Acute Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-03-13Clinical Trial Update: Targeting Acute Myeloid Leukemia Immunosuppressive Microenvironment by combinedIDO1 Inhibition and PD-1 Blockade
A clinical trial is evaluating a combination of an IDO1 inhibitor and PD-1 blockade to target the immunosuppressive microenvironment in acut…
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CLINICAL_TRIALS research · 2025-03-12Clinical Trial Update: Efficacy of Gilteritinib in Combination With FLAI as Induction Therapy of FLT3-positive Acute Myeloid Leukemia [Phase 2]
A Phase 2 clinical trial is evaluating the efficacy of gilteritinib in combination with the FLAI induction regimen for FLT3-mutated acute my…
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CLINICAL_TRIALS withdrawal · 2025-03-12Clinical Trial Update: A Phase 1B/2A Trial of Combination of ASTX727 With ASTX029 in Acute Myeloid Leukemia [Phase 1, Phase 2]
A Phase 1B/2A trial evaluating the combination of ASTX727 with ASTX029 for Acute Myeloid Leukemia has been withdrawn.
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CLINICAL_TRIALS research · 2025-03-11Clinical Trial Update: Off-the-shelf CD123 CAR-NK for R/R AML [EARLY_Phase 1]
Early Phase 1 trial evaluating off-the-shelf CD123 CAR-NK cells for relapsed or refractory acute myeloid leukemia; currently recruiting.
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CLINICAL_TRIALS research · 2025-03-10Clinical Trial Update: A Clinical Trial of BP1002 in Patients With Refractory/Relapsed Acute Myeloid Leukemia (AML) [Phase 1]
A Phase 1 clinical trial evaluating BP1002 in patients with refractory or relapsed acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-03-10Clinical Trial Update: Study of Oral PCLX-001 in R/R Acute Myeloid Leukemia [Phase 1]
A Phase 1 clinical trial evaluating oral PCLX-001 for relapsed or refractory acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Safety and Preliminary Efficacy of Donor-derived Anti-leukemia Cytotoxic T Lymphocytes for the Prevention of Leukemia Relapse in Children Given Haploidentical Hematopoietic Stem Cell Transplantation [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating donor-derived anti-leukemia cytotoxic T lymphocytes for preventing relapse after haploidentical stem cel…
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease [Phase 2]
Phase 2 trial evaluating an umbilical cord blood transplant regimen with cyclophosphamide, fludarabine, and total-body irradiation for hemat…
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Reduced Intensity Flu/Mel/TBI Conditioning for HAPLO HCT Patients With Hematologic Malignancies [Phase 2]
Phase 2 trial evaluating reduced-intensity conditioning with fludarabine and melphalan plus total body irradiation for haploidentical stem c…
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CLINICAL_TRIALS research · 2025-03-07Clinical Trial Update: Clinical Trial of BP1001 in Combination With With Venetoclax Plus Decitabine in AML [Phase 2]
This clinical trial update concerns a Phase 2 study of BP1001 in combination with venetoclax and decitabine for acute myeloid leukemia, whic…
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: A Study of CG-806 in Patients With Relapsed or Refractory AML or Higher-Risk MDS [Phase 1]
A Phase 1 study evaluating CG-806 in patients with relapsed or refractory acute myeloid leukemia or higher-risk myelodysplastic syndromes ha…
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies
This completed clinical trial evaluated myeloablative hematopoietic progenitor cell transplantation in pediatric patients with chronic myelo…
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CLINICAL_TRIALS trial_result · 2025-03-06Clinical Trial Update: Study to Evaluate Adverse Events and Movement of Intravenously (IV) Infused ABBV-787 in Adult Participants With Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) [Phase 1]
A Phase 1 study evaluating adverse events and intravenous ABBV-787 in adults with relapsed/refractory acute myeloid leukemia has been termin…
