Acute Lymphoblastic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS withdrawal · 2026-02-24Clinical Trial Update: Cryopreserved MMUD BM With PTCy for Hematologic Malignancies [Phase 1]
Phase 1 trial of cryopreserved MMUD bone marrow with post-transplant cyclophosphamide for hematologic malignancies has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2026-02-18Clinical Trial Update: SPARK-ALL: Calaspargase Pegol in Adults With ALL [Phase 2, Phase 3]
Clinical trial SPARK-ALL evaluating Calaspargase Pegol in adults with acute lymphoblastic leukemia was terminated (Phase 2/3).
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CLINICAL_TRIALS withdrawal · 2026-01-23Clinical Trial Update: Erwinase Master Treatment Protocol
This update notes that the Erwinase master treatment protocol for acute lymphoblastic leukemia is no longer available.
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CLINICAL_TRIALS withdrawal · 2025-07-14Clinical Trial Update: TCRαβ/CD19 Depletion of Stem Cell Grafts for Transplant [NA]
A clinical trial evaluating TCRαβ/CD19-depleted stem cell grafts for transplantation has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2025-07-04Clinical Trial Update: Difficult PIV Placement in the Pediatric ED [NA]
The clinical trial NCT06013904 evaluating difficult peripheral IV placement in pediatric ALL patients has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2025-07-03Clinical Trial Update: Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL [Phase 1]
The Phase 1 study of BMF-219, Biomea Fusion's covalent menin inhibitor, in adults with AML, ALL, DLBCL, multiple myeloma, and CLL/SLL has be…
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CLINICAL_TRIALS withdrawal · 2025-06-22Clinical Trial Update: A Study of JNJ-75276617 in Combination With Conventional Chemotherapy for Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias [Phase 1]
A Phase 1 trial of JNJ-75276617 in combination with conventional chemotherapy for pediatric and young adult patients with relapsed/refractor…
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CLINICAL_TRIALS withdrawal · 2025-02-03Clinical Trial Update: Expanded Access Program of Venetoclax and Navitoclax for Pediatric Patients with Relapsed or Refractory ALL or LL
Expanded access program for venetoclax and navitoclax in pediatric relapsed/refractory acute lymphoblastic leukemia or lymphoblastic lymphom…
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CLINICAL_TRIALS withdrawal · 2024-12-05Clinical Trial Update: Preemptive Infusion of Donor Lymphocytes Depleted of TCR + T Cells + CD19+ B Cells Following ASCT [Phase 1]
A Phase 1 trial evaluating a preemptive infusion of donor lymphocytes depleted of TCR+ T cells and CD19+ B cells after autologous stem cell …
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CLINICAL_TRIALS withdrawal · 2024-09-25Clinical Trial Update: Continuous Ambulatory Monitoring to Predict Elevated Risk of Infection in Children With Lymphoblastic Leukemia Undergoing Induction Chemotherapy (CAMPER-ALL)
A clinical trial investigating continuous ambulatory monitoring to predict infection risk in children with Acute Lymphoblastic Leukemia unde…
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CLINICAL_TRIALS withdrawal · 2024-08-26Clinical Trial Update: Taking POSNA's OrthoKids to the People [NA]
Clinical trial NCT04996745 has been withdrawn; the study involved pediatric forearm fracture and pediatric acute lymphoblastic leukemia unde…
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CLINICAL_TRIALS withdrawal · 2024-08-14Clinical Trial Update: Ponatinib Plus Reduced-intensity Chemotherapy in the First-line Treatment of Adult Patients With Ph+ ALL [Phase 2]
A Phase 2 trial evaluating ponatinib plus reduced-intensity chemotherapy as first-line therapy for adults with Philadelphia chromosome-posit…
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CLINICAL_TRIALS withdrawal · 2024-06-21Clinical Trial Update: HEM-iSMART-A: Decitabine / Venetoclax and Navitoclax in Pediatric Patients With Relapsed or Refractory Hematological Malignancies [Phase 1, Phase 2]
Clinical trial update notes the withdrawal of a Phase 1/2 study evaluating decitabine with venetoclax and navitoclax for relapsed or refract…
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CLINICAL_TRIALS withdrawal · 2021-04-27Clinical Trial Update: Randomized Study: Standard of Care With or Without Atorvastatin for Prevention of GVHD for Matched Unrelated Donor BMT [Phase 3]
