Acute Lymphoblastic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Fourth-gen CAR T Cells Targeting CD19/CD22 for Highly Resistant B-cell Lymphoma/Leukemia (PMBCL/CNS-BCL). [Phase 1, Phase 2]
This Clinical Trial Update describes a fourth-generation CD19/CD22 dual-targeting CAR T-cell therapy being evaluated in Phase 1/2 for highly…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: ABO and Rh Blood Group Frequencies in Acute Leukemia Patients
A clinical trial conducted by Assiut University is investigating the frequencies of ABO and Rh blood groups in patients with acute leukemia …
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: Multicenter HomeVENT: Home Values and Experiences Navigation Track [NA]
A multicenter clinical trial sponsored by Johns Hopkins University is currently recruiting for the HomeVENT program’s Home Values and Experi…
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: Pediatric-inspired Regimen Combined With Venetoclax for Adolescent and Adult Patients With de Novo Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical trial evaluating a pediatric-inspired regimen in combination with venetoclax for adolescents and adults with de novo Philad…
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CLINICAL_TRIALS research · 2025-07-28Clinical Trial Update: Ex Vivo T-Cell-Depleted Haploidentical Transplantation Bridging With Chimeric Antigen Receptor T-cell Therapy and Prophylactic Memory T Cell Infusion for Acute Leukemia [NA]
This document provides a clinical trial update describing a novel transplantation approach for acute leukemia that combines ex vivo T-cell–d…
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: Reduced ATG Plus Mini PTCy for GVHD Prophylaxis in Haplo-SCT [Phase 2]
Phase 2 trial evaluating reduced ATG plus mini post-transplant cyclophosphamide for graft-versus-host disease prophylaxis in haploidentical …
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: A Phase 1 Study of FIT-CD19-CAR-T Cells in R/R B-ALL [Phase 1]
Phase 1 study evaluating FIT-CD19-CAR-T Cells for relapsed/refractory B-cell acute lymphoblastic leukemia is currently recruiting.
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: InterNatIonal CHildhood Leukemia Microbiome/MEtabolome Cohort
A multinational clinical trial update from Columbia University assessing the microbiome and metabolome in childhood acute lymphoblastic leuk…
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CLINICAL_TRIALS research · 2025-07-20Clinical Trial Update: Femoral Arterial Cannulation in Pediatrics [NA]
A pediatric femoral arterial cannulation trial sponsored by American University of Beirut Medical Center is currently recruiting participant…
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CLINICAL_TRIALS research · 2025-07-18Clinical Trial Update: CD19 CAR-T Cell Infusion as Consolidation Therapy in Adolescent and Adult Patients With Acute B-ALL Ineligible for Allogeneic HSCT: A Clinical Study [Phase 1, Phase 2]
This clinical trial investigates CD19 CAR-T cell infusion as consolidation therapy for adolescents and adults with acute lymphoblastic leuke…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Administration of Donor T Cells With the Caspase-9 Suicide Gene [Phase 1]
A Phase 1 trial evaluating donor T cells engineered with a caspase-9 suicide gene to enable controlled safety in hematologic diseases.
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling [Phase 1]
Phase 1 clinical trial evaluating ex vivo drug sensitivity testing and multi-omics profiling in pediatric cancers. Recruitment is ongoing ac…
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: Multicenter Study of Combined Chemotherapy and Transplantation for Adult ALL [Phase 2, Phase 3]
A multicenter Phase 2/3 clinical trial evaluating combined chemotherapy and transplantation for adult acute lymphoblastic leukemia is curren…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: Multi-virus CTLs Expressing CD19 Chimeric Receptors, CD19 Positive Malignancies Post SCT, MULTIPRAT [Phase 1]
Phase 1 trial evaluating multi-virus cytotoxic T lymphocytes engineered with CD19 chimeric receptors for CD19-positive malignancies after st…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: 90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome [Phase 1]
Phase 1 clinical trial of a radiolabeled anti-CD25 antibody with fludarabine, melphalan, and total marrow and lymphoid irradiation for high-…
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: Adding Ruxolitinib to a Combination of Dasatinib Plus Dexamethasone in Remission Induction Therapy in Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Patients Aged 40 Years or Older [Phase 1]
This clinical trial update describes adding ruxolitinib to a dasatinib plus dexamethasone induction regimen for newly diagnosed Philadelphia…
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CLINICAL_TRIALS research · 2025-07-01Clinical Trial Update: Allo HSCT Using RIC and PTCy for Hematological Diseases [Phase 2]
Phase 2 clinical trial evaluating allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning and post-transplan…
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CLINICAL_TRIALS research · 2025-07-01Clinical Trial Update: Investigation of Remimazolam in Children Undergoing Sedation for Medical Procedures [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial update assessing remimazolam for sedation in children undergoing medical procedures, sponsored by Acacia Ph…
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CLINICAL_TRIALS research · 2025-06-29Clinical Trial Update: Online Physical Activity and Health Counseling for Survivors of Childhood Acute Lymphoblastic Leukemia [NA]
A clinical trial update describes an online physical activity program and health counseling for survivors of childhood acute lymphoblastic l…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning [Phase 2]
Phase 2 trial evaluating vedolizumab with post-transplant cyclophosphamide and tacrolimus to prevent graft-versus-host disease in patients u…
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CLINICAL_TRIALS research · 2025-06-25Clinical Trial Update: BCOR and ZC3H12 Genes Knock-out CD19-targeting CAR-T Cell Therapy in r/r B-ALL [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating a CD19-targeting CAR-T cell therapy with BCOR and ZC3H12 gene knock-out for relapsed/refractory B-c…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders [Phase 2]
Phase 2 clinical trial evaluating myeloablative allogeneic hematopoietic stem cell transplantation from related or unrelated donors for a br…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: The Safety and Efficay Investigation of CAR-T Cell Therapy for Patients With Hematological Malignancies [NA]
A clinical trial is recruiting to evaluate an investigational CAR-T cell therapy for hematologic malignancies, including acute lymphoblastic…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: The Effect of Non-pharmacological Methods on Pain, Fear [NA]
A clinical trial update describing a study of non-pharmacological methods to reduce pain and fear in children, including those with pediatri…
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: Study of Nutrition and Exercise in Adults Hospitalized for Treatment of Acute Lymphoblastic Leukemia (ALL) [NA]
Clinical trial update for a nutrition and exercise program in adults undergoing treatment for acute lymphoblastic leukemia (ALL); the study …