disinfection technologies for non-surgical retreatment of mola…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Biomarkers in Apical Periodontitis
A clinical trial update from Kırıkkale University studies biomarkers and cytokines in apical periodontitis with retreatment, and is currentl…
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Effect of I-PRF Application on ALP and MMP-9 Levels in Teeth With Apical Periodontitis
This completed clinical trial evaluated whether applying i-PRF affects alkaline phosphatase and MMP-9 levels in teeth with apical periodonti…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Single Versus Multiple Visits Regenerative Endodontics in Mature Teeth [NA]
This completed clinical trial evaluated single versus multiple visits regenerative endodontics in mature teeth affected by chronic apical pe…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Apical Preparation Size in Regenerative Endodontics of Mature Teeth [NA]
A completed clinical trial evaluating apical preparation size in regenerative endodontics for mature teeth.
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CLINICAL_TRIALS trial_result · 2026-03-11Clinical Trial Update: Efficacy of Lasers in Root Canal Treatment, Part II: Postoperative Pain [Phase 2]
A Phase 2 clinical trial evaluating the efficacy of lasers in reducing postoperative pain after root canal treatment has completed. The stud…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment [NA]
A clinical trial evaluating the effectiveness of i-PRF as a revitalization approach in non-surgical root canal retreatment, currently recrui…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France
A France-based clinical trial evaluating professional practices among dental surgeons for treating non-vital primary teeth, including cases …
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Evaluation of the Effect of Leukocyte and Platelet-rich Fibrin on Healing After Periradicular Surgery [NA]
A completed clinical trial evaluated whether leukocyte- and platelet-rich fibrin (L-PRF) improves healing after periradicular surgery in api…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Interleukin 8 and10 Levels Changes in Teeth With Necrotic Pulp and Apical Periodontitis [NA]
A completed clinical trial evaluating changes in interleukin-8 and interleukin-10 levels in teeth with necrotic pulp and apical periodontiti…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: INVESTIGATION OF THE EFFECT OF DIFFERENT ACTIVATION TECHNIQUES ON TLR9, IL6, IL10, TNF-ALFA LEVELS IN HEALTHY AND TYPE 2 DIABETIC PATIENTS WITH APICAL PERIODONTITIS REQUIRING RETREATMENT
Sponsored clinical trial to assess how different activation techniques affect inflammatory biomarkers (TLR9, IL-6, IL-10, TNF-alpha) in heal…
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CLINICAL_TRIALS trial_result · 2026-02-04Clinical Trial Update: Effectiveness of Laser-activated Photoacoustic Flow in One-visit Revision of Teeth With Apical Periodontitis [NA]
An update on an active, not-recruiting clinical trial from the University of Zagreb evaluating laser-activated photoacoustic flow for one-vi…
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CLINICAL_TRIALS trial_result · 2026-02-03Clinical Trial Update: Success of Pulpotomy in Molars With Pulpitis With Periodontitis Detected Using AI and Those Without Periodontitis [NA]
A completed clinical trial evaluated the success of pulpotomy in molars with pulpitis, comparing cases with AI-detected periodontitis to tho…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Effect of Different Chelation Protocols on the Healing of Periapical Lesions in Teeth With Chronic Apical Periodontitis [NA]
The document describes a clinical trial evaluating how different chelation protocols affect the healing of periapical lesions in teeth with …
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CLINICAL_TRIALS trial_result · 2026-01-20Clinical Trial Update: Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis
This clinical trial investigates the antibacterial activity of calcium hydroxide and betamethasone in apical periodontitis and is currently …
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Endodontic Microsurgery [Phase 4]
A Phase 4 clinical trial update for endodontic microsurgery addressing apical periodontitis; the study is not yet recruiting.