Anaplastic Astrocytoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2013-06-10Clinical Trial Update: Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma [Phase 2]
A Phase 2 clinical trial evaluating ritonavir and lopinavir for progressive or recurrent high-grade glioma was terminated, with results post…
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CLINICAL_TRIALS trial_result · 2013-02-20Clinical Trial Update: PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas [Phase 1]
A Phase I trial evaluated adding a Farnesyl Transferase Inhibitor to temozolomide in patients with Grade 3-4 malignant gliomas, and the stud…
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CLINICAL_TRIALS trial_result · 2013-01-24Clinical Trial Update: Bortezomib in Treating Patients With Recurrent Glioma [Phase 1]
Phase 1 trial evaluating bortezomib in adults with recurrent glioma; the study has been terminated.
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CLINICAL_TRIALS trial_result · 2013-01-16Clinical Trial Update: Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction [Phase 1]
Phase 1 clinical trial evaluating erlotinib in patients with solid tumors and liver or kidney dysfunction has been completed.
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CLINICAL_TRIALS research · 2013-01-16Clinical Trial Update: Use of EF5 to Measure the Oxygen Level in Tumor Cells of Patients Undergoing Surgery or Biopsy for Newly Diagnosed Supratentorial Malignant Glioma [NA]
A terminated clinical trial evaluated the use of EF5 to measure oxygen levels in tumor cells of patients with newly diagnosed supratentorial…
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CLINICAL_TRIALS trial_result · 2013-01-16Clinical Trial Update: Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors [Phase 1]
This document is a terminated Phase 1 trial update evaluating PET imaging with 18F-EF5 to measure oxygenation in brain tumor cells of adults…
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FDA approval · 2013-01-08FDA Approved: TEMODAR — Supplemental Application (Merck Sharp & Dohme LLC)
The FDA approved a supplemental application for TEMODAR (temozolomide) submitted by Merck Sharp & Dohme LLC, resulting in an approved change…
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CLINICAL_TRIALS trial_result · 2012-11-30Clinical Trial Update: Tumor DNA and MRI/CT Scan Findings in Patients With Grade III or Grade IV Malignant Glioma [NA]
This completed clinical trial update reports on tumor DNA and MRI/CT imaging findings in patients with grade III or grade IV malignant gliom…
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CLINICAL_TRIALS withdrawal · 2012-11-21Clinical Trial Update: Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma [Phase 1]
A Phase I trial of dasatinib in combination with protracted temozolomide for recurrent malignant glioma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2012-11-16Clinical Trial Update: Phase IIa Safety and Light Dose-escalation Study in Patients With Primary or Recurrent/High-grade Glioma Using the Litx™ System to Confirm the Zone of Tumor Destruction During the Intraoperative Treatment of Glioma [Phase 2]
Phase IIa safety and light-dose escalation trial in patients with primary or recurrent high-grade glioma using the Litx System to define the…
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CLINICAL_TRIALS trial_result · 2012-10-31Clinical Trial Update: A Phase II Trial of Sutent (Sunitinib; SU011248) for Recurrent Anaplastic Astrocytoma and Glioblastoma [Phase 2]
A Phase II trial evaluated sunitinib (Sutent) for recurrent anaplastic astrocytoma and glioblastoma. The results were posted in October 2012…
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CLINICAL_TRIALS trial_result · 2012-09-13Clinical Trial Update: Leflunomide in Treating Patients With Anaplastic Astrocytoma in First Relapse [Phase 2]
Pfizer-sponsored Phase 2 trial evaluating Leflunomide in patients with first-relapse anaplastic astrocytoma has completed.
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CLINICAL_TRIALS trial_result · 2012-08-31Clinical Trial Update: Tandutinib Plus Bevacizumab to Treat Recurrent Brain Tumors [Phase 2]
A Phase 2 trial evaluated tandutinib in combination with bevacizumab for recurrent brain tumors, with results posted in 2012.