Phase 3 randomized trial evaluating standard of care with or without atorvastatin for prevention of graft-versus-host disease in matched unr…
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CLINICAL_TRIALS withdrawal · 2020-07-09Clinical Trial Update: Tisagenlecleucel vs Blinatumomab or Inotuzumab for Patients With Relapsed/Refractory B-cell Precursor Acute Lymphoblastic Leukemia [Phase 3]
Phase 3 trial comparing tisagenlecleucel against blinatumomab or inotuzumab for relapsed/refractory B-cell precursor ALL has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2018-07-26Clinical Trial Update: Trial Evaluating the Efficacy and Safety of Daratumumab in Subjects With Relapsed/Refractory B-cell or T-cell Precursor Acute Lymphoblastic Leukemia (ALL) [Phase 2]
A Phase 2 trial evaluating daratumumab for relapsed/refractory B-cell or T-cell precursor acute lymphoblastic leukemia has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2018-03-14Clinical Trial Update: Pharmacokinetic and Pharmacodynamic Assessment of Treatment With CPX-351 (Cytarabine: Daunorubicin) Liposome for Injection in Acute Leukemias and MDS Patients With Moderate Hepatic Impairment [Phase 2]
Clinical trial update notes that a Phase 2 study evaluating the pharmacokinetics and pharmacodynamics of CPX-351 in acute leukemias and myel…
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CLINICAL_TRIALS withdrawal · 2017-12-05Clinical Trial Update: StemRegenin-1 Expanded vs Unexpanded UCB for High Risk Heme Malignancies [Phase 2]
Phase 2 trial evaluating StemRegenin-1-expanded versus unexpanded umbilical cord blood for high-risk hematologic malignancies has been withd…
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CLINICAL_TRIALS withdrawal · 2017-12-02Clinical Trial Update: T-Regulatory Cell and CD3 Depleted Double Umbilical Cord Blood Transplantation in Hematologic Malignancies [Phase 1, Phase 2]
A trial investigating T-regulatory cell and CD3-depleted double umbilical cord blood transplantation for hematologic malignancies has been w…
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CLINICAL_TRIALS withdrawal · 2017-12-02Clinical Trial Update: Clofarabine, Cyclophosphamide and Etoposide for Minimal Residual Disease Positive Acute Leukemia [Phase 2]
Phase 2 trial evaluating clofarabine, cyclophosphamide, and etoposide for minimal residual disease-positive acute leukemia has been withdraw…
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CLINICAL_TRIALS withdrawal · 2017-07-26Clinical Trial Update: Comparing CGM and OGTT in Relation to Iron Overload Detected by Pancreas T2* MRI in High-Risk Hematology Group
A clinical trial comparing continuous glucose monitoring (CGM) and oral glucose tolerance testing (OGTT) in relation to pancreas T2* MRI-det…
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CLINICAL_TRIALS withdrawal · 2017-06-02Clinical Trial Update: Intravenous Erwinia Chrysanthemi Asparaginase in Patients With Newly Diagnosed Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Aged 60 Years or Older [Phase 1]
A Phase 1 trial of intravenous Erwinia chrysanthemi asparaginase in newly diagnosed Philadelphia chromosome-negative acute lymphoblastic leu…
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CLINICAL_TRIALS withdrawal · 2017-01-19Clinical Trial Update: Testing a Reduced Conditioning Regimen FB2A2 Preceded by a Fractionated Radio-immunotherapy (RIT) With 90Y-Epratuzumab Before Allogeneic Stem Cell Transplantation for Patients With Lymphocyte B CD22 Positive Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
This clinical trial update reports withdrawal of a Phase 1/2 study evaluating a reduced conditioning regimen with 90Y-epratuzumab radioimmun…
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CLINICAL_TRIALS withdrawal · 2016-12-15Clinical Trial Update: Volasertib and Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia [Phase 1]
A Phase 1 trial combining volasertib with vincristine sulfate liposome for relapsed or refractory adult acute lymphoblastic leukemia was wit…
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CLINICAL_TRIALS withdrawal · 2016-07-14Clinical Trial Update: Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies [Phase 2]
A Phase 2 clinical trial evaluating single or double donor umbilical cord blood transplant for high-risk hematologic malignancies has been w…