Acute Myeloid Leukemia
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CLINICAL_TRIALS trial_result · 2025-10-14Clinical Trial Update: IDH2 Inhibition Using Enasidenib as Maintenance Therapy for IDH2-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation [Phase 1]
A Phase 1 trial evaluates enasidenib as maintenance therapy for IDH2-mutant myeloid neoplasms after allogeneic stem cell transplantation. Th…
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: Interferon-γ (IFN-γ) With Donor Leukocyte Infusion to Treat Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndromes Post Allogeneic Hematopoietic Stem Cell Transplantation [Phase 2]
Phase 2 clinical trial evaluating interferon-γ in combination with donor leukocyte infusion for relapsed acute myeloid leukemia and myelodys…
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CLINICAL_TRIALS other · 2025-10-14Clinical Trial Update: Study to Evaluate the Safety and Tolerability of EP0042 [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating the safety and tolerability of EP0042 from Ellipses Pharma is currently recruiting for acute myeloid leu…
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CLINICAL_TRIALS trial_result · 2025-10-10Clinical Trial Update: A Study of Siremadlin in Combination With Venetoclax Plus Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Chemotherapy. [Phase 1]
Phase 1 study evaluating siremadlin with venetoclax and azacitidine in adults with acute myeloid leukemia ineligible for chemotherapy has be…
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CLINICAL_TRIALS withdrawal · 2025-10-10Clinical Trial Update: HDM201 in Combination With MBG453 or Venetoclax in Patients With Acute Myeloid Leukemia (AML) or High-risk Myelodysplastic Syndrome (MDS) [Phase 1]
A Phase 1 trial investigating HDM201 in combination with MBG453 or venetoclax in patients with acute myeloid leukemia or high-risk myelodysp…
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CLINICAL_TRIALS trial_result · 2025-10-10Clinical Trial Update: VOB560-MIK665 Combination First in Human Trial in Patients With Hematological Malignancies (Relapsed/Refractory Non-Hodgkin Lymphoma, Relapsed/Refractory Acute Myeloid Leukemia, or Relapsed/Refractory Multiple Myeloma) [Phase 1]
This update reports termination of the first-in-human Phase 1 trial of the VOB560-MIK665 combination in relapsed/refractory hematologic mali…
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: Venetoclax- Augmented Treosulfan-Based Reduced Intensity Conditioning Before Allogeneic Stem Cell Transplantation [Phase 2]
Phase 2 clinical trial evaluating venetoclax-augmented treosulfan-based reduced-intensity conditioning before allogeneic stem cell transplan…
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: A Phase 1/2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Hematologic and Myeloproliferative Malignancies [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating CPI-0610 with and without ruxolitinib in patients with hematologic and myeloproliferative malignancies. …
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplant [Phase 2]
A Phase 2 clinical trial from University of Alabama at Birmingham evaluating a two-step anti-thymocyte globulin regimen to prevent acute gra…
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EMA approval · 2025-10-08EMA Authorised: Azacitidine Accord (azacitidine) — Accord Healthcare S.L.U.
EMA authorised Azacitidine Accord, a generic azacitidine product, for myelodysplastic syndromes and certain leukemias (acute myeloid leukemi…
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CLINICAL_TRIALS research · 2025-10-06Clinical Trial Update: Next Generation Sequencing (NGS) in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes
This clinical trial update concerns a Brescia-based study using next-generation sequencing to investigate familial acute myeloid leukemia an…
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CLINICAL_TRIALS trial_result · 2025-10-06Clinical Trial Update: A Study Evaluating Safety and Efficacy of Venetoclax in Combination With Azacitidine Versus Standard of Care After Allogeneic Stem Cell Transplantation (SCT) in Participants With Acute Myeloid Leukemia (AML) [Phase 3]
A Phase 3 trial comparing venetoclax plus azacitidine to standard of care after allogeneic stem cell transplantation in acute myeloid leukem…
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CLINICAL_TRIALS research · 2025-10-06Clinical Trial Update: A Phase 1B Investigator Initiated Study of Safety and Tolerability of Dexamethasone (D) in Combination With Venetoclax-based Low-Intensity Therapy (LIT) in Treatment-Naïve Acute Myeloid Leukemia (AML): DLIT-AML [Phase 1]
Phase 1B investigator-initiated study evaluating safety and tolerability of dexamethasone in combination with venetoclax-based low-intensity…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: High-Altitude Hematology Observation-Stem Cell Transplantation (HALO-SCT)
The document announces a new clinical trial called HALO-SCT, assessing high-altitude observation in stem cell transplantation. It is current…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Prospective Non-interventional Study of Adult Patients With Acute Myeloid Leukemia (AML)
Prospective non-interventional study enrolling adults with acute myeloid leukemia to observe real-world treatment patterns and outcomes.
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: AB8939 in Patients With Relapsed/Refractory Acute Myeloid Leukemia [Phase 1, Phase 2]
A Phase 1/2 clinical trial of AB8939 for relapsed or refractory acute myeloid leukemia is currently recruiting. The study also references my…
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CLINICAL_TRIALS trial_result · 2025-10-02Clinical Trial Update: Multicenter Retrospective Observatory of Patients With Acute Myeloid Leukemia to Core Binding Factor
This completed multicenter retrospective study collected data on patients with acute myeloid leukemia with core binding factor rearrangement…
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CLINICAL_TRIALS trial_result · 2025-10-01Clinical Trial Update: Galinpepimut-S Versus Investigator's Choice of Best Available Therapy for Maintenance in AML CR2/CRp2 [Phase 3]
A Phase 3 trial evaluates Galinpepimut-S as maintenance therapy versus investigator's choice of best available therapy in acute myeloid leuk…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: CD123+CLL-1 CAR-T Sequential Infusion With CD7 CAR-T and Bridging to Allo-HSCT for Relapsed/Refractory Acute Myeloid Leukemia [EARLY_Phase 1]
This early-phase clinical trial update describes sequential infusion of CD123+CLL-1 CAR-T cells with a CD7 CAR-T and bridging to allogeneic …
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CLINICAL_TRIALS trial_result · 2025-10-01Clinical Trial Update: A Study of JNJ-74856665 in Participants With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) [Phase 1]
Phase 1 study of JNJ-74856665 in participants with Acute Myeloid Leukemia, Myelodysplastic Syndromes, or Chronic Myelomonocytic Leukemia has…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: The Efficacy of Triple Regimen in Newly Diagnosed AML Patients With FLT3 Mutation [Phase 1, Phase 2]
A Phase 1/Phase 2 study is evaluating a triple regimen for newly diagnosed acute myeloid leukemia with FLT3 mutation. Recruitment is ongoing…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: A Phase 1 Study of WU-NK-101 in Patients With Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) [Phase 1]
The Phase 1 study of WU-NK-101 in relapsed or refractory acute myeloid leukemia has completed.
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Study of MP0533 in Patients Acute Myeloid Leukemia or Myelodysplastic Syndrome [Phase 1, Phase 2]
MP0533 is being studied in patients with acute myeloid leukemia or myelodysplastic syndrome in a Phase 1/2 trial that is currently recruitin…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: CLL-1 CAR-NK Cells for Relapsed/Refractory AML [Phase 1]
This clinical trial update reports a Phase 1 study evaluating CAR-NK cells targeting CLL-1 for relapsed or refractory acute myeloid leukemia…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: A Study of A-CAR028 Treatment in Subjects With Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]
A-CAR028 is being studied in a Phase 1 trial for relapsed or refractory acute myeloid leukemia and the study is currently recruiting. The do…