Acute Lymphoblastic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Pharmacogenomics of Asparaginase Induced Hepatotoxicity
A clinical trial update describes ongoing pharmacogenomic research into factors that influence asparaginase-induced hepatotoxicity in acute …
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors [Phase 2]
Phase 2 study evaluating exercise training with nicotinamide riboside (NR) supplementation to improve fitness in adolescent/young adult hema…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: CD19-CD22-Bispecific Chimeric Antigen Receptor (CAR) T Cell Therapy for Pediatric Patients With Acute Lymphoblastic Leukemia [Phase 1]
This clinical trial update reports on a Phase 1 study of a CD19-CD22 bispecific CAR-T cell therapy for pediatric acute lymphoblastic leukemi…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Evaluation of the Efficacy of a Virtual Reality When Placing a Needle on an Implantable Venous Access Device in Children With Leukemia [NA]
A clinical trial is evaluating whether virtual reality can reduce anxiety and discomfort during needle placement for implantable venous acce…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: A Multicenter Study of CAR-T Cells in Primary Ph+All [Phase 2]
A multicenter Phase 2 clinical trial evaluating CAR-T cell therapy for Philadelphia chromosome-positive acute lymphoblastic leukemia is curr…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Virtual Reality-Infused Treadmill Training on Aging-Related Outcomes [NA]
A recruiting clinical trial sponsored by The University of Texas at Arlington is evaluating virtual reality–infused treadmill training and i…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Efficacy of Dose-Adjusted Regimen on Survival in Frail Adults With Acute Lymphoblastic Leukemia
This update describes a clinical trial evaluating a dose-adjusted regimen for frail adults withacute lymphoblastic leukemia. It aims to asse…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: CD19-CAR_Lenti T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ ALL and DLBCL or PML [Phase 1, Phase 2]
This clinical trial update describes pediatric patients with relapsed/refractory CD19+ acute lymphoblastic leukemia and diffuse large B-cell…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML [Phase 1]
A Phase I study of the selective nuclear export inhibitor KPT-330 (selinexor) in children with relapsed or refractory acute lymphoblastic le…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: A Multicenter, Open-Label, Non-Randomized, Single-Arm Clinical Study of Nanobody CD5-CAR T Cell Therapy for Refractory/Relapsed T Lymphocyte Malignancies [Phase 1, Phase 2]
A multicenter Phase 1/2 open-label, single-arm study evaluating nanobody-based CD5-CAR T cell therapy for relapsed/refractory T-cell maligna…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Autologous and Donor-derived CD7 CAR-T Therapy in Refractory or Relapsed T-cell Malignancies [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating autologous and donor-derived CD7 CAR-T cell therapy for refractory or relapsed T-cell malignancies,…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: A Multi-center Retrospective Study of INO Treating B-ALL
A multi-center retrospective study evaluating Inotuzumab Ozogamicin for B-cell acute lymphoblastic leukemia, with Venetoclax as part of the …
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Study of the Medullary Microenvironment in Acute Childhood Leukemia [NA]
A pediatric clinical trial is investigating the medullary microenvironment in acute lymphoblastic leukemia and acute myeloid leukemia; the s…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise
A clinical trial update describing a study to assess how exercise affects fitness and lung function in survivors of heart transplant, acute …
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: VR-PAT and fNIRS to Identify CNS Biomarkers of Pain [NA]
This clinical trial update describes using VR-PAT and fNIRS to identify CNS biomarkers of pain in pediatric patients, with conditions includ…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Inotuzumab Ozogamicin in the Treatment of MRD+ After HSCT of ALL [Phase 2]
Phase 2 clinical trial investigating inotuzumab ozogamicin for patients with acute lymphoblastic leukemia who remain MRD-positive after hema…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Ribociclib in Combination With Everolimus and Dexamethasone in Relapsed ALL [Phase 1]
A Phase 1 clinical trial update evaluating the combination of ribociclib, everolimus, and dexamethasone for relapsed acute lymphoblastic leu…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant [Phase 1]
This clinical trial update describes a Phase 1 study evaluating HA-1 TCR T-cell immunotherapy for relapsed or refractory acute leukemia afte…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: Trivalent CAR-T Cell in Acute B-Lineage Leukemia (TRICAR-ALL) [Phase 1]
A Phase 1 trial evaluating a trivalent CAR-T cell therapy for acute B-lineage leukemia is currently recruiting (TRICAR-ALL).
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: ALL Backbone in AYAs [Phase 2]
Phase 2 clinical trial evaluating the ALL Backbone regimen in adolescents and young adults with acute lymphoblastic leukemia; the study is c…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia [EARLY_Phase 1]
This early-phase clinical trial evaluates the safety and feasibility of combining allogeneic CMV-specific CD19-CAR T cells with the CMV-MVA …
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome [Phase 1]
Phase 1 clinical trial update on Orca-T after chemotherapy and total marrow and lymphoid irradiation for acute myeloid leukemia, acute lymph…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: huCART19-IL18 in CD19+ Cancers [Phase 1]
Phase 1 clinical trial of huCART19-IL18 for CD19+ cancers is currently ACTIVE_NOT_RECRUITING, sponsored by the University of Pennsylvania, i…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Personalized NK Cell Therapy in CBT [Phase 2]
A Phase 2 trial from MD Anderson is evaluating personalized NK cell therapy across several hematologic cancers. The study is currently recru…
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome [Phase 2]
A Phase 2 trial evaluating ruxolitinib with tacrolimus and methotrexate to prevent graft-versus-host disease in pediatric and young adult pa…