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CLINICAL_TRIALS trial_result · 2012-08-29Clinical Trial Update: Treatment of Newly Diagnosed Brain Tumors With Chemotherapy and Radiation Using Cells Modified for Chemoprotection and an Experimental Drug to Decrease the Tumor Cell Resistance to Chemotherapy [Phase 1]
A Phase 1 trial evaluating chemotherapy and radiation with chemoprotective cells and an experimental drug to reduce chemotherapy resistance …
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CLINICAL_TRIALS trial_result · 2012-08-03Clinical Trial Update: Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Newly Diagnosed Malignant Glioma [Phase 3]
Phase 3 clinical trial evaluating intracranially implanted carmustine for newly diagnosed malignant glioma, assessing safety and efficacy. T…
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CLINICAL_TRIALS trial_result · 2012-07-11Clinical Trial Update: Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Recurrent Malignant Glioma [NA]
A clinical trial update describes a safety and efficacy study of intracranially implanted Carmustine for recurrent malignant glioma, with th…
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CLINICAL_TRIALS withdrawal · 2012-02-22Clinical Trial Update: Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas [Phase 3]
A Phase 3 trial assessing procarbazine with isotretinoin for recurrent primary malignant gliomas has been withdrawn.
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CLINICAL_TRIALS trial_result · 2012-02-06Clinical Trial Update: Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors [Phase 1, Phase 2]
This clinical trial update summarizes the results of a Phase 1/2 study evaluating lapatinib in pediatric patients with recurrent or refracto…
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CLINICAL_TRIALS trial_result · 2011-12-30Clinical Trial Update: Phase III Trial of Primary Radio- or Chemotherapy in Malignant Astrocytoma of the Elderly [Phase 3]
A Phase III trial evaluating primary radiotherapy or chemotherapy in elderly patients with malignant astrocytoma (glioblastoma or anaplastic…
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CLINICAL_TRIALS trial_result · 2011-12-09Clinical Trial Update: Phase II Study of Irinotecan HCI for Recurrent Anaplastic Astrocytomas, Mixed Malignant Gliomas, and Oligodendrogliomas [Phase 2]
Phase II trial of irinotecan hydrochloride in recurrent anaplastic astrocytoma, mixed malignant glioma, and oligodendroglioma was terminated…
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CLINICAL_TRIALS trial_result · 2011-07-11Clinical Trial Update: Gefitinib and Radiation Therapy in Treating Children With Newly Diagnosed Gliomas [Phase 1, Phase 2]
A pediatric Phase 1/2 trial evaluated gefitinib in combination with radiation therapy for newly diagnosed gliomas; the study completed and r…
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CLINICAL_TRIALS trial_result · 2011-07-04Clinical Trial Update: IL13-PE38QQR Infusion After Tumor Resection, Followed by Radiation Therapy With or Without Temozolomide in Patients With Newly Diagnosed Malignant Glioma [Phase 1]
Phase 1 trial evaluating IL13-PE38QQR infusion after surgical resection, followed by radiation therapy with or without temozolomide, in pati…
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CLINICAL_TRIALS trial_result · 2011-06-06Clinical Trial Update: Pre-operative IL13-PE38QQR in Patients With Recurrent or Progressive Malignant Glioma [Phase 1, Phase 2]
This clinical trial update reports completion of a Phase 1/2 study evaluating IL13-PE38QQR as a pre-operative therapy in patients with recur…
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CLINICAL_TRIALS trial_result · 2011-06-06Clinical Trial Update: Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients [Phase 1]
A completed Phase 1 trial assessed histologic effects and safety of pre/post-operative IL13-PE38QQR in patients with recurrent resectable su…
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CLINICAL_TRIALS trial_result · 2011-06-06Clinical Trial Update: Imaging Study of the Distribution of IL13-PE38QQR Infused Before and After Surgery in Adult Patients With Recurrent Malignant Glioma [Phase 1]
Phase 1 imaging study evaluating how the IL13-PE38QQR conjugate distributes in adult patients with recurrent malignant glioma before and aft…