On Chronic Liver Failure
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients [Phase 2]
Phase II clinical trial of AS1501 for acute-on-chronic liver failure in China is currently not recruiting.
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CLINICAL_TRIALS research · 2025-03-19Clinical Trial Update: A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial). [Phase 2]
Phase 2 clinical trial evaluating a combinatorial therapy using albumin and enoxaparin in patients with decompensated cirrhosis at high risk…
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CLINICAL_TRIALS research · 2025-03-10Clinical Trial Update: Single Cell Landscape of HBV-related Acute-on-chronic Liver Failure Patients
This clinical trial analyzes single-cell gene expression in patients with HBV-related acute-on-chronic liver failure to map immune and liver…
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CLINICAL_TRIALS research · 2025-02-25Clinical Trial Update: The Safety ,Tolerability and Efficacy Study of HepaCure in Chinese Subjects with Acute-On-Chronic Liver Failure [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial assessing the safety, tolerability, and preliminary efficacy of HepaCure in Chinese patients with acute-on-…
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CLINICAL_TRIALS research · 2025-02-20Clinical Trial Update: Study About Hepatic Toxins Kinetic and Evaluation of Organ Damage in Acute on Chronic Liver Failure (ACLF) Patients
An ongoing clinical trial evaluating hepatic toxins kinetics and organ damage in patients with acute on chronic liver failure (ACLF), curren…
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CLINICAL_TRIALS research · 2025-02-13Clinical Trial Update: MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver Transplantation [Phase 1]
A Phase 1 clinical trial entry evaluating mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) for acute liver failure and acute-o…
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CLINICAL_TRIALS research · 2025-02-10Clinical Trial Update: Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections. [NA]
A clinical trial evaluating the efficacy and safety of ceftazidime-avibactam versus extended-infusion high-dose meropenem for nosocomial inf…
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CLINICAL_TRIALS research · 2025-02-07Clinical Trial Update: Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed [Phase 2, Phase 3]
A Phase 2/3 clinical trial comparing continuous infusion of terlipressin versus bolus terlipressin in patients with acute on chronic liver f…
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CLINICAL_TRIALS research · 2025-02-04Clinical Trial Update: Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial) [NA]
This document describes the GOAL Trial, a clinical study assessing an ammonia-lowering therapy in patients with acute-on-chronic liver failu…
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CLINICAL_TRIALS research · 2024-12-18Clinical Trial Update: Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients [Phase 1, Phase 2]
Clinical trial evaluating the efficacy and safety of BMSCs (CG-BM1) for acute-on-chronic liver failure, currently in Phase 1/2 and recruitin…
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CLINICAL_TRIALS research · 2024-12-10Clinical Trial Update: COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device [NA]
Clinical trial update for the COOLEY study evaluating the CytoSorb hemoadsorption device in acute-on-chronic liver failure; the study is cur…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF [NA]
A recruiting clinical trial evaluating three nucleotide/nucleoside analogue therapies for hepatitis B-related acute-on-chronic liver failure…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF
A clinical trial is recruiting to evaluate the combination of DPMAS and low-volume plasma exchange for patients with chronic hepatitis B-rel…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Long-term Prognosis of Patients With Hepatitis B Related Acute-on-chronic Liver Failure
A study assessing the long-term prognosis of patients with hepatitis B-related acute-on-chronic liver failure is currently recruiting.
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CLINICAL_TRIALS research · 2024-08-16Clinical Trial Update: Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock [NA]
A clinical trial update evaluating whether continuous infusion of terlipressin with norepinephrine improves outcomes compared with norepinep…
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CLINICAL_TRIALS research · 2024-05-31Clinical Trial Update: Study on Prognosis of Acute-on-chronic Liver Failure Complicated by Bacterial or Fungal Infection
A clinical trial sponsored by Qin Ning is recruiting to study the prognosis of acute-on-chronic liver failure when complicated by bacterial …
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CLINICAL_TRIALS research · 2024-05-07Clinical Trial Update: Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure [Phase 1, Phase 2]
This clinical trial is a Phase 1/Phase 2 study evaluating human umbilical cord mesenchymal stem cell transplantation for acute-on-chronic li…
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CLINICAL_TRIALS research · 2024-04-26Clinical Trial Update: To Determine the Predictors of Reversibility for Acute-on-Chronic Liver Failure at 6-months.
This clinical trial update aims to identify predictors of reversibility for acute-on-chronic liver failure at 6 months.
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CLINICAL_TRIALS research · 2019-02-07Clinical Trial Update: Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure" [NA]
This document provides a clinical trial update on plasma exchange in cirrhotic patients with acute-on-chronic liver failure, focusing on eff…
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CLINICAL_TRIALS research · 2018-06-06Clinical Trial Update: Exploring Biomarkers Predicting the Outcome of Acute-on-chronic Liver Failure
A completed clinical trial update describing research into biomarkers that predict outcomes in acute-on-chronic liver failure, with relevanc…
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CLINICAL_TRIALS research · 2017-11-17Clinical Trial Update: Early Versus Late CRRT in ACLF Patients With Septic Shock and AKI [NA]
This clinical trial update discusses a study comparing early versus late continuous renal replacement therapy in patients with acute-on-chro…
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CLINICAL_TRIALS research · 2016-06-24Clinical Trial Update: UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver Failure [Phase 2]
Phase 2 clinical trial investigating infusion of umbilical cord-derived mesenchymal stem cells (UC-MSC) for HBV-related acute-on-chronic liv…
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CLINICAL_TRIALS research · 2016-05-02Clinical Trial Update: Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography [Phase 4]
Phase 4 clinical trial update evaluating coagulation abnormalities in patients with acute-on-chronic liver failure using thromboelastography…
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CLINICAL_TRIALS research · 2016-04-26Clinical Trial Update: A Trial of Ribavirin in Patients With ACLF Due to Hepatitis E Virus [Phase 2]
This clinical trial update describes a Phase 2 study evaluating ribavirin in patients with acute-on-chronic liver failure due to Hepatitis E…
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CLINICAL_TRIALS research · 2013-10-11Clinical Trial Update: Prognosis Scoring System for Acute-on-Chronic Liver Failure
A clinical trial update regarding a prognosis scoring system being studied for acute-on-chronic liver failure, sponsored by the Third Affili…