Anaplastic Thyroid Carcinoma

• CLINICAL_TRIALS trial_result · 2026-03-23
  Clinical Trial Update: IMRT Followed by Pembrolizumab in the Adjuvant Setting in Anaplastic Cancer of the Thyroid (IMPAACT): Phase II Trial Adjuvant Pembrolizumab After IMRT in ATC [Phase 2]

  This Phase II IMPAACT trial evaluated adjuvant pembrolizumab after IMRT in anaplastic thyroid carcinoma. The study was terminated, and resul…

• CLINICAL_TRIALS trial_result · 2026-02-27
  Clinical Trial Update: DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers. [Phase 2, Phase 3]

  The DETERMINE trial's Arm 07 is studying dabrafenib plus trametinib in patients with BRAF V600 mutation-positive cancers across age groups; …

• CLINICAL_TRIALS trial_result · 2025-11-24
  Clinical Trial Update: DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers. [Phase 2, Phase 3]

  Phase 2/3 DETERMINE trial treatment arm 05 is evaluating the combination of vemurafenib and cobimetinib in adults with BRAF-positive cancers…

• CLINICAL_TRIALS trial_result · 2025-11-21
  Clinical Trial Update: A Study to Characterize the Safety, Tolerability, and Preliminary Efficacy of CFT1946 as Monotherapy and Combination Therapy in Subjects With BRAF V600 Mutant Solid Tumors [Phase 1]

  Phase 1 study evaluating CFT1946 as monotherapy and in combination for BRAF V600-mutant solid tumors to assess safety, tolerability, and pre…

• CLINICAL_TRIALS trial_result · 2025-11-13
  Clinical Trial Update: Selpercatinib Before Surgery for the Treatment of RET-Altered Thyroid Cancer [Phase 2]

  Phase 2 clinical trial evaluating selpercatinib given before surgery for RET-altered thyroid cancers is currently active but not recruiting.

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• CLINICAL_TRIALS trial_result · 2025-10-20
  Clinical Trial Update: Vudalimab for the Treatment of Locally Advanced or Metastatic Anaplastic Thyroid Cancer or Hurthle Cell Thyroid Cancer [Phase 2]

  Phase 2 clinical trial update for Vudalimab in locally advanced or metastatic anaplastic thyroid carcinoma and oncocytic (Hurthle cell) thyr…

• CLINICAL_TRIALS trial_result · 2025-06-19
  Clinical Trial Update: Trial of Cabozantinib Plus Atezolizumab in Advanced and Progressive Neoplasms of the Endocrine System. The CABATEN Study [Phase 2]

  Phase 2 CABATEN trial evaluated cabozantinib in combination with atezolizumab for advanced neuroendocrine neoplasms of the endocrine system.…

• CLINICAL_TRIALS trial_result · 2021-05-14
  Clinical Trial Update: Intensity-Modulated Radiation Therapy and Paclitaxel With or Without Pazopanib Hydrochloride in Treating Patients With Anaplastic Thyroid Cancer [Phase 2]

  Phase 2 trial evaluating intensity-modulated radiation therapy and paclitaxel with or without pazopanib for anaplastic thyroid carcinoma has…

• CLINICAL_TRIALS trial_result · 2019-10-15
  Clinical Trial Update: A Phase 2 Trial of Lenvatinib for the Treatment of Anaplastic Thyroid Cancer (ATC) [Phase 2]

  Phase 2 trial of lenvatinib for anaplastic thyroid carcinoma was terminated with results posted in 2019.

• CLINICAL_TRIALS trial_result · 2019-08-28
  Clinical Trial Update: Pembrolizumab, Chemotherapy, and Radiation Therapy With or Without Surgery in Treating Patients With Anaplastic Thyroid Cancer [Phase 2]

  Phase 2 trial evaluating pembrolizumab with chemotherapy and radiation, with or without surgery, in anaplastic thyroid carcinoma; study comp…

• CLINICAL_TRIALS trial_result · 2017-08-03
  Clinical Trial Update: Sorafenib Phase II Study for Japanese Anaplastic or Medullary Thyroid Carcinoma Patients [Phase 2]

  This update reports the completion of Bayer-sponsored Phase II trial evaluating sorafenib in Japanese patients with anaplastic or medullary …

• CLINICAL_TRIALS trial_result · 2015-12-31
  Clinical Trial Update: A Phase I/II Trial of Crolibulin (EPC2407) Plus Cisplatin in Adults With Solid Tumors With a Focus on Anaplastic Thyroid Cancer (ATC) [Phase 1, Phase 2]

  A Phase I/II clinical trial evaluating Crolibulin (EPC2407) in combination with cisplatin in adults with solid tumors, focusing on anaplasti…

• CLINICAL_TRIALS trial_result · 2014-06-09
  Clinical Trial Update: Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid Cancer [Phase 2, Phase 3]

  A phase 2/3 trial evaluating combretastatin with paclitaxel and carboplatin for anaplastic thyroid carcinoma was terminated, with results po…

• CLINICAL_TRIALS trial_result · 2014-04-21
  Clinical Trial Update: Trial Evaluating Gleevec in Patients With Anaplastic Thyroid Carcinoma [Phase 2]

  A Phase 2 trial evaluating imatinib (Gleevec) in patients with anaplastic thyroid carcinoma was terminated, with results posted in 2014.

• CLINICAL_TRIALS trial_result · 2013-02-28
  Clinical Trial Update: Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu [Phase 1]

  A Phase 1 trial tested the combination of Interleukin-12 and trastuzumab in HER2/Neu-overexpressing cancers and the study has completed.

• CLINICAL_TRIALS trial_result · 2010-06-11
  Clinical Trial Update: Combretastatin A4 Phosphate in Treating Patients With Advanced Anaplastic Thyroid Cancer [Phase 2]

  Phase 2 trial update for Combretastatin A4 Phosphate in advanced anaplastic thyroid carcinoma (a form of head and neck cancer); the study st…

• CLINICAL_TRIALS trial_result · 2010-06-11
  Clinical Trial Update: Induction Chemotherapy Using Doxorubicin and Cisplatin Followed by Combretastatin A4 Phosphate and Radiation Therapy in Treating Patients With Newly Diagnosed Regionally Advanced Anaplastic Thyroid Cancer [Phase 1, Phase 2]

  A terminated Phase 1/2 trial evaluating induction chemotherapy with doxorubicin and cisplatin followed by combretastatin A4 phosphate and ra…