On Chronic Liver Failure
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Bidirectional Cohort Study of a Prognosis Model for Acute-on-chronic Liver Failure
A bidirectional cohort study is being conducted to develop a prognosis model for acute-on-chronic liver failure. The study status is ACTIVE_…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device. [Phase 3]
A Phase 3 clinical trial (NCT07347275) of DIALIVE 2.0, an extracorporeal liver dialysis device, for acute-on-chronic liver failure and liver…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial) [NA]
This clinical trial entry describes a study called DPMAS-ACLF evaluating double plasma separation and adsorption in acute-on-chronic liver f…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial [NA]
A clinical trial protocol evaluating vitamin C for acute kidney injury in patients with acute-on-chronic liver failure and septic shock, cur…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Assessment of Changes in Bone Mineral Metabolism After Liver Transplantation by Bone Mineral Densitometry
A recruiting clinical trial is investigating how bone mineral metabolism changes after liver transplantation, assessed by bone mineral densi…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: EGEN-5784 Porcine Liver With the Metra® ELC Device [Phase 1]
Phase 1 trial update for EGEN-5784 porcine liver with the Metra ELC device, evaluating use in acute-on-chronic liver failure and hepatic enc…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure. [NA]
A clinical trial is evaluating early initiation of midodrine to control and prevent ascites and related complications in patients with acute…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure [EARLY_Phase 1]
Early-phase Phase 1 clinical trial update on PT-MSCs Exosome Injection for Acute-on-Chronic Liver Failure; the study is currently active but…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF [NA]
Clinical trial update on ALSS using DPMAS and therapeutic plasma exchange to assess effects on coagulation, inflammation and organ function …
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients [NA]
This clinical trial update describes evaluating the Double Plasma Molecular Adsorption System in patients with acute-on-chronic liver failur…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis [NA]
Clinical trial evaluating the efficacy and safety of cytokine adsorption and plasma exchange in patients with acute-on-chronic liver failure…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Risk Factors Affecting MSC Efficacy in ACLF Patients
A clinical trial update examining factors that affect the efficacy of mesenchymal stem cell therapy in patients with acute-on-chronic liver …
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: F573 for Injection for the Treatment of Liver Injury/Failure [Phase 2]
Phase 2 clinical trial update for F573 for Injection in acute liver failure and acute-on-chronic liver failure, currently recruiting.
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
This clinical trial update discusses indications for liver transplantation in patients with cirrhosis and severe acute-on-chronic liver fail…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: CytOSorb TreatMent Of Critically Ill PatientS Registry
A Clinical Trials registry update shows that CytoSorbents is recruiting for a registry trial evaluating Cytosorb hemoadsorption in criticall…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficacy of Mesenchymal Stem-Cell (MSC) Therapy in Non-Viral Acute-on-Chronic Liver Failure (ACLF) [Phase 1]
Phase I study evaluating mesenchymal stem-cell therapy for acute-on-chronic liver failure; currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-08-20Clinical Trial Update: National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial [Phase 2]
Phase II clinical trial evaluating mesenchymal stem cell therapy for non-viral acute-on-chronic liver failure; currently not yet recruiting,…
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study
A multicenter retrospective cohort study assessing prognosis of cirrhotic patients admitted to general intensive care units from 2014–2024. …
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: A-TANGO Phase 2 Study [Phase 2]
A-TANGO is a Phase 2 clinical trial by Yaqrit Ltd evaluating an investigational therapy for acute-on-chronic liver failure and alcoholic hep…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: Biomarkers in Liver Failure
A University of Edinburgh–sponsored biomarker study on liver failure, covering acute liver failure, acute liver injury, and acute-on-chronic…
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CLINICAL_TRIALS research · 2025-07-01Clinical Trial Update: Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy [NA]
A clinical trial update describing ongoing recruitment for a study comparing two ROTEM-based thresholds for transfusing blood products befor…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults [Phase 1]
Phase 1 clinical trial evaluating micro-encapsulated hepatocytes delivered intraperitoneally for adults with liver failure is currently recr…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Continuous Renal Replacement Therapy Intensity in Hyperammonemia [NA]
A clinical trial is evaluating the effect of different intensities of continuous renal replacement therapy on hyperammonemia in patients wit…
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CLINICAL_TRIALS research · 2025-05-08Clinical Trial Update: Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLF [NA]
Feasibility pilot trial to evaluate the safety and performance of the MEX-CD1 medical device in acute-on-chronic liver failure and multiple …
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CLINICAL_TRIALS research · 2025-04-22Clinical Trial Update: Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as a Prognostic Predictor Among Patients With Acute on Top of Chronic Liver Cell Failure
A clinical trial led by Assiut University is investigating whether neutrophil-to-lymphocyte ratio and mean platelet volume can serve as prog…