Anaplastic Astrocytoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2024-02-02Clinical Trial Update: Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma [Phase 1]
This entry describes a Phase 1 clinical trial of a genetically engineered HSV-1 therapy for recurrent malignant glioma, including glioblasto…
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CLINICAL_TRIALS trial_result · 2024-01-03Clinical Trial Update: Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas [Phase 1]
Phase 1 trial evaluating adavosertib with local radiation in children with newly diagnosed diffuse intrinsic pontine glioma; results are pos…
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CLINICAL_TRIALS trial_result · 2023-05-22Clinical Trial Update: Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas [Phase 1, Phase 2]
Phase I/II trial of AXL1717 in recurrent malignant astrocytomas (glioblastoma, gliosarcoma) with terminated status and results posted.
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CLINICAL_TRIALS trial_result · 2023-01-20Clinical Trial Update: Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma [Phase 1]
Phase 1 trial update of neural stem cell–based virotherapy for newly diagnosed malignant glioma; study completed with results posted in 2023…
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CLINICAL_TRIALS trial_result · 2022-08-15Clinical Trial Update: Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children [Phase 2]
Phase 2 pilot study of cabozantinib for recurrent or progressive central nervous system tumors in children has been terminated; results were…
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CLINICAL_TRIALS trial_result · 2022-08-10Clinical Trial Update: Laser Interstitial Thermal Therapy and Lomustine in Treating Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma [Phase 2]
Phase 2 trial exploring laser interstitial thermal therapy with lomustine in recurrent glioblastoma or anaplastic astrocytoma; the study is …
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CLINICAL_TRIALS trial_result · 2022-08-09Clinical Trial Update: Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 [Phase 1, Phase 2]
Phase 1/2 trial evaluating intraarterial cetuximab (Erbitux) and bevacizumab for relapsed/refractory intracranial glioma in patients under 2…
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CLINICAL_TRIALS trial_result · 2022-01-21Clinical Trial Update: Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients [Phase 3]
Phase 3 trial comparing eflornithine plus lomustine versus lomustine alone in recurrent anaplastic astrocytoma patients; current status unkn…
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CLINICAL_TRIALS trial_result · 2021-09-29Clinical Trial Update: Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas [Phase 1]
Phase 1 trial evaluating genetically modified neural stem cells with flucytosine and leucovorin for recurrent high-grade gliomas; results co…
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CLINICAL_TRIALS trial_result · 2021-09-28Clinical Trial Update: Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma [Phase 1, Phase 2]
This ClinicalTrials.gov update reports a terminated Phase 1/2 study evaluating Zotiraciclib (TG02) in combination with dose-dense or metrono…
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CLINICAL_TRIALS trial_result · 2021-07-21Clinical Trial Update: Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma [Phase 2]
Phase 2 trial evaluating valproic acid with radiation and bevacizumab in pediatric high-grade gliomas and diffuse intrinsic pontine glioma h…
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CLINICAL_TRIALS trial_result · 2020-03-12Clinical Trial Update: Efficacy of Hypofractionated XRT w/Bev. + Temozolomide for Recurrent Gliomas [Phase 2]
Phase 2 trial evaluating hypofractionated external radiotherapy with bevacizumab and temozolomide for recurrent gliomas; the study was termi…
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CLINICAL_TRIALS trial_result · 2020-03-03Clinical Trial Update: Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma [Phase 1, Phase 2]
Phase 1/2 trial evaluating Vorinostat with radiation followed by maintenance therapy in younger patients with newly diagnosed diffuse intrin…
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CLINICAL_TRIALS trial_result · 2020-02-07Clinical Trial Update: The Toca 5 Trial: Toca 511 & Toca FC Versus Standard of Care in Patients With Recurrent High Grade Glioma [Phase 2, Phase 3]
Clinical trial update for Toca 511 & Toca FC in recurrent high-grade glioma (Phase 2/3) has been terminated.
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CLINICAL_TRIALS trial_result · 2020-01-02Clinical Trial Update: Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme [Phase 1]
Phase 1 trial update for a viral therapy in recurrent glioblastoma multiforme with related glioma conditions; results posted.
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CLINICAL_TRIALS trial_result · 2019-09-09Clinical Trial Update: Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas [Phase 1]
Phase 1 trial evaluating alisertib in combination with fractionated stereotactic radiosurgery for adults with recurrent high-grade gliomas h…
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CLINICAL_TRIALS trial_result · 2018-08-16Clinical Trial Update: Efficacy of Two Temozolomide Regimens in Adjuvant Treatment of Patients With Brain High Grade Glioma [Phase 3]
A Phase 3 clinical trial comparing two temozolomide regimens for adjuvant treatment in high-grade glioma of the brain, including glioblastom…
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CLINICAL_TRIALS trial_result · 2018-07-20Clinical Trial Update: Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors [Phase 2]
A Phase 2 trial evaluating imetelstat in younger patients with recurrent or refractory brain tumors was terminated, with results posted in J…
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CLINICAL_TRIALS trial_result · 2018-07-09Clinical Trial Update: Pharmacokinetics in Patients With Newly Diagnosed High-Grade Glioma Receiving Temozolomide and Radiation Therapy
This clinical trial update reports pharmacokinetic data from a study of temozolomide with radiation therapy in patients with newly diagnosed…
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CLINICAL_TRIALS trial_result · 2018-07-05Clinical Trial Update: (11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas
A clinical trial evaluating the PET tracer 11C-dLop as a marker of P-glycoprotein function in gliomas was terminated. The study enrolled pat…
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CLINICAL_TRIALS trial_result · 2018-07-03Clinical Trial Update: Yoga Therapy in Treating Patients With Malignant Brain Tumors [NA]
This entry notes a terminated clinical trial at Wake Forest evaluating yoga therapy for adults with malignant brain tumors.
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CLINICAL_TRIALS trial_result · 2018-07-02Clinical Trial Update: Carboplatin in Treating Patients With Recurrent High-Grade Gliomas [Phase 1]
Phase 1 results from a carboplatin trial in patients with recurrent high-grade gliomas, including adults with anaplastic astrocytoma and ana…
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CLINICAL_TRIALS trial_result · 2018-05-21Clinical Trial Update: Study of a Retroviral Replicating Vector Combined With a Prodrug to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor [Phase 1]
Phase 1 study evaluating Tocagen's retroviral replicating vector Toca 511 in combination with the prodrug 5-fluorocytosine for recurrent mal…
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CLINICAL_TRIALS trial_result · 2018-05-21Clinical Trial Update: Study of a Retroviral Replicating Vector Given Intravenously to Patients Undergoing Surgery for Recurrent Brain Tumor [Phase 1]
This document reports the completion of a Phase 1 trial evaluating a retroviral replicating vector (Toca 511) given intravenously to patient…
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CLINICAL_TRIALS trial_result · 2018-05-21Clinical Trial Update: A Study of a Retroviral Replicating Vector Combined With a Prodrug Administered to Patients With Recurrent Malignant Glioma [Phase 1]
Phase 1 study evaluating the safety and feasibility of Toca 511, a retroviral replicating vector, in combination with the prodrug Toca FC in…