Acute Lymphoblastic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2018-04-20Clinical Trial Update: Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid [Phase 4]
A Phase 4 trial is comparing two formulations of 6-mercaptopurine (tablet versus oral liquid) for acute lymphoblastic leukemia; the current …
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CLINICAL_TRIALS trial_result · 2018-04-11Clinical Trial Update: Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma [Phase 1]
Phase 1 study evaluating alisertib in combination with vorinostat in adults with relapsed or recurrent Hodgkin lymphoma, B-cell non-Hodgkin …
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CLINICAL_TRIALS research · 2018-04-11Clinical Trial Update: Refining and Testing the Diagnostic Accuracy of PAT-POPS
An update on a clinical trial evaluating the diagnostic accuracy of PAT-POPS for acute lymphoblastic leukemia in pediatric patients.
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CLINICAL_TRIALS trial_result · 2018-04-10Clinical Trial Update: Phase 2 Haplotype Mismatched HSCT in Patients With Hematological Malignancies [Phase 2]
A Phase 2 trial evaluated haplotype-mismatched hematopoietic stem cell transplantation in patients with hematological malignancies. The stud…
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CLINICAL_TRIALS trial_result · 2018-03-22Clinical Trial Update: D-ALBA Frontline Sequential Dasatinib and Blinatumomab in Adult Philadelphia Positive Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical trial update evaluating frontline sequential dasatinib followed by blinatumomab in adults with Philadelphia chromosome-posi…
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FDA approval · 2018-03-15FDA Approved: METHOTREXATE — Supplemental Application (Hospira, Inc.)
FDA approved a supplemental application for Methotrexate submitted by Hospira, Inc.
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CLINICAL_TRIALS withdrawal · 2018-03-14Clinical Trial Update: Pharmacokinetic and Pharmacodynamic Assessment of Treatment With CPX-351 (Cytarabine: Daunorubicin) Liposome for Injection in Acute Leukemias and MDS Patients With Moderate Hepatic Impairment [Phase 2]
Clinical trial update notes that a Phase 2 study evaluating the pharmacokinetics and pharmacodynamics of CPX-351 in acute leukemias and myel…
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CLINICAL_TRIALS trial_result · 2018-03-13Clinical Trial Update: De-escalated Treatment Approach for Adult Ph-negative Acute Lymphoblastic Leukemia (ALL) [NA]
This clinical trial update discusses a de-escalated treatment approach being studied in adults with Ph-negative acute lymphoblastic leukemia…
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CLINICAL_TRIALS trial_result · 2018-02-22Clinical Trial Update: Study of Fc-Optimized Anti-CD19 Antibody (MOR00208) to Treat B-cell Acute Lymphoblastic Leukemia(B-ALL) [Phase 2]
Phase 2 study of Fc-optimized anti-CD19 antibody MOR00208 for B-cell acute lymphoblastic leukemia has been terminated; results posted in 201…
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CLINICAL_TRIALS trial_result · 2018-02-01Clinical Trial Update: Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic Malignancies [Phase 2]
Phase 2 trial of bortezomib plus vorinostat in younger patients with MLL-rearranged hematologic malignancies was terminated; results were po…
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CLINICAL_TRIALS trial_result · 2018-01-23Clinical Trial Update: Safety & Efficacy of Atorvastatin for Prophylaxis of Acute Graft Versus Host Disease in Patients With Hematological Malignancies HLA- Donor Hematopoietic Stem Cell Transplantation [Phase 2]
Phase 2 trial evaluating atorvastatin for prophylaxis of acute graft-versus-host disease in patients undergoing HLA-mon donor hematopoietic …
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CLINICAL_TRIALS trial_result · 2018-01-17Clinical Trial Update: A Study Of Inotuzumab Ozogamicin Versus Investigator's Choice Of Chemotherapy In Patients With Relapsed Or Refractory Acute Lymphoblastic Leukemia [Phase 3]
Phase 3 trial comparing inotuzumab ozogamicin to investigator's choice chemotherapy in relapsed/refractory acute lymphoblastic leukemia has …
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CLINICAL_TRIALS trial_result · 2018-01-16Clinical Trial Update: Post-transplantation Cyclophosphamide as GVHD Prophylaxis After HSCT [Phase 2]
