Xerostomia
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: A Mouth Education Program for Dry Mouth [NA]
This entry reports the completion of a clinical trial evaluating a mouth education program designed to help manage dry mouth (xerostomia) in…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Sialendoscopy Versus Photobiomodulation in Prevention of Radiation Induced Xerostomia [NA]
A clinical trial is comparing sialendoscopy versus photobiomodulation to prevent radiation-induced xerostomia and is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: The Impact of Oral Health in HIV Patients on Antiretroviral Therapy
This clinical trial update reports on a completed study examining the impact of oral health on people with HIV on antiretroviral therapy. Th…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis [NA]
This clinical trial entry evaluates a whitening agent formulated as an emulsion gel for effects on saliva and halitosis; the study is curren…
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FDA approval · 2026-03-11FDA Approved: CEVIMELINE HYDROCHLORIDE — Original Application (Zydus Lifesciences Limited)
FDA approves cevimeline hydrochloride as an original ANDA submission from Zydus Lifesciences Limited.
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia [Phase 1]
This entry reports a Phase 1 dose-escalation trial of mesenchymal stromal cells for medical xerostomia, including patients with graft-versus…
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CLINICAL_TRIALS trial_result · 2026-02-10Clinical Trial Update: Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine [Phase 3]
A Phase 3 clinical trial is comparing two arginine-containing toothpastes for xerostomia, with the study currently listed as active but not …
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: Study Transplanting Bone Marrow Cells Into Salivary Glands to Treat Dry Mouth Caused by Radiation Therapy [Phase 1]
This clinical trial from the University of Wisconsin–Madison is evaluating transplantation of bone marrow cells into the salivary glands to …
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: Longitudinal Oral Health Changes After Head and Neck Radiotherapy
ClinicalTrials.gov update describing an ongoing longitudinal study of oral health changes in patients after radiotherapy for head and neck c…
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CLINICAL_TRIALS research · 2026-02-02Clinical Trial Update: A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia [Phase 2]
Phase 2 clinical trial evaluating AAV2-hAQP1 gene therapy for radiation-induced xerostomia following radiotherapy for upper aerodigestive tr…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Burning Mouth Syndrome: Effects of Occlusal Splint Therapy [NA]
A clinical trial is evaluating occlusal splint therapy for Burning Mouth Syndrome and related orofacial pain, with recruitment not yet start…
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CLINICAL_TRIALS research · 2026-01-05Clinical Trial Update: Photobiomodulation Therapy Plus M-health in Head and Neck Cancer Patients: LAXER Study [NA]
Clinical trial evaluating photobiomodulation therapy with mobile-health support in head and neck cancer patients. The study lists xerostomia…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Hyaluronic Acid in the Treatment of Hyposalivation [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating hyaluronic acid for xerostomia due to hyposecretion of the salivary glands; enrollment is ongoing by inv…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Repeated Mesenchymal Stem Cell Therapy for Radiation-Induced Hyposalivation and Xerostomia in Head and Neck Cancer Survivors [Phase 2]
A Phase 2 clinical trial is evaluating repeated mesenchymal stem cell therapy for radiation-induced hyposalivation and xerostomia in head an…
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CLINICAL_TRIALS trial_result · 2025-10-16Clinical Trial Update: Long-term Follow-up of Gene Therapy for Radiation-Induced Xerostomia [Phase 2]
An update on long-term follow-up for a Phase 2 gene therapy targeting radiation-induced xerostomia in patients treated for upper aerodigesti…
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CLINICAL_TRIALS research · 2025-10-15Clinical Trial Update: Oral Health Intervention in Adult Primary Care [NA]
This recruiting clinical trial at Case Western Reserve University is testing an oral health intervention in adults in primary care, addressi…
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: Screening of Biomarkers and Related Mechanisms for RIX
An ongoing clinical trial at Zhejiang University is screening biomarkers and mechanisms related to radiotherapy-induced xerostomia (RIX).
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Photodynamic Treatment as Part of Oral Healthcare on Persons With Sjögren's Syndrome [NA]
A clinical trial update indicates an ongoing photodynamic treatment study for people with Sjögren's syndrome and xerostomia. The trial statu…
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FDA approval · 2025-07-24FDA Approved: CEVIMELINE HYDROCHLORIDE — Supplemental Application (Rising Pharma Holdings, Inc.)
FDA approved a supplemental application for cevimeline hydrochloride from Rising Pharma Holdings, Inc., confirming changes to the product's …
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CLINICAL_TRIALS trial_result · 2025-07-24Clinical Trial Update: Effects of Chewing Gum for Dry Mouth in Diabetes [NA]
A completed clinical trial investigating the effects of chewing gum on dry mouth symptoms in individuals with diabetes.
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CLINICAL_TRIALS research · 2025-07-20Clinical Trial Update: d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC [Phase 1]
A Phase 1 clinical trial is evaluating the addition of d-Limonene to radiation and platinum-based chemotherapy to prevent xerostomia in pati…
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CLINICAL_TRIALS research · 2025-07-01Clinical Trial Update: Observational Study of Dental Outcomes in Head and Neck Cancer Patients
An observational study to assess dental outcomes in head and neck cancer patients, including xerostomia and osteoradionecrosis; the trial is…
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CLINICAL_TRIALS other · 2025-06-19Clinical Trial Update: Laser Acupoints Stimulation on Xerostomia Related Chemoradiotherapy for Head and Neck Cancer Patients [NA]
A clinical trial assessing laser acupoint stimulation to alleviate xerostomia in head and neck cancer patients undergoing chemoradiotherapy.…
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: Effect of Enzymatic-Containing Mouth Spray (Oral7®) on Xerostomia Symptoms, Salivary Flow Rate, and Oral Health-Related Quality of Life in Older Patients [NA]
A clinical trial evaluating an enzymatic mouth spray (Oral7) for xerostomia in older adults, with the study currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-05-28Clinical Trial Update: Acupressure on Xerostomia in Head and Neck Cancer Patients [NA]
A clinical trial sponsored by The University of Hong Kong is evaluating acupressure to treat xerostomia in head and neck cancer patients. Th…