Acute Myeloid Leukemia
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: CER-1236 in Patients With Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), and Myelofibrosis (MF) [Phase 1]
CERo Therapeutics is conducting a Phase 1 trial of CER-1236 for acute myeloid leukemia, myelodysplastic syndrome, and myelofibrosis; the stu…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]
This clinical trial update notes a Phase 1 study of BAL0891 by SillaJen in patients with advanced solid tumors, including triple-negative br…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML) [Phase 1]
A Phase 1 clinical trial evaluating gilteritinib in combination with either ivosidenib or enasidenib in patients with acute myeloid leukemia…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Standard-dose vs Intermediate-dose Cytarabine Induction in the Treatment of Acute Myeloid Leukemia With RUNX1-RUNX1T1 [Phase 3]
Phase 3 trial comparing standard-dose versus intermediate-dose cytarabine induction in acute myeloid leukemia with RUNX1-RUNX1T1 fusion; cur…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation [Phase 3]
This clinical trial update notes the ongoing Phase 3 study of Revumenib in combination with intensive chemotherapy for newly diagnosed acute…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Revumenib in Combination With 7+3 + Midostaurin in AML [Phase 1]
Phase 1 trial evaluating Revumenib in combination with standard 7+3 chemotherapy and midostaurin for adult acute myeloid leukemia; currently…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Safety and Proof-of-Concept Study of RPT1G in Adults With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes [Phase 1]
Phase 1 safety and proof-of-concept study of the experimental drug RPT1G in adults with acute myeloid leukemia and high-risk myelodysplastic…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: VAG Versus Standard Chemotherapy With FLT3 Inhibitor in Adult Patients With FLT3-Mutated AML [Phase 3]
A Phase 3 trial comparing the VAG regimen with a FLT3 inhibitor to standard chemotherapy in adults with FLT3-mutated acute myeloid leukemia,…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide [Phase 1]
Phase 1 clinical trial update evaluating expanded/activated gamma delta T-cell infusion after hematopoietic stem cell transplantation with p…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms
This clinical trial update discusses a study of acquired pyruvate kinase deficiency in clonal myeloid neoplasms. The trial is currently acti…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: RAD001 in Combination With PKC412 in Patients With Relapsed, Refractory or Poor Prognosis AML or MDS [Phase 1]
Phase 1 clinical trial update evaluating the combination of everolimus (RAD001) with midostaurin (PKC412) in relapsed, refractory, or poor-p…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: Trial to Compare Efficacy and Safety of Chemotherapy/Quizartinib vs Chemotherapy/Placebo in Adults FMS-like Tyrosine Kinase 3 (FLT3) Wild-type Acute Myeloid Leukemia (AML) [Phase 2]
A Phase 2 trial comparing chemotherapy plus quizartinib versus chemotherapy plus placebo in adults with FLT3-wild-type acute myeloid leukemi…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Ruxolitinib in Combination With Venetoclax With and Without Azacitidine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]
Phase 1 clinical trial evaluating ruxolitinib in combination with venetoclax with and without azacitidine for relapsed or refractory acute m…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]
The update describes a Phase 1 trial investigating CD83 CAR T cells for relapsed or refractory acute myeloid leukemia, and the study is curr…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1) [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating Enzomenib (DSP-5336) for acute leukemias, including acute myeloid leukemia and acute lymphoblastic leu…
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CLINICAL_TRIALS trial_result · 2026-03-23Clinical Trial Update: Cytarabine and Daunorubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia [Phase 1]
Phase 1 clinical trial evaluating cytarabine and daunorubicin hydrochloride in adults with newly diagnosed acute myeloid leukemia; results h…
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CLINICAL_TRIALS trial_result · 2026-03-23Clinical Trial Update: A Proof of Concept Pilot Study of the Addition of Venetoclax to Standard Remission Induction Chemotherapy Fludarabine or Cladrabine, Cytarabine, and Granulocyte Colony Stimulating Factor (G-CSF) (FLAG or CLAG) for Frontline Therapy of Secondary Acute Myeloid Leukemia [Phase 2]
Phase 2 trial evaluating adding venetoclax to FLAG/CLAG induction therapy for frontline treatment of secondary acute myeloid leukemia; the s…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Phase IB/II of CPX-351 for Relapse Prevention in AML [Phase 1, Phase 2]
Clinical trial update on CPX-351 for relapse prevention in acute myeloid leukemia in remission; the Phase 1/Phase 2 study is currently recru…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Venetoclax, Azacitidine, and Mitoxantrone Hydrochloride Liposome Versus Idarubicin and Cytarabine in Newly Diagnosed AML [Phase 3]
A Phase 3 clinical trial compares Venetoclax with Azacitidine and Mitoxantrone hydrochloride liposome versus Idarubicin and Cytarabine in ne…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Phase I Study of HC-7366 for Acute Myeloid Leukemia [Phase 1]
A Phase I clinical trial investigating HC-7366 for Acute Myeloid Leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial [Phase 3]
This entry details a Phase 3 extension study of Venetoclax for patients who completed prior Venetoclax trials. The study is currently active…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Aclarubicin Plus With Azacitidine and Venetoclax in the Treatment of Acute Myeloid Leukemia [Phase 1, Phase 2]
This clinical trial update outlines an early-phase (Phase 1/2) study evaluating the combination of aclarubicin with azacitidine and venetocl…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: A Multicenter RCT of "3+7" vs Venetoclax + CACAG in Newly Diagnosed Mid/High-Risk AML Patients [Phase 2]
This document describes a Phase 2 multicenter randomized trial comparing the standard 3+7 chemotherapy regimen to Venetoclax plus CACAG in n…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: MRD-guided Maintenance Post-HCT: Gilteritini vs Sorafenib [Phase 3]
Phase 3 trial comparing MRD-guided maintenance therapy with gilteritinib versus sorafenib after allogeneic hematopoietic cell transplantatio…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Ruxolitinib-Decitabine Intensified Conditioning Regimen for AML: A Randomized Trial [Phase 4]
A Phase 4 randomized trial is evaluating an intensified conditioning regimen combining ruxolitinib and decitabine for patients with acute my…