Phase 2 trial evaluating post-transplant cyclophosphamide as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell …
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CLINICAL_TRIALS trial_result · 2017-12-08Clinical Trial Update: Rasburicase and Allopurinol in Treating Patients With Hematologic Malignancies [Phase 2]
Phase 2 trial evaluating rasburicase and allopurinol in adults with hematologic malignancies; the study was terminated with results posted i…
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CLINICAL_TRIALS research · 2017-12-06Clinical Trial Update: Antiminor Histocompatibility Complex (MiHA) T Cells for Patients With Relapsed Hematologic Malignancies Following Matched HSCT (Guided Lymphocyte Immunopeptide Derived Expansion) [Phase 1, Phase 2]
Phase 1/2 study investigating Antiminor Histocompatibility Complex (MiHA) T cells in patients with relapsed hematologic malignancies after m…
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CLINICAL_TRIALS withdrawal · 2017-12-05Clinical Trial Update: StemRegenin-1 Expanded vs Unexpanded UCB for High Risk Heme Malignancies [Phase 2]
Phase 2 trial evaluating StemRegenin-1-expanded versus unexpanded umbilical cord blood for high-risk hematologic malignancies has been withd…
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CLINICAL_TRIALS trial_result · 2017-12-05Clinical Trial Update: Total Marrow Irradiation for Refractory Acute Leukemia [Phase 1]
A Phase 1 trial evaluating total marrow irradiation for refractory acute leukemia has completed enrollment/status; the study included patien…
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CLINICAL_TRIALS trial_result · 2017-12-05Clinical Trial Update: AHN-12 Biodistribution in Advanced Leukemia [Phase 1]
A Phase 1 trial of the investigational agent AHN-12 focusing on biodistribution in advanced leukemia has been terminated.
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CLINICAL_TRIALS trial_result · 2017-12-04Clinical Trial Update: Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant [Phase 3]
Phase 3 trial update on graft-versus-host disease prophylaxis in patients with hematologic malignancies undergoing unrelated donor periphera…
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CLINICAL_TRIALS withdrawal · 2017-12-02Clinical Trial Update: T-Regulatory Cell and CD3 Depleted Double Umbilical Cord Blood Transplantation in Hematologic Malignancies [Phase 1, Phase 2]
A trial investigating T-regulatory cell and CD3-depleted double umbilical cord blood transplantation for hematologic malignancies has been w…
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CLINICAL_TRIALS withdrawal · 2017-12-02Clinical Trial Update: Clofarabine, Cyclophosphamide and Etoposide for Minimal Residual Disease Positive Acute Leukemia [Phase 2]
Phase 2 trial evaluating clofarabine, cyclophosphamide, and etoposide for minimal residual disease-positive acute leukemia has been withdraw…
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CLINICAL_TRIALS trial_result · 2017-11-30Clinical Trial Update: An Open Label Phase II Pharmacokinetic and Pharmacodynamic Assessment of the Potential for QTc Prolongation Following First Induction Treatment With CPX-351 (Cytarabine:Daunorubicin) Liposome Injection in Acute Leukemias and MDS Patients [Phase 2]
This Phase 2 open-label pharmacokinetic/pharmacodynamic trial evaluated CPX-351 (cytarabine:daunorubicin liposome injection) for potential Q…
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CLINICAL_TRIALS trial_result · 2017-11-29Clinical Trial Update: Donor Lymphocyte Infusion (DLI) for Relapsed (Post Transplant) Leukemia [NA]
The document reports the completion of a clinical trial evaluating donor lymphocyte infusion for relapsed leukemia after transplantation acr…
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CLINICAL_TRIALS trial_result · 2017-11-29Clinical Trial Update: Yttrium Y 90 Anti-CD19 Antibody BU-12 in Patients With Advanced Relapsed or Refractory Acute Lymphoblastic Leukemia or Chronic Lymphocytic Leukemia [Phase 1]
Phase 1 trial of BU-12, a Yttrium-90 labeled anti-CD19 antibody, in advanced relapsed or refractory acute lymphoblastic leukemia or chronic …
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CLINICAL_TRIALS trial_result · 2017-11-20Clinical Trial Update: ABT-348 as Monotherapy and in Combination With Azacitidine to Treat Advanced Hematologic Malignancies [Phase 1]
A Phase 1 trial evaluated ABT-348 as a standalone therapy and in combination with azacitidine for advanced hematologic malignancies; the stu…