X-linked Hypophosphatemia
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EMA approval · 2026-04-08EMA Authorised: Crysvita (burosumab) — Kyowa Kirin Holdings B.V.
The EMA authorised Crysvita (burosumab) for X-linked hypophosphatemia and related familial hypophosphatemia and osteomalacia indications, wi…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: X-linked Hypophosphatemia Disease Monitoring Program
Ultragenyx is conducting a disease monitoring program for X-linked hypophosphatemia and related hypophosphatemic rickets, currently active b…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia [Phase 1, Phase 2]
This entry reports a first-in-human clinical trial of KK8123 in adults with X-linked hypophosphatemia, a Phase 1/2 study that is currently r…
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CLINICAL_TRIALS trial_result · 2025-10-01Clinical Trial Update: Calcitriol Monotherapy for X-Linked Hypophosphatemia [EARLY_Phase 1]
The document reports an EARLY_PHASE1 trial of Calcitriol as monotherapy for X-linked hypophosphatemia with status ACTIVE_NOT_RECRUITING.
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: Effective Dosing of Burosumab in XLH
This clinical trial update addresses effective dosing of burosumab for X-linked hypophosphatemia and is currently recruiting at the Universi…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: Study of Longitudinal Observation for Patient With X-linked Hypophosphatemic Rickets/Osteomalacia in Collaboration With Asian Partners
A longitudinal observational study of patients with X-linked hypophosphatemia is being conducted in collaboration with Asian partners. The t…
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CLINICAL_TRIALS research · 2025-08-29Clinical Trial Update: Post Marketing Surveillance Study to Observe Safety and Effectiveness of CRYSVITA® in S. Korean Patients
Post-marketing surveillance study to observe the safety and effectiveness of CRYSVITA (burosumab) in South Korean patients with FGF23-relate…
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FDA label_change · 2025-08-28FDA Approved: CRYSVITA — Supplemental Application (Kyowa Kirin, Inc.)
FDA approved a supplemental application for CRYSVITA (burosumab) submitted by Kyowa Kirin, Inc. to update the product labeling. The document…
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CLINICAL_TRIALS research · 2025-07-20Clinical Trial Update: Burden of Disease and Functional Impairment in XLH
This clinical trial update reports on the burden of disease and functional impairment experienced by people with X-linked hypophosphatemia (…
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CLINICAL_TRIALS other · 2025-05-23Clinical Trial Update: The Impact of Phosphate Metabolism on Healthy Aging [EARLY_Phase 1]
A Yale University–sponsored early-phase clinical trial investigating phosphate metabolism in healthy aging is currently suspended; the trial…
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CLINICAL_TRIALS research · 2025-04-13Clinical Trial Update: Phosphorus-31 Spectroscopy in Phosphate Diabetes [NA]
Clinical trial update notes a NOT_YET_RECRUITING study using phosphorus-31 spectroscopy to investigate phosphate-related conditions, includi…
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CLINICAL_TRIALS other · 2025-03-05Clinical Trial Update: Expanded Access to Burosumab
Expanded access program for burosumab is available for patients with X-linked Hypophosphatemia or Tumor-Induced Osteomalacia.
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CLINICAL_TRIALS trial_result · 2024-11-07Clinical Trial Update: Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of Burosumab in Patients Less Than 1 Year of Age [Phase 1, Phase 2]
This trial evaluated Burosumab in infants under 1 year with X-linked hypophosphatemia to assess safety, tolerability, pharmacokinetics and e…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: Registry for Patients With X-Linked Hypophosphatemia
This update describes a registry-based clinical trial for patients with X-Linked Hypophosphatemia, which is currently recruiting.
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CLINICAL_TRIALS research · 2024-09-04Clinical Trial Update: A Study to Describe the Lived Experience of XLH for Adolescents at End of Skeletal Growth
This clinical trial update describes a completed study that investigates the lived experience of adolescents with X-Linked Hypophosphatemia …
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CLINICAL_TRIALS trial_result · 2024-07-09Clinical Trial Update: Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Pediatric Chinese Patients With XLH [Phase 4]
A Phase 4 study evaluating the safety, pharmacokinetics, and efficacy of KRN23 in pediatric Chinese patients with X-linked hypophosphatemia …
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CLINICAL_TRIALS trial_result · 2024-07-09Clinical Trial Update: Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Adult Chinese Patients With XLH [Phase 4]
A Phase 4 trial evaluated the safety, pharmacokinetics, and efficacy of KRN23 (burosumab) in adult Chinese patients with X-linked hypophosph…
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CLINICAL_TRIALS trial_result · 2024-06-17Clinical Trial Update: A Study of KRN23 in X-linked Hypophosphatemia [Phase 1]
An update on Kyowa Kirin's Phase 1 study of KRN23 for X-linked Hypophosphatemia, noting that the trial has completed.
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CLINICAL_TRIALS trial_result · 2023-08-24Clinical Trial Update: Examining the Effect of Burosumab on Muscle Function [Phase 4]
Phase 4 clinical trial assessing the effect of burosumab on muscle function in X-linked hypophosphatemia has completed with results posted.
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CLINICAL_TRIALS trial_result · 2023-05-03Clinical Trial Update: Anti-FGF23 (Burosumab) in Adult Patients With XLH [Phase 3]
Phase 3 trial update for burosumab in adults with X-linked Hypophosphatemia (XLH) has been completed.
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CLINICAL_TRIALS trial_result · 2022-05-20Clinical Trial Update: Study of the Anti-FGF23 Antibody, Burosumab, in Adults With XLH [Phase 3]
Phase 3 trial update for burosumab in adults with X-linked hypophosphatemia has completed.
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CLINICAL_TRIALS trial_result · 2021-05-05Clinical Trial Update: Prevention of Spontaneous Dental Abscesses in Children With X-linked Hypophosphatemia : a RCT [Phase 3]
Phase 3 randomized trial assessing prevention of spontaneous dental abscesses in children with X-linked hypophosphatemia (XLH).
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CLINICAL_TRIALS trial_result · 2021-02-17Clinical Trial Update: An Extension Study of KRN23 in Adults With X-Linked Hypophosphatemia [Phase 1, Phase 2]
An extension study of KRN23 (burosumab) in adults with X-linked hypophosphatemia has completed Phase 1/Phase 2, with results posted in Febru…
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CLINICAL_TRIALS trial_result · 2021-02-05Clinical Trial Update: Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH) [Phase 3]
Phase 3 study of KRN23 (burosumab) in adults with X-linked hypophosphatemia has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2020-10-26Clinical Trial Update: A Repeated Study of KRN23 in Adults With X-Linked Hypophosphatemia [Phase 1, Phase 2]
A Phase 1/Phase 2 study of KRN23 in adults with X-linked hypophosphatemia has completed, and results were posted in 2020.