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CLINICAL_TRIALS trial_result · 2025-03-06Clinical Trial Update: 2157GCCC:Phase 1 of Calaspargase Pegol-mknl W/ Cytarabine and Idarubicin in Newly Dx AML [Phase 1]
Phase 1 clinical trial evaluating Calaspargase Pegol-mknl in combination with cytarabine and idarubicin for newly diagnosed acute myeloid le…
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CLINICAL_TRIALS trial_result · 2025-03-05Clinical Trial Update: LILRB4 STAR-T Cells in the Treatment of R/R AML/CMML [Phase 1]
A Phase 1 trial evaluating LILRB4 STAR-T Cells for relapsed/refractory acute myeloid leukemia and chronic myelomonocytic leukemia has comple…
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CLINICAL_TRIALS research · 2025-03-04Clinical Trial Update: A Study of XS-04 in Patients with Relapsed or Refractory Hematologic Malignancies [Phase 1]
Phase 1 study of XS-04 in relapsed or refractory hematologic malignancies, including B-cell lymphoma, acute myeloid leukemia, and myelodyspl…
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CLINICAL_TRIALS research · 2025-03-04Clinical Trial Update: Safely Delivered Targeted High-dose Irradiation Followed by Adoptive Immunotherapy with Regulatory and Conventional T Cells to Increase Potency of Hematopoietic Stem Cell Transplantation in High-risk Acute Leukemia [NA]
This clinical trial update describes testing a treatment strategy that uses targeted high-dose irradiation followed by adoptive immunotherap…
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CLINICAL_TRIALS trial_result · 2025-03-03Clinical Trial Update: A Trial of AK117 (Anti-CD47 Antibody) in Patients With Acute Myeloid Leukemia [Phase 1, Phase 2]
AK117, an anti-CD47 antibody developed by Akeso, is being evaluated in adults with acute myeloid leukemia in a Phase 1/2 trial. The study st…
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CLINICAL_TRIALS trial_result · 2025-02-28Clinical Trial Update: Gilteritinib vs Midostaurin in FLT3 Mutated Acute Myeloid Leukemia [Phase 2]
Phase 2 randomized trial comparing gilteritinib to midostaurin in FLT3-mutated acute myeloid leukemia; results have been posted.
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CLINICAL_TRIALS research · 2025-02-28Clinical Trial Update: Psychometric Properties of the Therapy-Related Symptom Checklist-Children
This clinical trial update evaluates the psychometric properties of the Therapy-Related Symptom Checklist-Children and its use in pediatric …
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CLINICAL_TRIALS research · 2025-02-28Clinical Trial Update: Relation Between Venetoclax Plasma Concentration and Remission in Adults with Acute Myeloid Leukemia (PREDICLAX)
An ongoing clinical trial is investigating whether venetoclax plasma concentration relates to remission outcomes in adults with acute myeloi…
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CLINICAL_TRIALS research · 2025-02-27Clinical Trial Update: Effectiveness of Early Intervention in Palliative Care for Acute Myeloid Leukemia Patients Comparing to Standard of Care [NA]
A Universidade do Porto-led clinical trial is evaluating whether early palliative care intervention improves outcomes for patients with acut…
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CLINICAL_TRIALS trial_result · 2025-02-26Clinical Trial Update: Study to Evaluate the Safety and Preliminary Efficacy of CLL1 and CD38 Dual CAR-T in r/r AML [EARLY_Phase 1]
Phase 1 study evaluating the safety and preliminary efficacy of CLL1 and CD38 dual CAR-T cells in relapsed/refractory acute myeloid leukemia…
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CLINICAL_TRIALS research · 2025-02-25Clinical Trial Update: PTCy and ATG for MSD and MUD Transplants [Phase 1, Phase 2]
Ongoing Phase 1/2 clinical trial evaluating post-transplant cyclophosphamide and anti-thymocyte globulin for matched sibling and matched unr…
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CLINICAL_TRIALS trial_result · 2025-02-25Clinical Trial Update: Midostaurin Associated With Standard Chemotherapy in Patients With Core-binding Factor Leukemia [Phase 2]
A Phase 2 trial evaluating midostaurin with standard chemotherapy for core-binding factor acute myeloid leukemia has been terminated.