Adrenocortical Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-08-26Clinical Trial Update: Evaluation of Side Effects of Mitotane
A clinical trial update on evaluating the side effects of mitotane in patients with adrenocortical carcinoma.
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma
Preclinical immunotherapy program for adrenocortical carcinoma is described, with Cushing's syndrome listed as a condition; the trial status…
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CLINICAL_TRIALS trial_result · 2025-06-19Clinical Trial Update: A Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Mitotane in Patients With Advanced Adrenocortical Carcinoma [Phase 2]
Phase II study evaluating pembrolizumab in combination with mitotane for advanced adrenocortical carcinoma has been terminated, with results…
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Phase II Study of PD-1 Inhibitor Combined With Apatinib and Mitotane in the Treatment of Advanced Adrenal Cortical Carcinoma [Phase 2]
Phase II study evaluating a PD-1 inhibitor in combination with apatinib and mitotane for advanced adrenocortical carcinoma; the trial is cur…
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CLINICAL_TRIALS research · 2025-04-29Clinical Trial Update: Phase II Study of PD-1 Antibody Combined With Radiotherapy in Recurrent or Metastatic Adrenal Cortical Carcinoma [Phase 2]
A Phase II clinical trial is evaluating a PD-1 antibody in combination with radiotherapy for recurrent or metastatic adrenocortical carcinom…
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CLINICAL_TRIALS research · 2025-04-02Clinical Trial Update: Pembrolizumab in the Treatment of Advanced, Progressive Adrenocortical Carcinoma. [Phase 2]
A Phase 2 clinical trial evaluating pembrolizumab for advanced, progressive adrenocortical carcinoma is currently recruiting.
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CLINICAL_TRIALS research · 2025-03-11Clinical Trial Update: National Study of Adrenal Tumours
An update on a national study of adrenal tumours, currently enrolling by invitation and focusing on pheochromocytoma, paraganglioma, adrenoc…
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CLINICAL_TRIALS research · 2025-02-12Clinical Trial Update: Adrenal Project: Clinical and Epidemiological Characterization of Adrenocortical Carcinoma in a Brazilian Cohort
An ongoing observational study in Brazil aims to characterize adrenocortical carcinoma clinically and epidemiologically in a Brazilian cohor…
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CLINICAL_TRIALS trial_result · 2024-12-10Clinical Trial Update: Cabozantinib in Treating Patients With Locally Advanced or Metastatic Unresectable Adrenocortical Carcinoma [Phase 2]
A Phase 2 trial of cabozantinib in locally advanced or metastatic unresectable adrenocortical carcinoma has completed and results were poste…
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CLINICAL_TRIALS trial_result · 2024-12-09Clinical Trial Update: Phase 1 Study of 68Ga-R8760 [Phase 1]
The Phase 1 trial of the radiopharmaceutical 68Ga-R8760 for adrenocortical carcinoma has been terminated.
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CLINICAL_TRIALS trial_result · 2024-11-20Clinical Trial Update: A Study of OSI-906 in Patients With Locally Advanced or Metastatic Adrenocortical Carcinoma [Phase 3]
This is an update on a Phase 3 trial evaluating OSI-906 (linsitinib) in locally advanced or metastatic adrenocortical carcinoma. The study h…
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FDA approval · 2024-10-28FDA Approved: LYSODREN — Supplemental Application (ESTEVE PHARMACEUTICALS, S.A.)
The FDA approved a supplemental application for LYSODREN (mitotane) submitted by Esteve Pharmaceuticals, S.A.
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CLINICAL_TRIALS trial_result · 2024-08-19Clinical Trial Update: Cabozantinib in Advanced Adrenocortical Carcinoma [Phase 2]
A Phase 2 clinical trial evaluating cabozantinib for advanced adrenocortical carcinoma is ongoing, with no results or status information pro…
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CLINICAL_TRIALS trial_result · 2024-08-01Clinical Trial Update: Adjuvant Chemotherapy vs. Observation/Mitotane After Primary Surgical Resection of Localized Adrenocortical CarcInoma [Phase 3]
Phase 3 trial comparing adjuvant chemotherapy versus observation with mitotane after surgical resection of localized adrenocortical carcinom…
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CLINICAL_TRIALS research · 2024-08-01Clinical Trial Update: Evaluation of the Efficacy of Addition of Progesterone to Standard Chemotherapy in Adrenocortical Carcinoma (ACC) [Phase 2]
A Phase 2 clinical trial is assessing whether adding progesterone to standard chemotherapy improves outcomes in adrenocortical carcinoma, wi…
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CLINICAL_TRIALS research · 2024-07-17Clinical Trial Update: Phase II Study for Combination of Camrelizumab and Apatinib in the Second-line Treatment of Recurrent or Metastatic Adrenocortical Carcinoma [Phase 2]
Phase II trial evaluating camrelizumab in combination with apatinib as second-line therapy for recurrent or metastatic adrenocortical carcin…
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CLINICAL_TRIALS trial_result · 2024-06-18Clinical Trial Update: Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic [Phase 2]
Phase 2 study of pembrolizumab in patients with rare, unresectable or metastatic solid tumors; results have been posted.
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FDA label_change · 2024-01-09FDA Approved: LYSODREN — Supplemental Application (ESTEVE PHARMACEUTICALS, S.A.)
FDA approved a supplemental application for LYSODREN (mitotane) submitted by Esteve Pharmaceuticals, resulting in changes to the product lab…
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FDA approval · 2021-06-15FDA Approved: LYSODREN — Supplemental Application (ESTEVE PHARMACEUTICALS, S.A.)
The FDA approved a supplemental application for LYSODREN (mitotane) submitted by Esteve Pharmaceuticals, S.A., resulting in approval of a re…
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CLINICAL_TRIALS trial_result · 2020-01-06Clinical Trial Update: Single Agent Pembrolizumab in Subjects With Advanced Adrenocortical Carcinoma [Phase 2]
Phase 2 trial evaluating pembrolizumab as a single agent in advanced adrenocortical carcinoma has posted results. The study status is active…
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CLINICAL_TRIALS trial_result · 2019-07-30Clinical Trial Update: Surgery and Heated Chemotherapy for Adrenocortical Carcinoma [Phase 2]
Phase 2 trial evaluating surgery with heated chemotherapy for adrenocortical carcinoma has completed with results posted.
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CLINICAL_TRIALS trial_result · 2019-05-01Clinical Trial Update: Nivolumab in Treating Patients With Metastatic Adrenocortical Cancer [Phase 2]
Phase 2 clinical trial of nivolumab in metastatic/adrenal cortex carcinoma (adrenocortical cancer) has been terminated with results posted.
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CLINICAL_TRIALS trial_result · 2019-01-31Clinical Trial Update: Sunitinib in Refractory Adrenocortical Carcinoma [Phase 2]
A Phase 2 trial of sunitinib in patients with refractory adrenocortical carcinoma has completed, with results posted in January 2019.
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CLINICAL_TRIALS research · 2019-01-18Clinical Trial Update: Salivary Free Cortisol Response to Cosyntropin Stimulation Test in Mitotane Treated Patients [NA]
An update on salivary free cortisol response to a cosyntropin stimulation test in patients treated with mitotane for adrenocortical carcinom…
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CLINICAL_TRIALS trial_result · 2019-01-16Clinical Trial Update: A Dose Finding Study of TKM-080301 Infusion in Neuroendocrine Tumors (NET) and Adrenocortical Carcinoma (ACC) Patients [Phase 1, Phase 2]
Phase 1/2 dose-finding study of TKM-080301 infusion in neuroendocrine tumors and adrenocortical carcinoma has been completed.