Acute Myeloid Leukemia
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CLINICAL_TRIALS trial_result · 2026-01-05Clinical Trial Update: A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT [Phase 1]
Phase 1 trial evaluating a combination of CD25/Treg-depleted donor lymphocyte infusion with ipilimumab for relapse of myeloid diseases after…
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CLINICAL_TRIALS trial_result · 2026-01-05Clinical Trial Update: A Study of Gilteritinib (ASP2215) Combined With Chemotherapy in Children, Adolescents and Young Adults With FMS-like Tyrosine Kinase 3 (FLT3)/Internal Tandem Duplication (ITD) Positive Relapsed or Refractory Acute Myeloid Leukemia (AML) [Phase 1, Phase 2]
A Phase 1/2 study evaluating gilteritinib in combination with chemotherapy for pediatric and young adult FLT3-ITD–positive relapsed/refracto…
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CLINICAL_TRIALS research · 2026-01-05Clinical Trial Update: A Phase 2 Study of Gemtuzumab Ozogamicin (GO)-Gilteritinib Combination in Adults With FLT3-ITD and/or FLT3-TKD Relapse/Refractory (R/R) AML [Phase 2]
Phase 2 study evaluating the combination of gemtuzumab ozogamicin and gilteritinib in adults with relapsed/refractory FLT3-mutant acute myel…
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CLINICAL_TRIALS research · 2026-01-05Clinical Trial Update: High-Intensity Parent Intervention Program in Improving Learning and School Functioning in Latino Children With Acute Leukemia or Lymphoblastic Lymphoma [NA]
This clinical trial update describes a non-pharmacologic High-Intensity Parent Intervention Program aimed at improving learning and school f…
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CLINICAL_TRIALS research · 2026-01-05Clinical Trial Update: Registry Study on Patient Characteristics, Biological Disease Profile and Clinical Outcome in Acute Myeloid Leukemia and Related Neoplasms - The Biology and Outcome (BiO)-Project
A registry-based study (Biology and Outcome Project) enrolling patients with acute myeloid leukemia and myelodysplastic syndromes/AML to cha…
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CLINICAL_TRIALS trial_result · 2026-01-02Clinical Trial Update: Efficiency of Antibacterial Prophylaxis in Azacitidine Treated Patients [Phase 3]
Phase 3 trial evaluating antibacterial prophylaxis in azacitidine-treated patients has completed.
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation [Phase 1]
Phase 1 clinical trial evaluating preemptive CIML NK cell therapy after hematopoietic stem cell transplantation in patients with acute myelo…
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: Evaluate the Safety, Tolerability, Pharmacokinetic Profile, Efficacy of Bl-M11D1 [Phase 1]
Phase 1 clinical trial evaluating the safety, tolerability, pharmacokinetics, and preliminary efficacy of Bl-M11D1 in patients with relapsed…
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: Using Multiparametric Flow Cytometry to Detect Peripheral Blood and Bone Marrow Leukaemia Stem Cells for Relapse Prediction in P-AML
Recruiting study evaluating multiparametric flow cytometry to detect leukemia stem cells in peripheral blood and bone marrow to predict rela…
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: Dose Escalation and Expansion Study to Evaluate the Safety, PK, PD and Efficacy of ZE46-0134 in Adults With FLT3 Mutated or Spliceosome Mutated Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]
A Phase 1 dose-escalation and expansion study is evaluating ZE46-0134 in adults with FLT3-mutated or spliceosome-mutated relapsed/refractory…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Safety and Feasibility of Sulforaphane to Promote Early Haematopoietic Recovery After Cord Blood Transplantation [NA]
A clinical trial is evaluating the safety and feasibility of sulforaphane to promote early hematopoietic recovery after cord blood transplan…
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: CAV Regimen for R/R AML [Phase 2]
A Phase 2 clinical trial evaluating the CAV regimen for relapsed/refractory acute myeloid leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: A Study to Assess Adverse Events and How Intravenous (IV) Pivekimab Sunirine Moves Through the Body in Pediatric Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML) [Phase 1]
Phase 1 study to evaluate adverse events and pharmacokinetics of intravenously delivered pivekimab sunirine in pediatric patients with relap…
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: Post-transplantation Maintenance Therapy With Cidabenamide in Patients With Intermediate/High-risk AML [Phase 2]
A Phase 2 trial is evaluating cidabenamide as maintenance therapy after allogeneic hematopoietic cell transplantation in patients with inter…
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CLINICAL_TRIALS trial_result · 2025-12-26Clinical Trial Update: A Phase 1b Study of Lonitoclax + Azacitidine in Acute Myeloid Leukemia Patients [Phase 1]
This document announces a Phase 1b trial of Lonitoclax in combination with azacitidine for Acute Myeloid Leukemia, and the study is currentl…
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CLINICAL_TRIALS trial_result · 2025-12-26Clinical Trial Update: Clinical Study of CWP232291 in Acute Myeloid Leukemia Patients [Phase 1, Phase 2]
The Phase 1/2 clinical study of CWP232291 in Acute Myeloid Leukemia has been terminated.
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CLINICAL_TRIALS trial_result · 2025-12-24Clinical Trial Update: Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN [Phase 1]
This Phase 1 trial update reports adding venetoclax to fludarabine and busulfan conditioning before transplant and to maintenance therapy fo…
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: Cytokine Induced Memory-like NK Cell Adoptive Therapy After Haploidentical Donor Hematopoietic Cell Transplantation [Phase 2]
Phase 2 trial of cytokine-induced memory-like NK cell adoptive therapy after haploidentical donor stem cell transplantation for acute myeloi…
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CLINICAL_TRIALS trial_result · 2025-12-23Clinical Trial Update: CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old [Phase 2]
Phase 2 trial update of CPX-351 for secondary acute myeloid leukemia in patients under 60; the study is currently active but not recruiting,…
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CLINICAL_TRIALS research · 2025-12-23Clinical Trial Update: PLAT-08: A Study Of SC-DARIC33 CAR T Cells In Pediatric And Young Adults With Relapsed Or Refractory CD33+ AML [Phase 1]
A Phase 1 study evaluating SC-DARIC33 CAR T cells in pediatric and young adult patients with relapsed or refractory CD33-positive acute myel…
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CLINICAL_TRIALS trial_result · 2025-12-23Clinical Trial Update: Minimal Residual Disease Evaluation on Cryopreserved Ovarian Fragments in Younger Patients Treated for Acute Myeloid Leukemia
This completed clinical trial evaluated minimal residual disease in cryopreserved ovarian tissue from younger patients treated for acute mye…
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CLINICAL_TRIALS trial_result · 2025-12-22Clinical Trial Update: GEN3014 Trial in Relapsed or Refractory Hematologic Malignancies [Phase 1, Phase 2]
Genmab's GEN3014 trial in relapsed or refractory hematologic malignancies (relapsed/refractory multiple myeloma, diffuse large B cell lympho…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome [Phase 3]
A Phase 3 clinical trial comparing mismatched related donor versus matched unrelated donor stem cell transplantation in children, adolescent…
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes [Phase 2]
Phase 2 trial evaluating adding pomalidomide to the standard liposomal daunorubicin/cytarabine chemotherapy in newly diagnosed acute myeloid…
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: Off-the-shelf NK Cells + SCT for Myeloid Malignancies [Phase 2]
Phase 2 trial evaluating off-the-shelf natural killer (NK) cells in combination with stem cell transplantation for myeloid malignancies has …