Amyloidosis
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CLINICAL_TRIALS other · 2025-08-28Clinical Trial Update: BE.Amycon Registry UZ Leuven
The BE.Amycon Registry trial at Universitaire Ziekenhuizen KU Leuven is currently suspended.
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Pan-Amyloid PET/CT in Various Amyloid-Related Disease
This entry notes a recruiting clinical trial sponsored by Tianjin Medical University evaluating pan-amyloid PET/CT imaging across amyloid-re…
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CLINICAL_TRIALS research · 2025-04-20Clinical Trial Update: Clinical Trial to Assess the Safety of a Novel Scaffold Biomaterial [NA]
This entry reports an active-not-recruiting Mayo Clinic clinical trial assessing the safety of a novel scaffold biomaterial in patients with…
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CLINICAL_TRIALS trial_result · 2025-03-12Clinical Trial Update: Ixazomib Rollover Study [Phase 2]
A Phase 2 Ixazomib rollover study has completed, with results posted on 2025-03-12. The study encompassed multiple myeloma, lymphoma, and am…
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CLINICAL_TRIALS trial_result · 2025-02-12Clinical Trial Update: Screening for Amyloidosis Before Aortic Valve Elective Replacement
Charite University in Berlin is screening for amyloidosis in patients undergoing elective aortic valve replacement; the trial (NCT04869631) …
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CLINICAL_TRIALS trial_result · 2025-01-29Clinical Trial Update: carDIo-ttranSSfOrm nucLEar Imaging Study
The carDIo-ttranSSfOrm nucLEar Imaging Study, sponsored by Oregon Health and Science University, has been terminated. The study involves amy…
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CLINICAL_TRIALS trial_result · 2025-01-09Clinical Trial Update: Dietary Reporting in the Amyloidoses [NA]
This clinical trial update reports a recruiting study sponsored by the Barbara Ann Karmanos Cancer Institute investigating dietary reporting…
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CLINICAL_TRIALS research · 2024-12-09Clinical Trial Update: Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF [NA]
A Massachusetts General Hospital study is recruiting to assess how common transthyretin amyloidosis is and how to predict its presence in am…
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CLINICAL_TRIALS research · 2024-11-14Clinical Trial Update: FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases
FLOWER is a longitudinal epidemiology study by xCures to follow outcomes across multiple rare diseases, and the study is currently recruitin…
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CLINICAL_TRIALS trial_result · 2024-11-06Clinical Trial Update: MargheRITA (Remote Intelligence for Therapeutic Adherence) [NA]
A completed clinical trial named MargheRITA (Remote Intelligence for Therapeutic Adherence) sponsored by Advice Pharma Group srl studied tre…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: A Single Dose Study to Evaluate the Pharmacokinetics of Acoramidis Modified Release Formulations in Healthy Subjects [Phase 1]
Phase 1 pharmacokinetic study evaluating acoramidis modified-release formulations in healthy subjects has been completed.
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CLINICAL_TRIALS other · 2024-07-30Clinical Trial Update: Affection of Renal and Urinary System in IBD Patients
Clinical trial update for a study on kidney and urinary system issues in inflammatory bowel disease patients; recruitment has not started.
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CLINICAL_TRIALS research · 2024-05-07Clinical Trial Update: Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
This document summarizes a tissue repository that provides annotated biospecimens for investigator-directed biomedical research, with ongoin…
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CLINICAL_TRIALS trial_result · 2024-04-17Clinical Trial Update: Frontline Lenalidomide for AL Amyloidosis Involving Myocardium [Phase 3]
Phase 3 trial evaluating frontline lenalidomide for amyloidosis involving the heart has completed.
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EMA approval · 2024-01-17EMA Authorised: Tegsedi (inotersen sodium) — Akcea Therapeutics Ireland Limited
EMA authorises Tegsedi (inotersen sodium) for amyloidosis, with orphan medicine designation and accelerated assessment.
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CLINICAL_TRIALS trial_result · 2023-12-06Clinical Trial Update: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Participants Who Have Already Been Treated With ALN-TTR02 (Patisiran) [Phase 3]
Phase 3 trial update for patisiran in patients with transthyretin-mediated amyloidosis who have already been treated with patisiran; study c…
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CLINICAL_TRIALS trial_result · 2023-10-25Clinical Trial Update: APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma [Phase 1, Phase 2]
Phase 1/2 trial evaluating APG-2575 in combination regimens for relapsed or refractory multiple myeloma and amyloidosis.
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CLINICAL_TRIALS trial_result · 2023-07-24Clinical Trial Update: A Study to Desensitize Allergic Reactions to Treatments for Blood Disorders [Phase 2]
Phase 2 clinical trial update on desensitization for allergic reactions to treatments used for blood disorders, completed.
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CLINICAL_TRIALS trial_result · 2023-05-24Clinical Trial Update: Propylene Glycol-Free Melphalan Hydrochloride (Evomela) in AL Amyloidosis Patients [Phase 2]
A Phase 2 clinical trial evaluating propylene glycol-free melphalan hydrochloride (Evomela) in systemic amyloidosis (AL type) has been termi…
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CLINICAL_TRIALS trial_result · 2023-01-25Clinical Trial Update: Lenalidomide, Dexamethasone, and Elotuzumab With or Without Cyclophosphamide in Treating Patients With Relapsed Primary Amyloidosis [Phase 2]
Phase 2 clinical trial evaluating lenalidomide, dexamethasone, and elotuzumab with or without cyclophosphamide in relapsed primary amyloidos…
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CLINICAL_TRIALS trial_result · 2022-12-13Clinical Trial Update: Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal Disease [NA]
A completed clinical trial investigating combined bone marrow and renal transplantation for hematologic disorders in patients with end-stage…
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CLINICAL_TRIALS trial_result · 2021-07-09Clinical Trial Update: Daratumumab Therapy for Patients With Refractory or Relapsed AL Amyloidosis [Phase 2]
Phase 2 trial evaluating daratumumab therapy in patients with refractory or relapsed amyloidosis has been completed.
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CLINICAL_TRIALS trial_result · 2021-04-30Clinical Trial Update: Lenalidomide, Dexamethasone and Cyclophosphamide in Amyloidosis (AL) [Phase 1, Phase 2]
Phase 1/2 clinical trial of lenalidomide, dexamethasone, and cyclophosphamide in amyloidosis (AL) completed.
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CLINICAL_TRIALS trial_result · 2021-04-15Clinical Trial Update: A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis [Phase 1, Phase 2]
A dose-escalation study of carfilzomib with thalidomide and dexamethasone in relapsed AL amyloidosis has completed Phase 1/2, with results p…
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CLINICAL_TRIALS trial_result · 2020-12-04Clinical Trial Update: Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy [Phase 1, Phase 2]
Phase 1/2 trial investigating doxycycline and TUDCA in transthyretin amyloid cardiomyopathy has completed with results posted.